Novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy

The right side is for the signal cascade in the cell cycle G1/S checkpoint signaling pathway while the left side is for the P53 signaling pathway. The drug-dose pairs are listed in the middle. The drug-targeted pathway was generated using IPA software (Ingenuity Systems, Inc. Redwood City, CA).
Novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

A novel method of transcriptional response analysis to facilitate drug repositioning for cancer therapy. () Guangxu Jin, et al. Cancer Res. ;72(1):33-44. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates p16 P16 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates p16 P16 ncbigene_synonym H3P10 115482713
Homo sapiens Primates p15 P15 ncbigene_synonym CDKN2B 1030
Homo sapiens Primates p15 P15 ncbigene_synonym MRPL28 10573
Homo sapiens Primates p15 P15 ncbigene_synonym SUB1 10923
Homo sapiens Primates p15 P15 ncbigene_synonym NXT1 29107
Homo sapiens Primates p15 P15 ncbigene_synonym H3P9 115482684
Homo sapiens Primates CDK CDK famplex_relations CDKL1 8814
Homo sapiens Primates CDK CDK famplex_relations CDKL2 8999
Homo sapiens Primates CDK CDK famplex_relations CDKL3 51265
Homo sapiens Primates CDK CDK famplex_relations CDKL4 344387
Homo sapiens Primates CDK CDK famplex_relations CDKL5 6792
Homo sapiens Primates CDK CDK famplex_relations CDK3 1018
Homo sapiens Primates CDK CDK famplex_relations CDK4 1019
Homo sapiens Primates CDK CDK famplex_relations CDK5 1020
Homo sapiens Primates CDK CDK famplex_relations CDK6 1021
Homo sapiens Primates CDK CDK famplex_relations CDK7 1022
Homo sapiens Primates CDK CDK famplex_relations CDK8 1024
Homo sapiens Primates CDK CDK famplex_relations CDK9 1025
Homo sapiens Primates CDK CDK famplex_relations CDK10 8558
Homo sapiens Primates CDK CDK famplex_relations CDK11A 728642
Homo sapiens Primates CDK CDK famplex_relations CDK11B 984
Homo sapiens Primates CDK CDK famplex_relations CDK12 51755
Homo sapiens Primates CDK CDK famplex_relations CDK13 8621
Homo sapiens Primates CDK CDK famplex_relations CDK14 5218
Homo sapiens Primates CDK CDK famplex_relations CDK15 65061
Homo sapiens Primates CDK CDK famplex_relations CDK16 5127
Homo sapiens Primates CDK CDK famplex_relations CDK17 5128
Homo sapiens Primates CDK CDK famplex_relations CDK18 5129
Homo sapiens Primates CDK CDK famplex_relations CDK19 23097
Homo sapiens Primates CDK CDK famplex_relations CDK20 23552
Homo sapiens Primates CDK CDK famplex_relations CDK1 983
Homo sapiens Primates CDK CDK famplex_relations CDK2 1017
Homo sapiens Primates SCF SCF ncbigene_synonym KITLG 4254
Homo sapiens Primates MDM2 MDM2 ncbigene_symbol MDM2 4193
Homo sapiens Primates EBP1 EBP1 ncbigene_synonym NFKB1 4790
Homo sapiens Primates EBP1 EBP1 ncbigene_synonym PA2G4 5036
Homo sapiens Primates Abl1 ABL1 ncbigene_symbol ABL1 25
Homo sapiens Primates Abl1 ABI1 ncbigene_symbol ABI1 10006
Homo sapiens Primates TP53 TP53 ncbigene_symbol TP53 7157
Homo sapiens Primates SIN3A SIN3A ncbigene_symbol SIN3A 25942
Homo sapiens Primates Suv39H1 SUV39H1 ncbigene_symbol SUV39H1 6839
Homo sapiens Primates E2F E2F famplex_relations E2F1 1869
Homo sapiens Primates E2F E2F famplex_relations E2F2 1870
Homo sapiens Primates E2F E2F famplex_relations E2F3 1871
Homo sapiens Primates E2F E2F famplex_relations E2F4 1874
Homo sapiens Primates E2F E2F famplex_relations E2F5 1875
Homo sapiens Primates E2F E2F famplex_relations E2F6 1876
Homo sapiens Primates E2F E2F famplex_relations E2F7 144455
Homo sapiens Primates E2F E2F famplex_relations E2F8 79733
Homo sapiens Primates HDAC HDAC ncbigene_synonym HDAC9 9734
Homo sapiens Primates HDAC HDAC famplex_relations HDAC1 3065
Homo sapiens Primates HDAC HDAC famplex_relations HDAC2 3066
Homo sapiens Primates HDAC HDAC famplex_relations HDAC3 8841
Homo sapiens Primates HDAC HDAC famplex_relations HDAC8 55869
Homo sapiens Primates HDAC HDAC famplex_relations HDAC4 9759
Homo sapiens Primates HDAC HDAC famplex_relations HDAC5 10014
Homo sapiens Primates HDAC HDAC famplex_relations HDAC7 51564
Homo sapiens Primates HDAC HDAC famplex_relations HDAC6 10013
Homo sapiens Primates HDAC HDAC famplex_relations HDAC10 83933
Homo sapiens Primates HDAC HDAC famplex_relations SIRT1 23411
Homo sapiens Primates HDAC HDAC famplex_relations SIRT2 22933
Homo sapiens Primates HDAC HDAC famplex_relations SIRT3 23410
Homo sapiens Primates HDAC HDAC famplex_relations SIRT4 23409
Homo sapiens Primates HDAC HDAC famplex_relations SIRT5 23408
Homo sapiens Primates HDAC HDAC famplex_relations SIRT6 51548
Homo sapiens Primates HDAC HDAC famplex_relations SIRT7 51547
Homo sapiens Primates HDAC HDAC famplex_relations HDAC11 79885
Homo sapiens Primates DP-1 DP-1 ncbigene_synonym TFDP1 7027
Homo sapiens Primates CyclinE/A CYCLINE famplex_relations CCNE1 898
Homo sapiens Primates CyclinE/A CYCLINE famplex_relations CCNE2 9134
Homo sapiens Primates CyclinE/A CYCLINA famplex_relations CCNA1 8900
Homo sapiens Primates CyclinE/A CYCLINA famplex_relations CCNA2 890
Homo sapiens Primates Cdc2 CDC2 ncbigene_synonym POLD1 5424
Homo sapiens Primates c-Myc C-MYC ncbigene_synonym MYC 4609
Homo sapiens Primates p107 P107 ncbigene_synonym RBL1 5933
Homo sapiens Primates RanGap RANGAP ncbigene_synonym RANGAP1 5905
Homo sapiens Primates TK TK famplex_relations TK1 7083
Homo sapiens Primates TK TK famplex_relations TK2 7084
Homo sapiens Primates DHFR DHFR ncbigene_symbol DHFR 1719
Homo sapiens Primates PCNA PCNA ncbigene_symbol PCNA 5111
Homo sapiens Primates H2A H2A ncbigene_synonym TUBA4A 7277
Homo sapiens Primates H2A H2A ncbigene_synonym H2AC18 8337
Homo sapiens Primates H2A H2A ncbigene_synonym H2AC20 8338
Homo sapiens Primates H2A H2A ncbigene_synonym TUBA3D 113457
Drosophila melanogaster Invertebrates p16 P16 ncbigene_synonym Zdhhc8 31887
Drosophila melanogaster Invertebrates p16 P16 ncbigene_synonym Arpc5 33444
Drosophila melanogaster Invertebrates p16 P16 ncbigene_synonym Su(osk)P16 250692
Drosophila melanogaster Invertebrates p15 P15 ncbigene_synonym dap 36001
Drosophila melanogaster Invertebrates p15 P15 ncbigene_synonym Nxt1 37769
Drosophila melanogaster Invertebrates CDK CDK ncbigene_synonym Cdk4 36854
Drosophila melanogaster Invertebrates SCF SCF ncbigene_symbol scf 38145
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates CDK2 CDK2 ncbigene_symbol Cdk2 42453
Drosophila melanogaster Invertebrates Rb-dependent RB ncbigene_symbol rb 31381
Drosophila melanogaster Invertebrates Abl1 ABL1 ncbigene_synonym Abl 45821
Drosophila melanogaster Invertebrates Abl1 ABI1 ncbigene_synonym Abi 41718
Drosophila melanogaster Invertebrates SIN3A SIN3A ncbigene_symbol Sin3A 36382
Drosophila melanogaster Invertebrates Suv39H1 SUV39H1 ncbigene_synonym Su(var)3-9 41483
Drosophila melanogaster Invertebrates E2F E2F ncbigene_synonym ebi 33212
Drosophila melanogaster Invertebrates E2F E2F ncbigene_synonym E2f2 35381
Drosophila melanogaster Invertebrates E2F E2F ncbigene_synonym E2f1 42550
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC4 32278
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC6 32461
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC1 38565
Drosophila melanogaster Invertebrates HDAC HDAC ncbigene_synonym HDAC3 44446
Drosophila melanogaster Invertebrates DP-1 DP1 ncbigene_symbol Dp1 37116
Drosophila melanogaster Invertebrates DP-1 DP1 ncbigene_synonym Dp 36461
Drosophila melanogaster Invertebrates DP-1 DP1 ncbigene_synonym Aplip1 53472
Drosophila melanogaster Invertebrates CyclinE/A CYCLINE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates CyclinE/A CYCLINA ncbigene_synonym CycA 39340
Drosophila melanogaster Invertebrates E2F/1/2/3 E3 ncbigene_symbol E3 5658048
Drosophila melanogaster Invertebrates Cdc2 CDC2 ncbigene_synonym Cdk1 34411
Drosophila melanogaster Invertebrates Cdc2 CDC2 ncbigene_synonym fzy 34968
Drosophila melanogaster Invertebrates c-Myc C-MYC ncbigene_synonym Myc 31310
Drosophila melanogaster Invertebrates RanGap RANGAP ncbigene_symbol RanGAP 35223
Drosophila melanogaster Invertebrates TK TK ncbigene_symbol Tk 41456
Drosophila melanogaster Invertebrates DHFR DHFR ncbigene_symbol Dhfr 42003
Drosophila melanogaster Invertebrates PCNA PCNA ncbigene_symbol PCNA 37290
Drosophila melanogaster Invertebrates H2A H2A ncbigene_synonym His2Av 43229

Chemical mentions

Word Match MeSH Name ChEBI
tamoxifen Tamoxifen mesh:D013629 tamoxifen chebi:41774
paclitaxel Paclitaxel mesh:D017239 paclitaxel chebi:45863
raloxifene Raloxifene Hydrochloride mesh:D020849 raloxifene hydrochloride chebi:50740

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Melanoma NA