RAS signaling to the PI3K pathway

RAS signaling to the PI3K pathway.
RAS signaling to the PI3K pathway
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Publication

RAS Interaction with PI3K. (2011) Esther Castellano, et al. Genes Cancer. 2011 Mar;2(3):261-274. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents GPCR GPCR ncbigene_synonym Gpbar1 227289
Mus musculus Rodents GRB2 GRB2 ncbigene_symbol Grb2 14784
Mus musculus Rodents p85) P85 ncbigene_synonym Ecm1 13601
Mus musculus Rodents p85) P85 ncbigene_synonym Ppp1r13b 21981
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents p110a P110A ncbigene_synonym Pik3ca 18706
Mus musculus Rodents RAS RAS ncbigene_symbol ras 19412
Mus musculus Rodents RAS RAS ncbigene_synonym Hras 15461
Mus musculus Rodents RAS RAS ncbigene_synonym Kras 16653
Mus musculus Rodents RAS RAS ncbigene_synonym Rem1 19700
Mus musculus Rodents GAPS GAPS ncbigene_synonym Gart 14450
Mus musculus Rodents RAC RAC ncbigene_synonym Akt1 11651
Mus musculus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK1 PDK1 ncbigene_synonym Pdpk1 18607
Mus musculus Rodents IRS-1 IRS-1 ncbigene_synonym Irs1 16367
Mus musculus Rodents (P70S6K) P70S6K ncbigene_synonym Rps6kb1 72508
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents GBL GBL ncbigene_synonym Mlst8 56716
Mus musculus Rodents Rictor RICTOR ncbigene_symbol Rictor 78757
Mus musculus Rodents TSC2 TSC2 ncbigene_symbol Tsc2 22084
Mus musculus Rodents GSK-3 GSK-3 ncbigene_synonym Gsk3b 56637
Mus musculus Rodents Raptor RAPTOR ncbigene_synonym Rptor 74370
Mus musculus Rodents BAD BAD ncbigene_symbol Bad 12015
Mus musculus Rodents Bcl-2 BCL-2 ncbigene_synonym Bcl2 12043
Mus musculus Rodents p27 P27 ncbigene_synonym Cdkn1b 12576
Mus musculus Rodents p27 P27 ncbigene_synonym Dctn6 22428
Mus musculus Rodents p27 P27 ncbigene_synonym Psmd9 67151
Mus musculus Rodents FasL FASL ncbigene_symbol Fasl 14103
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates Growthfactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates GPCR GPCR ncbigene_synonym FZD4 8322
Homo sapiens Primates GPCR GPCR ncbigene_synonym NMUR1 10316
Homo sapiens Primates GPCR GPCR ncbigene_synonym LPAR3 23566
Homo sapiens Primates GPCR GPCR ncbigene_synonym LGR6 59352
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX3 117195
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX4 117196
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR151 134391
Homo sapiens Primates GPCR GPCR ncbigene_synonym OXER1 165140
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPRC6A 222545
Homo sapiens Primates GPCR GPCR ncbigene_synonym MRGPRX1 259249
Homo sapiens Primates GPCR GPCR ncbigene_synonym VN1R17P 441931
Homo sapiens Primates GPCR GPCR ncbigene_synonym GPR166P 442206
Homo sapiens Primates GPCR GPCR famplex_relations GRM1 2911
Homo sapiens Primates GPCR GPCR famplex_relations GRM2 2912
Homo sapiens Primates GPCR GPCR famplex_relations GRM3 2913
Homo sapiens Primates GPCR GPCR famplex_relations GRM4 2914
Homo sapiens Primates GPCR GPCR famplex_relations GRM5 2915
Homo sapiens Primates GPCR GPCR famplex_relations GRM6 2916
Homo sapiens Primates GPCR GPCR famplex_relations GRM7 2917
Homo sapiens Primates GPCR GPCR famplex_relations GRM8 2918
Homo sapiens Primates GPCR GPCR famplex_relations CASR 846
Homo sapiens Primates GPCR GPCR famplex_relations GABBR1 2550
Homo sapiens Primates GPCR GPCR famplex_relations GABBR2 9568
Homo sapiens Primates GPCR GPCR famplex_relations GPR156 165829
Homo sapiens Primates GPCR GPCR famplex_relations GPR158 57512
Homo sapiens Primates GPCR GPCR famplex_relations GPR179 440435
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5A 9052
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5B 51704
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5C 55890
Homo sapiens Primates GPCR GPCR famplex_relations GPRC5D 55507
Homo sapiens Primates GRB2 GRB2 ncbigene_symbol GRB2 2885
Homo sapiens Primates GAB GAB ncbigene_synonym A1BG 1
Homo sapiens Primates sos SOS ncbigene_synonym XYLT2 64132
Homo sapiens Primates sos SOS famplex_relations SOS1 6654
Homo sapiens Primates sos SOS famplex_relations SOS2 6655
Homo sapiens Primates p85) P85 ncbigene_synonym PIK3R1 5295
Homo sapiens Primates p85) P85 ncbigene_synonym PIK3R2 5296
Homo sapiens Primates p85) P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p85) P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates p85) P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates p85) P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates p110a P110A ncbigene_synonym PIK3CA 5290
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates GOR GOR ncbigene_synonym REXO1L1P 254958
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates RAC RAC ncbigene_synonym AKT1 207
Homo sapiens Primates RAC RAC famplex_relations RAC1 5879
Homo sapiens Primates RAC RAC famplex_relations RAC2 5880
Homo sapiens Primates RAC RAC famplex_relations RAC3 5881
Homo sapiens Primates RAC RAC famplex_relations RHOG 391
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates IRS-1 IRS1 ncbigene_symbol IRS1 3667
Homo sapiens Primates (P70S6K) P70S6K ncbigene_synonym RPS6KB1 6198
Homo sapiens Primates (P70S6K) P70S6K famplex_relations RPS6KB2 6199
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates GBL GBL ncbigene_synonym MLST8 64223
Homo sapiens Primates Rictor RICTOR ncbigene_symbol RICTOR 253260
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates GSK-3 GSK3 famplex_relations GSK3A 2931
Homo sapiens Primates GSK-3 GSK3 famplex_relations GSK3B 2932
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates Bcl-2 BCL-2 ncbigene_synonym BCL2 596
Homo sapiens Primates p27 P27 ncbigene_synonym IFI27 3429
Homo sapiens Primates p27 P27 ncbigene_synonym PSMD9 5715
Homo sapiens Primates p27 P27 ncbigene_synonym ZNRD2 10534
Homo sapiens Primates p27 P27 ncbigene_synonym DCTN6 10671
Homo sapiens Primates p27 P27 ncbigene_synonym TMED7 51014
Homo sapiens Primates p27 P27 ncbigene_synonym H3P23 115482696
Homo sapiens Primates FasL FASL ncbigene_synonym FASLG 356
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Tie 38559
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates RTK RTK ncbigene_synonym InR 42549
Drosophila melanogaster Invertebrates GPCR GPCR ncbigene_synonym Oamb 43982
Drosophila melanogaster Invertebrates GRB2 GRB2 ncbigene_synonym drk 36497
Drosophila melanogaster Invertebrates sos SOS ncbigene_symbol Sos 34790
Drosophila melanogaster Invertebrates p85) P85 ncbigene_synonym Myb 32543
Drosophila melanogaster Invertebrates p85) P85 ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates p85) P85 ncbigene_synonym Taf5 47900
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates RAS RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates RAS RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C1 34284
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-R2 36041
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C3 39733
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-R1 40305
Drosophila melanogaster Invertebrates PKA PKA ncbigene_synonym Pka-C2 43644
Drosophila melanogaster Invertebrates GOR GOR ncbigene_symbol gor 46240
Drosophila melanogaster Invertebrates GOR GOR ncbigene_synonym grb 44164
Drosophila melanogaster Invertebrates GT GT ncbigene_symbol gt 31227
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKC PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates RAC RAC ncbigene_synonym Rac1 38146
Drosophila melanogaster Invertebrates RAC RAC ncbigene_synonym Rac2 38831
Drosophila melanogaster Invertebrates RAC RAC ncbigene_synonym Akt 41957
Drosophila melanogaster Invertebrates RAC RAC ncbigene_synonym Mtl 43319
Drosophila melanogaster Invertebrates PDK1 PDK1 ncbigene_symbol Pdk1 38017
Drosophila melanogaster Invertebrates (P70S6K) P70S6K ncbigene_synonym S6k 38654
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates GBL GBL ncbigene_synonym Lst8 31903
Drosophila melanogaster Invertebrates Rictor RICTOR ncbigene_symbol rictor 32919
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates GSK-3 GSK-3 ncbigene_synonym sgg 31248
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates BAD BAD ncbigene_synonym cass 35053
Drosophila melanogaster Invertebrates Bcl-2 BCL-2 ncbigene_synonym Debcl 53585
Drosophila melanogaster Invertebrates p27 P27 ncbigene_synonym DCTN6-p27 35195
Drosophila melanogaster Invertebrates p27 P27 ncbigene_synonym dap 36001
Drosophila melanogaster Invertebrates p27 P27 ncbigene_synonym CG9588 41672
Drosophila melanogaster Invertebrates Cycle CYCLE ncbigene_synonym CycE 34924
Drosophila melanogaster Invertebrates Cycle CYCLE ncbigene_synonym cyc 40162
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913

Chemical mentions

Word Match MeSH Name ChEBI
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167

Disease mentions

Word Match MeSH Name DOID
Cancer NA