Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA

Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA. This schematic representation, created by using Pathway Studio software, shows the connectivity between TGF-β and HEp-2 cell proteins identified as major targets of autoantibodies in SSc patients with unidentified ANA. Protein entities belonging to different functional groups are represented as different shapes. ANA: antinuclear antibody; CALR: calreticulin; CFL1: cofilin 1; FUS: fused in sarcoma; HDAC2: histone deacetylase 2; HNRNPA1: heterogeneous nuclear ribonucleoprotein A1; HNRNPA2B1: heterogeneous nuclear ribonucleoprotein A2/B1; HNRNPL: heterogeneous nuclear ribonucleoprotein L; HSPD1: heat shock 60-kDa protein 1; KHSRP: KH-type splicing regulatory protein (far upstream element-binding protein 2); LMNA: lamin A/C; PCBP2: poly(rC)-binding protein 2; PRDX2: peroxiredoxin 2; RB1: retinoblastoma-associated protein; RBBP4: retinoblastoma-binding protein 4; SOD2: superoxide dismutase 2, mitochondrial; SSc: systemic sclerosis; STMN1: stathmin 1; TGFB1: transforming growth factor β1; TPI1: triosephosphate isomerase 1; VIM: vimentin.
Signalling network of proteins identified as major targets of autoantibodies in patients with unidentified ANA
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Publication

Identification of new autoantibody specificities directed at proteins involved in the transforming growth factor β pathway in patients with systemic sclerosis. (2011) Guillaume Bussone, et al. Arthritis Res Ther. 2011;13(3):R74-R74. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ANA ANA ncbigene_synonym BTG3 10950
Homo sapiens Primates TPI TPI ncbigene_synonym TPI1 7167
Homo sapiens Primates VIM VIM ncbigene_symbol VIM 7431
Homo sapiens Primates LMNA LMNA ncbigene_symbol LMNA 4000
Homo sapiens Primates RBBP4 RBBP4 ncbigene_symbol RBBP4 5928
Homo sapiens Primates RB1 RB1 ncbigene_symbol RB1 5925
Homo sapiens Primates RB1 RB1 ncbigene_synonym RBM45 129831
Homo sapiens Primates DEK DEK ncbigene_symbol DEK 7913
Homo sapiens Primates CALR CALR ncbigene_symbol CALR 811
Homo sapiens Primates FUS FUS ncbigene_symbol FUS 2521
Homo sapiens Primates (HDAC2 HDAC2 ncbigene_symbol HDAC2 3066
Homo sapiens Primates TPIT TPIT ncbigene_synonym TBX19 9095
Homo sapiens Primates PCBP2 PCBP2 ncbigene_symbol PCBP2 5094
Homo sapiens Primates KHSRP KHSRP ncbigene_symbol KHSRP 8570
Homo sapiens Primates HNRNPL HNRNPL ncbigene_symbol HNRNPL 3191
Homo sapiens Primates SOD2 SOD2 ncbigene_symbol SOD2 6648
Homo sapiens Primates SOD2 SOD2 ncbigene_synonym SOD2-OT1 100129518
Homo sapiens Primates PROX2 PROX2 ncbigene_symbol PROX2 283571
Homo sapiens Primates HNRNPA1 HNRNPA1 ncbigene_symbol HNRNPA1 3178
Mus musculus Rodents ANA ANA ncbigene_synonym Btg3 12228
Mus musculus Rodents TPI TPI ncbigene_synonym Tpi1 21991
Mus musculus Rodents VIM VIM ncbigene_symbol Vim 22352
Mus musculus Rodents LMNA LMNA ncbigene_symbol Lmna 16905
Mus musculus Rodents RBBP4 RBBP4 ncbigene_symbol Rbbp4 19646
Mus musculus Rodents RB1 RB1 ncbigene_symbol Rb1 19645
Mus musculus Rodents DEK DEK ncbigene_symbol Dek 110052
Mus musculus Rodents CALR CALR ncbigene_symbol Calr 12317
Mus musculus Rodents FUS FUS ncbigene_symbol Fus 233908
Mus musculus Rodents (HDAC2 HDAC2 ncbigene_symbol Hdac2 15182
Mus musculus Rodents TPIT TPIT ncbigene_synonym Tbx19 83993
Mus musculus Rodents PCBP2 PCBP2 ncbigene_symbol Pcbp2 18521
Mus musculus Rodents KHSRP KHSRP ncbigene_symbol Khsrp 16549
Mus musculus Rodents HNRNPL HNRNPL ncbigene_symbol Hnrnpl 15388
Mus musculus Rodents SOD2 SOD2 ncbigene_symbol Sod2 20656
Mus musculus Rodents PROX2 PROX2 ncbigene_symbol Prox2 73422
Mus musculus Rodents HNRNPA1 HNRNPA1 ncbigene_symbol Hnrnpa1 15382
Rattus norvegicus Rodents TPI TPI ncbigene_synonym Tpi1 24849
Rattus norvegicus Rodents VIM VIM ncbigene_symbol Vim 81818
Rattus norvegicus Rodents LMNA LMNA ncbigene_symbol Lmna 60374
Rattus norvegicus Rodents RBBP4 RBBP4 ncbigene_symbol Rbbp4 313048
Rattus norvegicus Rodents RB1 RB1 ncbigene_symbol Rb1 24708
Rattus norvegicus Rodents DEK DEK ncbigene_symbol Dek 306817
Rattus norvegicus Rodents CALR CALR ncbigene_symbol Calr 64202
Rattus norvegicus Rodents FUS FUS ncbigene_symbol Fus 317385
Rattus norvegicus Rodents (HDAC2 HDAC2 ncbigene_symbol Hdac2 84577
Rattus norvegicus Rodents PCBP2 PCBP2 ncbigene_symbol Pcbp2 363005
Rattus norvegicus Rodents KHSRP KHSRP ncbigene_symbol Khsrp 171137
Rattus norvegicus Rodents HNRNPL HNRNPL ncbigene_symbol Hnrnpl 80846
Rattus norvegicus Rodents HNRNPL HNRNPL ncbigene_synonym Fblim1 362650
Rattus norvegicus Rodents SOD2 SOD2 ncbigene_symbol Sod2 24787
Rattus norvegicus Rodents PROX2 PROX2 ncbigene_symbol Prox2 314319
Rattus norvegicus Rodents HNRNPA1 HNRNPA1 ncbigene_symbol Hnrnpa1 29578
Danio rerio Vertebrates VIM VIM ncbigene_symbol vim 140599
Danio rerio Vertebrates LMNA LMNA ncbigene_symbol lmna 195815
Danio rerio Vertebrates RBBP4 RBBP4 ncbigene_symbol rbbp4 321726
Danio rerio Vertebrates RB1 RB1 ncbigene_symbol rb1 777733
Danio rerio Vertebrates DEK DEK ncbigene_symbol dek 692304
Danio rerio Vertebrates CALR CALR ncbigene_symbol calr 325317
Danio rerio Vertebrates CALR CALR ncbigene_synonym calr3a 30248
Danio rerio Vertebrates FUS FUS ncbigene_symbol fus 394058
Danio rerio Vertebrates PCBP2 PCBP2 ncbigene_symbol pcbp2 321844
Danio rerio Vertebrates KHSRP KHSRP ncbigene_symbol khsrp 573145
Danio rerio Vertebrates HNRNPL HNRNPL ncbigene_symbol hnrnpl 394074
Danio rerio Vertebrates HNRNPL HNRNPL ncbigene_synonym hnrnpl2 573096
Danio rerio Vertebrates SOD2 SOD2 ncbigene_symbol sod2 335799
Danio rerio Vertebrates PROX2 PROX2 ncbigene_symbol prox2 100003863
Danio rerio Vertebrates HNRNPA1 HNRNPA1 ncbigene_synonym hnrnpa1b 378453

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID