TOR in the immune system

mTOR regulates many cellular activities through two distinct complexes; mTORC1 and mTORC2. mTORC1 is inhibited by the rapamycin-FKBP12 complex. mTORC2 is usually insensitive to rapamycin, but prolonged treatment decreases the mTORC2 activity in some cells. The ribosome is recently found to regulate activation of mTORC2 []. Arrows and bars represent activation and inhibition, respectively.
TOR in the immune system
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Publication

TOR in the immune system. () Koichi Araki, et al. Curr Opin Cell Biol. ;23(6):707-715. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA1 5562
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAA2 5563
Homo sapiens Primates AMPK AMPK ncbigene_synonym PRKAB1 5564
Homo sapiens Primates AMPK AMPK famplex_relations PRKAB2 5565
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG1 5571
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG2 51422
Homo sapiens Primates AMPK AMPK famplex_relations PRKAG3 53632
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates (TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates (TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1A 2280
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP1 2282
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP2 2283
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP3 2284
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP4 2285
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates Rictor RICTOR ncbigene_symbol RICTOR 253260
Homo sapiens Primates Protor-1 PROTOR-1 ncbigene_synonym PRR5 55615
Homo sapiens Primates Deptor DEPTOR ncbigene_symbol DEPTOR 64798
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates MLST8 MLST8 ncbigene_symbol MLST8 64223
Homo sapiens Primates PRAS40 PRAS40 ncbigene_synonym AKT1S1 84335
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates SGK SGK ncbigene_synonym SGK1 6446
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates Actin ACTIN famplex_relations ACTA1 58
Homo sapiens Primates Actin ACTIN famplex_relations ACTA2 59
Homo sapiens Primates Actin ACTIN famplex_relations ACTB 60
Homo sapiens Primates Actin ACTIN famplex_relations ACTC1 70
Homo sapiens Primates Actin ACTIN famplex_relations ACTG1 71
Homo sapiens Primates Actin ACTIN famplex_relations ACTG2 72
Homo sapiens Primates EIF4E EIF4E ncbigene_symbol EIF4E 1977
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E2 9470
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E3 317649
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents (TSC1 TSC1 ncbigene_symbol Tsc1 64930
Mus musculus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents FKBP12 FKBP12 ncbigene_synonym Fkbp1a 14225
Mus musculus Rodents Rheb RHEB ncbigene_symbol Rheb 19744
Mus musculus Rodents Rictor RICTOR ncbigene_symbol Rictor 78757
Mus musculus Rodents Protor-1 PROTOR-1 ncbigene_synonym Prr5 109270
Mus musculus Rodents Raptor RAPTOR ncbigene_synonym Rptor 74370
Mus musculus Rodents Deptor DEPTOR ncbigene_symbol Deptor 97998
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents MLST8 MLST8 ncbigene_symbol Mlst8 56716
Mus musculus Rodents PRAS40 PRAS40 ncbigene_synonym Akt1s1 67605
Mus musculus Rodents SGK SGK ncbigene_synonym Sgk1 20393
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Mus musculus Rodents EIF4E EIF4E ncbigene_symbol Eif4e 13684
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym SNF4Agamma 42515
Drosophila melanogaster Invertebrates AMPK AMPK ncbigene_synonym AMPKalpha 43904
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates (TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates FKBP12 FKBP12 ncbigene_symbol Fkbp12 37214
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates Rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates PRAS40 PRAS40 ncbigene_symbol PRAS40 26067067
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates SGK SGK ncbigene_synonym Tpi 43582
Drosophila melanogaster Invertebrates 4E-BP 4E-BP ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act5C 31521
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act42A 35526
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act57B 37368
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act79B 40444
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act88F 41885
Drosophila melanogaster Invertebrates Actin ACTIN ncbigene_synonym Act87E 48632
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E7 31059
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E4 38743
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E5 38878
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E3 38923
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E6 43422
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E1 45525
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4EHP 326255

Chemical mentions

Word Match MeSH Name ChEBI
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID
Cancer NA