Folate metabolic pathway
Folate metabolic pathway. CBS, cystathionine b synthase; DHF, dihydrofolate; DHFR, dihydrofolate reductase; MS, methionine synthase; MT, methyltransferase; MTHFR, methylenetetrahydrofolate reductase; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; SHMT, serine hydroxyl-methyltransferase; THF, tetrahydrofolate. Adapted with permission from Bodnar LM et al.
Publication
Folic Acid Supplementation and Pregnancy: More Than Just Neural Tube Defect Prevention. (2011) James A Greenberg, et al. Rev Obstet Gynecol. 2011 Summer;4(2):52-59. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | CBS | CBS | ncbigene_symbol | Cbs | 33081 |
| Drosophila melanogaster | Invertebrates | CBS | CBS | ncbigene_symbol | cbs | 36492 |
| Drosophila melanogaster | Invertebrates | CBS | CBS | ncbigene_synonym | caboose | 10216631 |
| Drosophila melanogaster | Invertebrates | B6 | B6 | ncbigene_symbol | b6 | 31124 |
| Drosophila melanogaster | Invertebrates | B6 | B6 | ncbigene_synonym | Prosbeta6 | 39855 |
| Drosophila melanogaster | Invertebrates | SHMT | SHMT | ncbigene_symbol | Shmt | 31524 |
| Drosophila melanogaster | Invertebrates | SAH | SAH | ncbigene_symbol | sah | 5658327 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | CkIIbeta | 32132 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Andorra | 32798 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Anp | 43595 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Acam | 44913 |
| Drosophila melanogaster | Invertebrates | MS | MS | ncbigene_symbol | Ms | 44324 |
| Drosophila melanogaster | Invertebrates | DHFR | DHFR | ncbigene_symbol | Dhfr | 42003 |
| Drosophila melanogaster | Invertebrates | SAM | SAM | ncbigene_symbol | sam | 44534 |
| Drosophila melanogaster | Invertebrates | SAM | SAM | ncbigene_synonym | qkr54B | 36966 |
| Drosophila melanogaster | Invertebrates | SAM | SAM | ncbigene_synonym | sls | 44013 |
| Drosophila melanogaster | Invertebrates | SAM | SAM | ncbigene_synonym | Sam-S | 48552 |
| Drosophila melanogaster | Invertebrates | DHF | DHF | ncbigene_synonym | Hf | 44038 |
| Homo sapiens | Primates | MTHFR | MTHFR | ncbigene_symbol | MTHFR | 4524 |
| Homo sapiens | Primates | CBS | CBS | ncbigene_symbol | CBS | 875 |
| Homo sapiens | Primates | SHMT | SHMT | ncbigene_synonym | SHMT1 | 6470 |
| Homo sapiens | Primates | SHMT | SHMT | ncbigene_synonym | SHMT2 | 6472 |
| Homo sapiens | Primates | SAH | SAH | ncbigene_synonym | ACSM3 | 6296 |
| Homo sapiens | Primates | MS | MS | ncbigene_symbol | MS | 4397 |
| Homo sapiens | Primates | B12 | B12 | ncbigene_synonym | NDUFB3 | 4709 |
| Homo sapiens | Primates | B12 | B12 | ncbigene_synonym | TNFAIP1 | 7126 |
| Homo sapiens | Primates | DHFR | DHFR | ncbigene_symbol | DHFR | 1719 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| pyrimidines | NA | mesh:C030986 | ||
| Cystathionine | Cystathionine | mesh:D003540 | cystathionine | chebi:17755 |
| Folic acid | Folic Acid | mesh:D005492 | folic acid | chebi:27470 |
| Homocysteine | Homocysteine | mesh:D006710 | homocysteine | chebi:17230 |
| Methionine | NA | mesh:D008715 | ||
| Vitamin B12 | Vitamin B 12 | mesh:D014805 | cyanocob(III)alamin | chebi:17439 |
| Vitamin B6 | Vitamin B 6 | mesh:D025101 | vitamin B6 | chebi:27306 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|