The PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays

Schematic representation of the PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays.
The PI3K/mTOR signaling pathway highlighting the phosphorylation sites tested in our cellular and biochemical assays
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Design, synthesis, and structure-activity relationships of 3-ethynyl-1H-indazoles as inhibitors of Phosphatidylinositol 3-kinase signaling pathway. () Elisa Barile, et al. J Med Chem. ;53(23):8368-8375. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents p110a P110A ncbigene_synonym Pik3ca 18706
Mus musculus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK1 PDK1 ncbigene_synonym Pdpk1 18607
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PRAS40 PRAS40 ncbigene_synonym Akt1s1 67605
Mus musculus Rodents S6K S6K ncbigene_synonym Rps6kb1 72508
Mus musculus Rodents PDCD4 PDCD4 ncbigene_symbol Pdcd4 18569
Mus musculus Rodents PI(4,5)P PI4 ncbigene_synonym Serpina1d 20703
Mus musculus Rodents rictor RICTOR ncbigene_symbol Rictor 78757
Mus musculus Rodents GBL GBL ncbigene_synonym Mlst8 56716
Rattus norvegicus Rodents PI3KA PI3KA ncbigene_synonym Pik3r1 25513
Rattus norvegicus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 116551
Rattus norvegicus Rodents PTEN PTEN ncbigene_symbol Pten 50557
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Rattus norvegicus Rodents AKT AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents PRAS40 PRAS40 ncbigene_synonym Akt1s1 292887
Rattus norvegicus Rodents PDCD4 PDCD4 ncbigene_symbol Pdcd4 64031
Rattus norvegicus Rodents rictor RICTOR ncbigene_symbol Rictor 310131
Rattus norvegicus Rodents GBL GBL ncbigene_synonym Mlst8 64226
Bos taurus Mammals PDK1 PDK1 ncbigene_symbol PDK1 528655
Bos taurus Mammals PTEN PTEN ncbigene_symbol PTEN 540786
Bos taurus Mammals MTOR MTOR ncbigene_symbol MTOR 100139219
Bos taurus Mammals AKT AKT ncbigene_synonym AKT1 280991
Bos taurus Mammals PDCD4 PDCD4 ncbigene_symbol PDCD4 506724
Bos taurus Mammals rictor RICTOR ncbigene_symbol RICTOR 527459
Bos taurus Mammals GBL GBL ncbigene_synonym MLST8 535236
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Growthfactor GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates PI3KA PI3KA ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates mTORC2 MTORC2 famplex_relations RICTOR 253260
Homo sapiens Primates mTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates PRAS40 PRAS40 ncbigene_synonym AKT1S1 84335
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates PDCD4 PDCD4 ncbigene_symbol PDCD4 27250
Homo sapiens Primates PI(4,5)P PI4 ncbigene_synonym SERPINA4 5267
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates AKT AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates PRAS40 PRAS40 ncbigene_symbol PRAS40 26067067
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Drosophila melanogaster Invertebrates PDCD4 PDCD4 ncbigene_symbol Pdcd4 32337
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Tie 38559
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym InR 42549
Drosophila melanogaster Invertebrates rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates GBL GBL ncbigene_synonym Lst8 31903

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID