Variation in the suppressive abilities of Wnt antagonists with respect to canonical and non-canonical Wnt signaling pathways
Variation in the suppressive abilities of Wnt antagonists with respect to canonical and non-canonical Wnt signaling pathways. DKKs inhibit the canonical Wnt pathway by internalizing LRP5/6, whereas SFRPs inhibit both the canonical and non-canonical pathways by binding Wnt ligands or Frizzled.
Publication
Promoter methylation of Wnt antagonists DKK1 and SFRP1 is associated with opposing tumor subtypes in two large populations of colorectal cancer patients. (2011) James B. Rawson, et al. Carcinogenesis. 2011 May;32(5):741-747. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT1 | 7471 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2 | 7472 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT2B | 7482 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3 | 7473 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT3A | 89780 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT4 | 54361 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT6 | 7475 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7A | 7476 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT7B | 7477 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8A | 7478 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT8B | 7479 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9A | 7483 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT9B | 7484 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10A | 80326 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT10B | 7480 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT11 | 7481 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT16 | 51384 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5A | 7474 |
| Homo sapiens | Primates | Wnt | WNT | famplex_relations | WNT5B | 81029 |
| Homo sapiens | Primates | LRP5/6 | LRP6 | ncbigene_symbol | LRP6 | 4040 |
| Homo sapiens | Primates | LRP5/6 | LRP5 | ncbigene_symbol | LRP5 | 4041 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD1 | 8321 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD10 | 11211 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD2 | 2535 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD3 | 7976 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD4 | 8322 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD5 | 7855 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD6 | 8323 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD7 | 8324 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD8 | 8325 |
| Homo sapiens | Primates | Frizzled | FZD | famplex_relations | FZD9 | 8326 |
| Homo sapiens | Primates | Axin | AXIN | ncbigene_synonym | AXIN1 | 8312 |
| Homo sapiens | Primates | Axin | AXIN | famplex_relations | AXIN2 | 8313 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | CamKIl | CAMKII | ncbigene_synonym | CAMK2G | 818 |
| Homo sapiens | Primates | JNK | JNK | ncbigene_synonym | MAPK8 | 5599 |
| Homo sapiens | Primates | JNK | JNK | famplex_relations | MAPK9 | 5601 |
| Homo sapiens | Primates | JNK | JNK | famplex_relations | MAPK10 | 5602 |
| Homo sapiens | Primates | GSK3B | GSK3B | ncbigene_symbol | GSK3B | 2932 |
| Drosophila melanogaster | Invertebrates | Wnt | WNT | ncbigene_synonym | Wnt5 | 32838 |
| Drosophila melanogaster | Invertebrates | Wnt | WNT | ncbigene_synonym | Wnt4 | 34007 |
| Drosophila melanogaster | Invertebrates | Wnt | WNT | ncbigene_synonym | wg | 34009 |
| Drosophila melanogaster | Invertebrates | Wnt | WNT | ncbigene_synonym | Wnt2 | 35975 |
| Drosophila melanogaster | Invertebrates | LRP5/6 | LRP5/6 | ncbigene_synonym | arr | 44279 |
| Drosophila melanogaster | Invertebrates | Frizzled | FRIZZLED | ncbigene_synonym | fz | 45307 |
| Drosophila melanogaster | Invertebrates | Axin | AXIN | ncbigene_synonym | Axn | 43565 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_symbol | Apc | 44642 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Apc2 | 42871 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Fs(3)Apc | 49116 |
| Drosophila melanogaster | Invertebrates | CamKIl | CAMKII | ncbigene_symbol | CaMKII | 43828 |
| Drosophila melanogaster | Invertebrates | JNK | JNK | ncbigene_synonym | bsk | 44801 |
| Drosophila melanogaster | Invertebrates | GSK3B | GSK3B | ncbigene_synonym | sgg | 31248 |
| Drosophila melanogaster | Invertebrates | GSK3B | GSK3B | ncbigene_synonym | gskt | 318552 |
| Drosophila melanogaster | Invertebrates | B-cat | B-CAT | ncbigene_synonym | arm | 31151 |
| Drosophila melanogaster | Invertebrates | Ca?- | CA | ncbigene_symbol | ca | 43518 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | CkIIbeta | 32132 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Andorra | 32798 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Anp | 43595 |
| Drosophila melanogaster | Invertebrates | and | AND | ncbigene_synonym | Acam | 44913 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|