The canonical vertebrate Wnt signaling pathway

Schematic of the canonical vertebrate Wnt signaling pathway. Wnt proteins stimulate signaling via the Frizzled receptors, the LRP5/6 co-receptor and the Dishevelled protein to inactivate the β-catenin degradation complex, which consists of Axin, APC and GSK3. DKK1 is a secreted Wnt antagonist. (A) The inhibition of GSK3 activity results in β-catenin stabilization (green arrow) and in the transcriptional activation of target genes mediated by β-catenin in complex with TCF proteins. (B) Wnt signaling also stimulates the HIPK2-dependent elimination of TCF3-mediated target repression, during which β-catenin appears to act as a scaffold for TCF3 phosphorylation. Negative interactions are shown in red; dashed lines represent a hypothetical effect. APC, adenomatous polyposis coli; DKK1, dickkopf 1; Dvl, Dishevelled; GSK3, glycogen synthase kinase 3; HIPK2, homeodomain-interacting protein kinase 2; LRP5/6, low density lipoprotein receptor-related protein 5/6; TCF, T-cell factor.

Publication

Maintaining embryonic stem cell pluripotency with Wnt signaling. (2011) Sergei Y. Sokol. Development. 2011 Oct 15;138(20):4341-4350. Figure: F2. Homo sapiens

Disease mentions