Deciphering the role of Nuclear FactorKB in cellular senescence

DNA damage recruits and activates PARP-1 and ATM, with PARP-1 producing poly(ADP-ribose) leading to assembly of IKKγ/NEMO and PIASy and ATM. PIASy and ATM SUMOylate and phosphorylate IKKγ/NEMO respectively which is then translocated to the cytoplasm to form the IKK complex. ATM independently translocates to the cytoplasm to induce TRAF6-Ubc13 polyubiquitination, which promotes cIAP dependent IKKγ/NEMO ubiquitination which then promotes TAB2-TAK1 dependent phosphorylation and activation of IKKβ.
Deciphering the role of Nuclear FactorKB in cellular senescence
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Publication

Deciphering the role of Nuclear Factor-κB in cellular senescence. (2011) Simon Vaughan, et al. Aging (Albany NY). 2011 Oct;3(10):913-919. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents ATM ATM ncbigene_symbol Atm 11920
Mus musculus Rodents ATM ATM ncbigene_synonym Tpm1 22003
Mus musculus Rodents TAB2 TAB2 ncbigene_symbol Tab2 68652
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Nr2c2 22026
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Map3k7 26409
Mus musculus Rodents PARP-1 PARP-1 ncbigene_synonym Parp1 11545
Mus musculus Rodents PIASY PIASY ncbigene_synonym Pias4 59004
Mus musculus Rodents Ubc13 UBC13 ncbigene_synonym Ube2n 93765
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents CIAP1 CIAP1 ncbigene_synonym Birc3 11796
Mus musculus Rodents CIAP1 CIAP1 ncbigene_synonym Birc2 11797
Mus musculus Rodents IKKB IKKB ncbigene_synonym Ikbkb 16150
Mus musculus Rodents IKKA IKKA ncbigene_synonym Chuk 12675
Mus musculus Rodents NF-KB NF-KB ncbigene_synonym Nfkb1 18033
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates TAB2 TAB2 ncbigene_symbol TAB2 23118
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym MAP3K7 6885
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym NR2C2 7182
Homo sapiens Primates IKKY IKKG ncbigene_synonym IKBKG 8517
Homo sapiens Primates PARP-1 PARP-1 ncbigene_synonym PARP1 142
Homo sapiens Primates PIASY PIASY ncbigene_synonym PIAS4 51588
Homo sapiens Primates Ubc13 UBC13 ncbigene_synonym UBE2N 7334
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates CIAP1 CIAP1 ncbigene_synonym BIRC2 329
Homo sapiens Primates IKKB IKKB ncbigene_synonym IKBKB 3551
Homo sapiens Primates IKKA IKKA ncbigene_synonym CHUK 1147
Homo sapiens Primates NF-KB NF-KB ncbigene_synonym NFKB1 4790
Drosophila melanogaster Invertebrates ATM ATM ncbigene_synonym tefu 41839
Drosophila melanogaster Invertebrates TAB2 TAB2 ncbigene_symbol Tab2 37216
Drosophila melanogaster Invertebrates TAK1 TAK1 ncbigene_symbol Tak1 39659
Drosophila melanogaster Invertebrates IKKY IKKG ncbigene_synonym key 37967
Drosophila melanogaster Invertebrates PARP-1 PARP-1 ncbigene_synonym Parp 3355109
Drosophila melanogaster Invertebrates Ubc13 UBC13 ncbigene_synonym ben 32358
Drosophila melanogaster Invertebrates TRAF6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates IKKB IKKB ncbigene_symbol IKKbeta 44432
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Dif 35045
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates NF-KB NF-KB ncbigene_synonym Rel 41087

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID