Innovative Therapy for Classic Galactosemia - Tale of Two HTS
Gal-1P (an intermediate) and galactitol (a by-product) of the blocked galactose metabolic pathway interfere inositol turnover and inositol entry by inhibiting IMPase and SMIT, respectively. This could potentially decrease cellular PIP2 content and adversely affect normal AKT function. Blockage of galactose metabolism has also been shown to up-regulate ARHI gene expression [], which negatively regulate AKT activity in the cells. (Abbreviations: PIP2: phosphatidylinositol-4,5-biphosphate; IP3: inositol-1,4,5-triphosphate; IP2: inositol bisphosphate; IP1: inositol monophosphate; PIP3: phosphatidylinositol-3,4,5-triphosphate; SMIT1: Na+/myo-inositol transporter; IMPase: inositol monophosphatase; P13K: phosphatidylinositol 3-kinase; GPCR: G-protein coupled receptor. L: ligand for GPCR; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; PTEN: phosphatase and tensin homolog; ARHI: aplysia ras homolog I.)
Publication
Innovative Therapy for Classic Galactosemia - Tale of Two HTS. () M Tang, et al. Mol Genet Metab. ;105(1):44-55. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | EGF) | EGF | ncbigene_symbol | EGF | 1950 |
| Homo sapiens | Primates | EGFR | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | FZD4 | 8322 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | NMUR1 | 10316 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | LPAR3 | 23566 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | LGR6 | 59352 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | MRGPRX3 | 117195 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | MRGPRX4 | 117196 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | GPR151 | 134391 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | OXER1 | 165140 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | GPRC6A | 222545 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | MRGPRX1 | 259249 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | VN1R17P | 441931 |
| Homo sapiens | Primates | GPCR | GPCR | ncbigene_synonym | GPR166P | 442206 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM1 | 2911 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM2 | 2912 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM3 | 2913 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM4 | 2914 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM5 | 2915 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM6 | 2916 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM7 | 2917 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GRM8 | 2918 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | CASR | 846 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GABBR1 | 2550 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GABBR2 | 9568 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPR156 | 165829 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPR158 | 57512 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPR179 | 440435 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPRC5A | 9052 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPRC5B | 51704 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPRC5C | 55890 |
| Homo sapiens | Primates | GPCR | GPCR | famplex_relations | GPRC5D | 55507 |
| Homo sapiens | Primates | PLC | PLC | ncbigene_synonym | HSPG2 | 3339 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCE1 | 51196 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCZ1 | 89869 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCB1 | 23236 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCB2 | 5330 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCB3 | 5331 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCB4 | 5332 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCD1 | 5333 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCD3 | 113026 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCD4 | 84812 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCG1 | 5335 |
| Homo sapiens | Primates | PLC | PLC | famplex_relations | PLCG2 | 5336 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | ARHI- | ARHI | ncbigene_synonym | DIRAS3 | 9077 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | IP2 | IP2 | ncbigene_synonym | IKBKG | 8517 |
| Homo sapiens | Primates | GALK | GALK | ncbigene_synonym | GALK1 | 2584 |
| Homo sapiens | Primates | Gal-1-p | GAL1 | ncbigene_synonym | LGALS1 | 3956 |
| Homo sapiens | Primates | GALT | GALT | ncbigene_symbol | GALT | 2592 |
| Homo sapiens | Primates | GALT | GALT | ncbigene_synonym | B3GLCT | 145173 |
| Drosophila melanogaster | Invertebrates | EGF) | EGF | ncbigene_synonym | Egfr | 37455 |
| Drosophila melanogaster | Invertebrates | GPCR | GPCR | ncbigene_synonym | Oamb | 43982 |
| Drosophila melanogaster | Invertebrates | PLC | PLC | ncbigene_synonym | norpA | 31376 |
| Drosophila melanogaster | Invertebrates | PLC | PLC | ncbigene_synonym | sl | 32601 |
| Drosophila melanogaster | Invertebrates | PLC | PLC | ncbigene_synonym | Plc21C | 33204 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K21B | 33203 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K59F | 37733 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K68D | 39329 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K92E | 42446 |
| Drosophila melanogaster | Invertebrates | AKT | AKT | ncbigene_symbol | Akt | 41957 |
| Drosophila melanogaster | Invertebrates | PTEN | PTEN | ncbigene_symbol | Pten | 43991 |
| Drosophila melanogaster | Invertebrates | GALK | GALK | ncbigene_symbol | Galk | 39031 |
| Drosophila melanogaster | Invertebrates | GALT | GALT | ncbigene_symbol | Galt | 33935 |
| Drosophila melanogaster | Invertebrates | GALT | GALT | ncbigene_synonym | beta4GalT7 | 42991 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Galactitol | Galactitol | mesh:D004376 | galactitol | chebi:16813 |
| Galactose | Galactose | mesh:D005690 | galactose | chebi:28260 |
| Glucose | Glucose | mesh:D005947 | D-glucopyranose | chebi:4167 |
| phosphate | NA | mesh:D010710 | ||
| UDP-Cialactose | Uridine Diphosphate | mesh:D014530 | UDP | chebi:17659 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |