Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth
By regulating EGR1, c-JUN and EZH2 expression and activities, PTEN loss suppresses AR transcription factor activity and output, leading to reduced prostate epithelial differentiation and survival. Collaboratively, PTEN loss activates the PI3K/AKT signaling pathway and reduces the AR-regulated FKBP5-PHLPP negative feedback loop to AKT activation, further enhances AKT activation, leading to androgen/AR-independent prostate epithelial proliferation.
Publication
Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. () David J Mulholland, et al. Cancer Cell. ;19(6):792-804. Figure: F8.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | EZH2 | EZH2 | ncbigene_symbol | EZH2 | 2146 |
| Homo sapiens | Primates | EGR1 | EGR1 | ncbigene_symbol | EGR1 | 1958 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | AR | AR | ncbigene_symbol | AR | 367 |
| Homo sapiens | Primates | PTEN | PTEN | ncbigene_symbol | PTEN | 5728 |
| Homo sapiens | Primates | JUN | JUN | ncbigene_symbol | JUN | 3725 |
| Homo sapiens | Primates | JUN | JUN | famplex_relations | JUNB | 3726 |
| Homo sapiens | Primates | JUN | JUN | famplex_relations | JUND | 3727 |
| Homo sapiens | Primates | PHLPP | PHLPP | ncbigene_synonym | PHLPP1 | 23239 |
| Homo sapiens | Primates | P-AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | P-AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | P-AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | FKBP5 | FKBP5 | ncbigene_symbol | FKBP5 | 2289 |
| Homo sapiens | Primates | GSK3 | GSK3 | famplex_relations | GSK3A | 2931 |
| Homo sapiens | Primates | GSK3 | GSK3 | famplex_relations | GSK3B | 2932 |
| Homo sapiens | Primates | MTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |