Acute and Chronic Regulation of Aldosterone Production

The adrenal cortex produces zone-specific steroids as a result of differential expression of steroidogenic enzymes. In the initial step of steroidogenesis, steroidogenic acute regulatory (StAR) protein is needed for the rate-limiting step of movement of cholesterol to the inner mitochondrial membrane, where cholesterol is cleaved by cholesterol side-chain cleavage (CYP11A1) to pregnenolone. Further steps of the steroidogenic pathway include the enzymes 3β-hydroxysteroid dehydrogenase type 2 (HSD3B2), 17α-hydroxylase, 17,20-lyase (CYP17), 21-hydrolylase (CYP21), 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2).
Acute and Chronic Regulation of Aldosterone Production
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Publication

Acute and Chronic Regulation of Aldosterone Production. () Namita Hattangady, et al. Mol Cell Endocrinol. ;350(2):151-162. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents OH OH ncbigene_symbol oh 18299
Mus musculus Rodents CYP11A1 CYP11A1 ncbigene_symbol Cyp11a1 13070
Mus musculus Rodents STAR STAR ncbigene_symbol Star 20845
Mus musculus Rodents CYP11B2 CYP11B2 ncbigene_symbol Cyp11b2 13072
Mus musculus Rodents CYP21 CYP21 ncbigene_synonym Cyp21a1 13079
Mus musculus Rodents HSD3B2 HSD3B2 ncbigene_symbol Hsd3b2 15493
Mus musculus Rodents CYP17 CYP17 ncbigene_synonym Cyp17a1 13074
Mus musculus Rodents CYP11B1 CYP11B1 ncbigene_symbol Cyp11b1 110115
Homo sapiens Primates CYP11A1 CYP11A1 ncbigene_symbol CYP11A1 1583
Homo sapiens Primates STAR STAR ncbigene_symbol STAR 6770
Homo sapiens Primates STAR STAR ncbigene_synonym GUCY2C 2984
Homo sapiens Primates STAR STAR ncbigene_synonym CD163L1 283316
Homo sapiens Primates CYP11B2 CYP11B2 ncbigene_symbol CYP11B2 1585
Homo sapiens Primates CYP21 CYP21 ncbigene_synonym CYP21A2 1589
Homo sapiens Primates HSD3B2 HSD3B2 ncbigene_symbol HSD3B2 3284
Homo sapiens Primates CYP17 CYP17 ncbigene_synonym CYP17A1 1586
Homo sapiens Primates CYP11B1 CYP11B1 ncbigene_symbol CYP11B1 1584
Rattus norvegicus Rodents CYP11A1 CYP11A1 ncbigene_symbol Cyp11a1 29680
Rattus norvegicus Rodents STAR STAR ncbigene_symbol Star 25557
Rattus norvegicus Rodents CYP11B2 CYP11B2 ncbigene_symbol Cyp11b2 24294
Rattus norvegicus Rodents CYP21 CYP21 ncbigene_synonym Cyp21a1 24298
Rattus norvegicus Rodents HSD3B2 HSD3B2 ncbigene_symbol Hsd3b2 29632
Rattus norvegicus Rodents CYP17 CYP17 ncbigene_synonym Cyp17a1 25146
Rattus norvegicus Rodents CYP11B1 CYP11B1 ncbigene_symbol Cyp11b1 500892
Bos taurus Mammals CYP11A1 CYP11A1 ncbigene_symbol CYP11A1 338048
Bos taurus Mammals STAR STAR ncbigene_symbol STAR 281507
Bos taurus Mammals CYP11B2 CYP11B2 ncbigene_symbol CYP11B2 282423
Bos taurus Mammals CYP21 CYP21 ncbigene_synonym CYP21A2 281741
Bos taurus Mammals CYP17 CYP17 ncbigene_synonym CYP17A1 281739
Bos taurus Mammals CYP11B1 CYP11B1 ncbigene_symbol CYP11B1 282422

Chemical mentions

Word Match MeSH Name ChEBI
Aldosterone Aldosterone mesh:D000450 aldosterone chebi:27584
Cholesterol Cholesterol mesh:D002784 cholesterol chebi:16113
Corticosterone Corticosterone mesh:D003345 corticosterone chebi:16827
Deoxycorticosterone Desoxycorticosterone mesh:D003900 11-deoxycorticosterone chebi:16973
Cortisol Hydrocortisone mesh:D006854 cortisol chebi:17650
Hydroxypregnenolone 17-alpha-Hydroxypregnenolone mesh:D006907 17alpha-hydroxypregnenolone chebi:28750
Hydroxyprogesterone NA mesh:D006908
Pregnenolone Pregnenolone mesh:D011284 pregnenolone chebi:16581
Progesterone Progesterone mesh:D011374 progesterone chebi:17026
Steroid Steroids mesh:D013256 steroid chebi:35341
18-Hydroxycorticosterone 18-Hydroxycorticosterone mesh:D015069 18-hydroxycorticosterone chebi:16485

Disease mentions

Word Match MeSH Name DOID