EGFR signaling pathway

EGFR signaling pathway. Ligands bind to EGFR and stimulate dimerization of the receptor. RAS is, in turn, activated, stimulating both the PI3K–AKT and RAF–MEK–MAPK pathways, resulting in cell proliferation, survival, and invasion.Abbreviations: EGFR, epidermal growth factor receptor; GRB2, growth factor receptor-bound protein 2; HB-EGF, heparin-binding EGF-like growth factor; MAPK, mitogen-activated protein kinase; MEK, MAPK/extracellular signal–related kinase kinase; PI3K, phosphatidylinositol-3-kinase; SOS, son of sevenless; TGF-α, transforming growth factor α.Reprinted from Raponi M, Winkler H, Dracopoli NC. KRAS mutations predict response to EGFR inhibitors. Curr Opin Pharmacol 2008;8:413–418, copyright 2008, with permission from Elsevier.

Publication

Predicting Response to EGFR Inhibitors in Metastatic Colorectal Cancer: Current Practice and Future Directions. (2010) Veena Shankaran, et al. Oncologist. 2010 Feb;15(2):157-167. Figure: F1. All organisms Homo sapiens Drosophila melanogaster

Disease mentions