An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis

Shown are key factors mediating the three known pathways of high-affinity iron uptake in this organism: reductive iron uptake, siderophore-iron uptake, and hemoglobin-iron uptake. Gene families encode ferric reductases and multicopper oxidases of the reductive pathway, and only a subset are expressed in an iron-dependent fashion. Ccc2 is a copper transporter required for proper assembly and function of Fet3/iron permease complexes. Genes for each depicted protein are directly activated by Sef1, and genes for Ftr1, Sit1, and Rbt5 are directly repressed by Sfu1.
An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. () Changbin Chen, et al. Cell Host Microbe. ;10(2):118-135. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBA1 3039
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBA2 3040
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBB 3043
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBD 3045
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBD 100187828
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBE1 3046
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBG1 3047
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBG2 3048
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBM 3042
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBQ1 3049
Homo sapiens Primates Hemoglobin HEMOGLOBIN famplex_relations HBZ 3050
Homo sapiens Primates Hemo- HEMO ncbigene_synonym ERVMER34-1 100288413
Homo sapiens Primates Sit1 SIT1 ncbigene_symbol SIT1 27240
Homo sapiens Primates Sit1 SIT1 ncbigene_synonym SLC6A20 54716
Homo sapiens Primates tra TRA ncbigene_symbol TRA 6955
Homo sapiens Primates tra TRA ncbigene_synonym THRA 7067
Homo sapiens Primates tra TRA ncbigene_synonym TRAC 28755
Homo sapiens Primates Cfl1 CFL1 ncbigene_symbol CFL1 1072
Homo sapiens Primates Cfl1 CFL1 ncbigene_synonym VPS72 6944
Homo sapiens Primates Hmx1 HMX1 ncbigene_symbol HMX1 3166
Homo sapiens Primates Ccc2 CCC2 ncbigene_synonym SLC12A1 6557
Saccharomyces cerevisiae S288C Plants and Fungi Sit1 SIT1 ncbigene_symbol SIT1 856644
Saccharomyces cerevisiae S288C Plants and Fungi Sit1 SIT1 ncbigene_synonym RPO21 851415
Saccharomyces cerevisiae S288C Plants and Fungi Cfl1 CFI1 ncbigene_synonym NET1 853369
Saccharomyces cerevisiae S288C Plants and Fungi Ftr1 FTR1 ncbigene_symbol FTR1 856888
Saccharomyces cerevisiae S288C Plants and Fungi Fet3 FET3 ncbigene_symbol FET3 855080
Saccharomyces cerevisiae S288C Plants and Fungi Hmx1 HMX1 ncbigene_symbol HMX1 850902
Saccharomyces cerevisiae S288C Plants and Fungi Ccc2 CCC2 ncbigene_symbol CCC2 851862

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID