Clopidogrel activation and platelet aggregation pathways

Clopidogrel activation and platelet aggregation pathways. (a) Activation pathway for clopidogrel in liver. (b) Mechanism of clopidogrel’s antiplatelet action. Figure copyright PharmGKB; reprinted with permission of PharmGKB and Stanford University.
Clopidogrel activation and platelet aggregation pathways
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Publication

Pharmacogenetics and Clopidogrel Response in Patients Undergoing Percutaneous Coronary Interventions. () AL Beitelshees, et al. Clin Pharmacol Ther. ;89(3):455-459. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates P450 P450 ncbigene_synonym CYP2B6 1555
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A1 1291
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A2 1292
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A3 1293
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A5 256076
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL6A6 131873
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL7A1 1294
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL8A1 1295
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL8A2 1296
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A1 1297
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A2 1298
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL9A3 1299
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL10A1 1300
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL11A1 1301
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL11A2 1302
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL12A1 1303
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL13A1 1305
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL14A1 7373
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL15A1 1306
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL16A1 1307
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL17A1 1308
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL18A1 80781
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL19A1 1310
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL20A1 57642
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL21A1 81578
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL22A1 169044
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL23A1 91522
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL24A1 255631
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL25A1 84570
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL26A1 136227
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL27A1 85301
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL28A1 340267
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL1A1 1277
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL1A2 1278
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A1 1282
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A2 1284
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A3 1285
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A4 1286
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A5 1287
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL4A6 1288
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A1 1289
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A2 1290
Homo sapiens Primates Collagen COLLAGEN famplex_relations COL5A3 50509
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates ADP ADP ncbigene_synonym WDTC1 23038
Homo sapiens Primates VWF VWF ncbigene_symbol VWF 7450
Homo sapiens Primates F2 F2 ncbigene_symbol F2 2147
Homo sapiens Primates CYP1A2 CYP1A2 ncbigene_symbol CYP1A2 1544
Homo sapiens Primates P2RY P2RY famplex_relations P2RY1 5028
Homo sapiens Primates P2RY P2RY famplex_relations P2RY2 5029
Homo sapiens Primates P2RY P2RY famplex_relations P2RY4 5030
Homo sapiens Primates P2RY P2RY famplex_relations P2RY6 5031
Homo sapiens Primates P2RY P2RY famplex_relations P2RY8 286530
Homo sapiens Primates P2RY P2RY famplex_relations P2RY10 27334
Homo sapiens Primates P2RY P2RY famplex_relations P2RY11 5032
Homo sapiens Primates P2RY P2RY famplex_relations P2RY12 64805
Homo sapiens Primates P2RY P2RY famplex_relations P2RY13 53829
Homo sapiens Primates P2RY P2RY famplex_relations P2RY14 9934
Homo sapiens Primates P2RY P2RY famplex_relations LPAR4 2846
Homo sapiens Primates P2RY P2RY famplex_relations LPAR6 10161
Homo sapiens Primates F2R F2R ncbigene_symbol F2R 2149
Homo sapiens Primates CYP3A4 CYP3A4 ncbigene_symbol CYP3A4 1576
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAO1 2775
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAI1 2770
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAI2 2771
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAI3 2773
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAT1 2779
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAT2 2780
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAT3 346562
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAZ 2781
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAS 2778
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAL 2774
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNAQ 2776
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNA11 2767
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNA14 9630
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNA15 2769
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNA12 2768
Homo sapiens Primates G-proteins GPROTEIN famplex_relations GNA13 10672
Homo sapiens Primates СYP2CЯ CYP2C ncbigene_synonym CYP2C19 1557
Homo sapiens Primates СYP2CЯ CYP2C ncbigene_synonym CYP2C9 1559
Homo sapiens Primates СYP2CЯ CYP2C ncbigene_synonym CYP2C18 1562
Homo sapiens Primates ADCY3 ADCY3 ncbigene_symbol ADCY3 109
Homo sapiens Primates ADCY3 ADCY3 ncbigene_synonym ADCY8 114
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-8 619465
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-10 100616101
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-9 100616102
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-21 100616103
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-18 100775105
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-25 100862683
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-24 100862684
Homo sapiens Primates Protease PROTEASE ncbigene_synonym ERVK-19 105376906
Homo sapiens Primates PLA2 PLA2 ncbigene_synonym PLA2G1B 5319
Homo sapiens Primates PLA2 PLA2 ncbigene_synonym PLA2G2A 5320
Homo sapiens Primates PLA2 PLA2 ncbigene_synonym PLA2G6 8398
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G3 50487
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G5 5322
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G7 7941
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G10 8399
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G12A 81579
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G12B 84647
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G2C 391013
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G2D 26279
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G2E 30814
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G2F 64600
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G4A 5321
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G4C 8605
Homo sapiens Primates PLA2 PLA2 famplex_relations PLA2G4D 283748
Homo sapiens Primates TBXAS1 TBXAS1 ncbigene_symbol TBXAS1 6916
Homo sapiens Primates Fibrinogen FIBRINOGEN famplex_relations FGA 2243
Homo sapiens Primates Fibrinogen FIBRINOGEN famplex_relations FGB 2244
Homo sapiens Primates Fibrinogen FIBRINOGEN famplex_relations FGG 2266
Homo sapiens Primates PGD2 PGD2 ncbigene_synonym PTGDS 5730
Homo sapiens Primates PGD2 PGD2 ncbigene_synonym HPGDS 27306
Danio rerio Vertebrates VWF VWF ncbigene_symbol vwf 570643
Danio rerio Vertebrates F2 F2 ncbigene_symbol f2 325881
Danio rerio Vertebrates F2R F2R ncbigene_symbol f2r 558477
Danio rerio Vertebrates ADCY3 ADCY3 ncbigene_synonym adcy3b 564719
Danio rerio Vertebrates ADCY3 ADCY3 ncbigene_synonym adcy3a 571825
Danio rerio Vertebrates receptors RECEPTOR ncbigene_synonym kita 30256
Danio rerio Vertebrates receptors RECEPTOR ncbigene_synonym ngfra 100535003
Danio rerio Vertebrates GNAS GNAS ncbigene_symbol gnas 557353
Danio rerio Vertebrates P2RY12 P2RY12 ncbigene_symbol p2ry12 100149618
Danio rerio Vertebrates TBXAS1 TBXAS1 ncbigene_symbol tbxas1 792041
Danio rerio Vertebrates PGI2 PGI2 ncbigene_synonym gpib 246095

Chemical mentions

Word Match MeSH Name ChEBI
Thienopyridine thienopyridine mesh:C446540 thienopyridine chebi:37942
2-Oxo-clopidogrel NA mesh:C540904
Aspirin Aspirin mesh:D001241 acetylsalicylic acid chebi:15365
Prostaglandin prostaglandin mesh:D011453 Prostaglandins chebi:26333

Disease mentions

Word Match MeSH Name DOID