Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA

Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA. The mammalian target of rapamycin pathway as a potential target for cancer chemoprevention. Cancer Epidemiol Biomarkers Prev 2007;16:1330–1340.
Pathways involved in mTOR signaling.Abbreviations: mTOR, mammalian target of rapamycin; PI3K, phosphoinositide 3-kinase; TSC, tuberous sclerosis.Adapted from: Kopelovich L, Fay JR, Sigman CC, Crowell JA
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Publication

Utility of mTOR Inhibition in Hematologic Malignancies. (2011) Anas Younes, et al. Oncologist. 2011 Jun;16(6):730-741. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates MTORC2 MTORC2 famplex_relations RICTOR 253260
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521

Chemical mentions

Word Match MeSH Name ChEBI
LY294002 NA mesh:C085911
Perifosine perifosine mesh:C105905 perifosine chebi:67272
Temsirolimus Temsirolimus mesh:C401859 temsirolimus chebi:79699
Ridaforolimus NA mesh:C515074
NVP-BEZ235 dactolisib mesh:C531198 dactolisib chebi:71952
Rapamycin Sirolimus mesh:D020123 sirolimus chebi:9168

Disease mentions

Word Match MeSH Name DOID