Comparison of cAMP-PKA and MAPK signaling cascades in C

Comparison of cAMP-PKA and MAPK signaling cascades in C. albicans, C. neoformans, and A. fumigatus. The cAMP-PKA signaling cascade and MAPK cascade represent two key morphogenetic signaling pathways conserved in these species. The MAPK signaling cascades modulating morphogenesis in A. fumigatus (the HOG-MAPK pathway and cell wall integrity MAPK pathway) are distinct from the MAPK module depicted in this figure. (Top) The cAMP-PKA pathway. (Bottom) The MAPK cascade. Corresponding colors between pathways indicate orthologous proteins between the species. Gray arrows indicate that links between certain factors in this pathway have not yet been established.
Comparison of cAMP-PKA and MAPK signaling cascades in C
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Publication

Regulatory Circuitry Governing Fungal Development, Drug Resistance, and Disease. (2011) Rebecca S. Shapiro, et al. Microbiol Mol Biol Rev. 2011 Jun;75(2):213-267. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Gpr1 GPR1 ncbigene_synonym CMKLR2 2825
Homo sapiens Primates Gpr4 GPR4 ncbigene_symbol GPR4 2828
Homo sapiens Primates Gpa2 GPA2 ncbigene_synonym GPHA2 170589
Homo sapiens Primates Gpa1 GPA1 ncbigene_synonym CGA 1081
Homo sapiens Primates RasA RASA ncbigene_synonym RASA1 5921
Homo sapiens Primates RasA RASA famplex_relations RASA2 5922
Homo sapiens Primates RasA RASA famplex_relations RASA3 22821
Homo sapiens Primates Cac1 CAC1 ncbigene_synonym TMEM54 113452
Homo sapiens Primates Cac1 CAC1 ncbigene_synonym CACUL1 143384
Homo sapiens Primates Acal ACA1 ncbigene_synonym SNORA1 677792
Homo sapiens Primates ATP ATP ncbigene_synonym ATP8A2 51761
Homo sapiens Primates Tpk1 TPK1 ncbigene_symbol TPK1 27010
Homo sapiens Primates PKA PKA famplex_relations PRKAR1A 5573
Homo sapiens Primates PKA PKA famplex_relations PRKAR1B 5575
Homo sapiens Primates PKA PKA famplex_relations PRKAR2A 5576
Homo sapiens Primates PKA PKA famplex_relations PRKAR2B 5577
Homo sapiens Primates PKA PKA famplex_relations PRKACA 5566
Homo sapiens Primates PKA PKA famplex_relations PRKACB 5567
Homo sapiens Primates PKA PKA famplex_relations PRKACG 5568
Homo sapiens Primates Pkr1 PKR1 ncbigene_synonym PROKR1 10887
Homo sapiens Primates Efg1 EFG1 ncbigene_synonym GFM1 85476
Homo sapiens Primates Rim RIM ncbigene_synonym RBBP8 5932
Homo sapiens Primates Rim RIM ncbigene_synonym RIMS1 22999
Homo sapiens Primates Nrg NRG famplex_relations NRG1 3084
Homo sapiens Primates Nrg NRG famplex_relations NRG2 9542
Homo sapiens Primates Nrg NRG famplex_relations NRG3 10718
Homo sapiens Primates Nrg NRG famplex_relations NRG4 145957
Homo sapiens Primates Ste20 STE20 ncbigene_synonym STK24 8428
Homo sapiens Primates Cla4 CLA4 ncbigene_synonym ITPR1 3708
Homo sapiens Primates Cek2 CEK2 ncbigene_synonym FGFR3 2261
Saccharomyces cerevisiae S288C Plants and Fungi Gpr1 GPR1 ncbigene_symbol GPR1 851527
Saccharomyces cerevisiae S288C Plants and Fungi Gpa2 GPA2 ncbigene_symbol GPA2 856741
Saccharomyces cerevisiae S288C Plants and Fungi Gpa1 GPA1 ncbigene_symbol GPA1 856394
Saccharomyces cerevisiae S288C Plants and Fungi Ras1 RAS1 ncbigene_symbol RAS1 854268
Saccharomyces cerevisiae S288C Plants and Fungi Srv2 SRV2 ncbigene_symbol SRV2 855584
Saccharomyces cerevisiae S288C Plants and Fungi Cac1 CAC1 ncbigene_synonym RLF2 856129
Saccharomyces cerevisiae S288C Plants and Fungi Acal ACA1 ncbigene_symbol ACA1 856769
Saccharomyces cerevisiae S288C Plants and Fungi Tpk1 TPK1 ncbigene_symbol TPK1 853275
Saccharomyces cerevisiae S288C Plants and Fungi Tpk2 TPK2 ncbigene_symbol TPK2 855898
Saccharomyces cerevisiae S288C Plants and Fungi Bcyl BCY1 ncbigene_symbol BCY1 854778
Saccharomyces cerevisiae S288C Plants and Fungi Pkr1 PKR1 ncbigene_symbol PKR1 855153
Saccharomyces cerevisiae S288C Plants and Fungi Efg1 EFG1 ncbigene_symbol EFG1 853188
Saccharomyces cerevisiae S288C Plants and Fungi Rim101 RIM101 ncbigene_symbol RIM101 856358
Saccharomyces cerevisiae S288C Plants and Fungi Ste20 STE20 ncbigene_symbol STE20 856382
Saccharomyces cerevisiae S288C Plants and Fungi Cst20 CST20 ncbigene_synonym YRB1 851565
Saccharomyces cerevisiae S288C Plants and Fungi Cla4 CLA4 ncbigene_symbol CLA4 855418
Saccharomyces cerevisiae S288C Plants and Fungi Ste11 STE11 ncbigene_symbol STE11 851076
Saccharomyces cerevisiae S288C Plants and Fungi Ste7 STE7 ncbigene_symbol STE7 851396
Saccharomyces cerevisiae S288C Plants and Fungi Cph1 CPH1 ncbigene_synonym CPR1 851733

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID