Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell

Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell. A fully interactive version of this pathway is available online at PharmGKB at http://www.pharmgkb.org/do/serve?objId=PA165292163&objCls=Pathway. PK pathway, pharmacokinetics pathway; ROS, reactive oxygen species.
Graphical representation of the candidate genes involved in the pharmacodynamics of doxorubicin in a stylized cancer cell
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Publication

Doxorubicin pathways: pharmacodynamics and adverse effects. () Caroline F. Thorn, et al. Pharmacogenet Genomics. ;21(7):440-446. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates SLC22A16 SLC22A16 ncbigene_symbol SLC22A16 85413
Homo sapiens Primates ABCB1 ABCB1 ncbigene_symbol ABCB1 5243
Homo sapiens Primates SOD1 SOD1 ncbigene_symbol SOD1 6647
Homo sapiens Primates RALBP1) RALBP1 ncbigene_symbol RALBP1 10928
Homo sapiens Primates RALBP1) RALBP1 ncbigene_synonym REPS1 85021
Homo sapiens Primates ABCG2 ABCG2 ncbigene_symbol ABCG2 9429
Homo sapiens Primates ABCC2 ABCC2 ncbigene_symbol ABCC2 1244
Homo sapiens Primates ABCC1 ABCC1 ncbigene_symbol ABCC1 4363
Homo sapiens Primates GPX1 GPX1 ncbigene_symbol GPX1 2876
Homo sapiens Primates NOS3 NOS3 ncbigene_symbol NOS3 4846
Homo sapiens Primates NOS3 NOS3 ncbigene_synonym NANOS3 342977
Homo sapiens Primates XDH XDH ncbigene_symbol XDH 7498
Homo sapiens Primates XDH XDH ncbigene_synonym SORD 6652
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA1 5682
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA2 5683
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA3 5684
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA4 5685
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA5 5686
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA6 5687
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA7 5688
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMA8 143471
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB1 5689
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB10 5699
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB2 5690
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB3 5691
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB4 5692
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB5 5693
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB6 5694
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB7 5695
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB8 5696
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMB9 5698
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC1 5700
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC2 5701
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC3 5702
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC4 5704
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC5 5705
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMC6 5706
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD1 5707
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD10 5716
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD11 5717
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD12 5718
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD13 5719
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD14 10213
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD2 5708
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD3 5709
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD4 5710
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD5 5711
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD6 9861
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD7 5713
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD8 5714
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMD9 5715
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME1 5720
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME2 5721
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSME3 10197
Homo sapiens Primates Proteasome PROTEASOME famplex_relations PSMF1 9491
Homo sapiens Primates Proteasome PROTEASOME famplex_relations SEM1 7979
Homo sapiens Primates Proteasome PROTEASOME famplex_relations USP5 8078
Homo sapiens Primates NFKB1 NFKB1 ncbigene_symbol NFKB1 4790
Homo sapiens Primates NFKB1 NFKB1 famplex_relations NFKB2 4791
Homo sapiens Primates MLH1 MLH1 ncbigene_symbol MLH1 4292
Homo sapiens Primates MSH2 MSH2 ncbigene_symbol MSH2 4436
Homo sapiens Primates TOP2A TOP2A ncbigene_symbol TOP2A 7153
Homo sapiens Primates ERCC2 ERCC2 ncbigene_symbol ERCC2 2068
Homo sapiens Primates TP53 TP53 ncbigene_symbol TP53 7157
Homo sapiens Primates CAT CAT ncbigene_symbol CAT 847
Homo sapiens Primates CAT CAT ncbigene_synonym CRAT 1384
Homo sapiens Primates CAT CAT ncbigene_synonym GLYAT 10249
Mus musculus Rodents SLC22A16 SLC22A16 ncbigene_symbol Slc22a16 70840
Mus musculus Rodents ABCB1 ABCB1 ncbigene_synonym Abcb1b 18669
Mus musculus Rodents SOD1 SOD1 ncbigene_symbol Sod1 20655
Mus musculus Rodents RALBP1) RALBP1 ncbigene_symbol Ralbp1 19765
Mus musculus Rodents ABCG2 ABCG2 ncbigene_symbol Abcg2 26357
Mus musculus Rodents ABCC2 ABCC2 ncbigene_symbol Abcc2 12780
Mus musculus Rodents ABCC1 ABCC1 ncbigene_symbol Abcc1 17250
Mus musculus Rodents GPX1 GPX1 ncbigene_symbol Gpx1 14775
Mus musculus Rodents NOS3 NOS3 ncbigene_symbol Nos3 18127
Mus musculus Rodents NOS3 NOS3 ncbigene_synonym Nanos3 244551
Mus musculus Rodents XDH XDH ncbigene_symbol Xdh 22436
Mus musculus Rodents XDH XDH ncbigene_synonym Sord 20322
Mus musculus Rodents PK PK ncbigene_symbol pk 18745
Mus musculus Rodents NFKB1 NFKB1 ncbigene_symbol Nfkb1 18033
Mus musculus Rodents MLH1 MLH1 ncbigene_symbol Mlh1 17350
Mus musculus Rodents MSH2 MSH2 ncbigene_symbol Msh2 17685
Mus musculus Rodents TOP2A TOP2A ncbigene_symbol Top2a 21973
Mus musculus Rodents ERCC2 ERCC2 ncbigene_symbol Ercc2 13871
Mus musculus Rodents TP53 TP53 ncbigene_synonym Trp53 22059
Mus musculus Rodents CAT CAT ncbigene_symbol Cat 12359
Mus musculus Rodents CAT CAT ncbigene_synonym cac 12285
Mus musculus Rodents CAT CAT ncbigene_synonym Mip 17339
Mus musculus Rodents CAT CAT ncbigene_synonym Trpv6 64177
Mus musculus Rodents CAT CAT ncbigene_synonym Glyat 107146
Rattus norvegicus Rodents SLC22A16 SLC22A16 ncbigene_symbol Slc22a16 682934
Rattus norvegicus Rodents ABCB1 ABCB1 ncbigene_synonym Abcb1b 24646
Rattus norvegicus Rodents ABCB1 ABCB1 ncbigene_synonym Abcb1a 170913
Rattus norvegicus Rodents SOD1 SOD1 ncbigene_symbol Sod1 24786
Rattus norvegicus Rodents RALBP1) RALBP1 ncbigene_symbol Ralbp1 84014
Rattus norvegicus Rodents ABCG2 ABCG2 ncbigene_symbol Abcg2 312382
Rattus norvegicus Rodents ABCC2 ABCC2 ncbigene_symbol Abcc2 25303
Rattus norvegicus Rodents ABCC1 ABCC1 ncbigene_symbol Abcc1 24565
Rattus norvegicus Rodents GPX1 GPX1 ncbigene_symbol Gpx1 24404
Rattus norvegicus Rodents NOS3 NOS3 ncbigene_symbol Nos3 24600
Rattus norvegicus Rodents XDH XDH ncbigene_symbol Xdh 497811
Rattus norvegicus Rodents XDH XDH ncbigene_synonym Sord 24788
Rattus norvegicus Rodents NFKB1 NFKB1 ncbigene_symbol Nfkb1 81736
Rattus norvegicus Rodents MLH1 MLH1 ncbigene_symbol Mlh1 81685
Rattus norvegicus Rodents MSH2 MSH2 ncbigene_symbol Msh2 81709
Rattus norvegicus Rodents TOP2A TOP2A ncbigene_symbol Top2a 360243
Rattus norvegicus Rodents ERCC2 ERCC2 ncbigene_symbol Ercc2 308415
Rattus norvegicus Rodents TP53 TP53 ncbigene_symbol Tp53 24842
Rattus norvegicus Rodents CAT CAT ncbigene_symbol Cat 24248
Danio rerio Vertebrates SLC22A16 SLC22A16 ncbigene_symbol slc22a16 557279
Danio rerio Vertebrates SOD1 SOD1 ncbigene_symbol sod1 30553
Danio rerio Vertebrates RALBP1) RALBP1 ncbigene_symbol ralbp1 404612
Danio rerio Vertebrates ABCC2 ABCC2 ncbigene_symbol abcc2 393561
Danio rerio Vertebrates ABCC1 ABCC1 ncbigene_symbol abcc1 100002010
Danio rerio Vertebrates GPX1 GPX1 ncbigene_synonym gpx1a 352926
Danio rerio Vertebrates XDH XDH ncbigene_symbol xdh 560486
Danio rerio Vertebrates XDH XDH ncbigene_synonym aox5 64265
Danio rerio Vertebrates NFKB1 NFKB1 ncbigene_symbol nfkb1 565756
Danio rerio Vertebrates MLH1 MLH1 ncbigene_symbol mlh1 393632
Danio rerio Vertebrates MSH2 MSH2 ncbigene_symbol msh2 406845
Danio rerio Vertebrates TOP2A TOP2A ncbigene_symbol top2a 323733
Danio rerio Vertebrates ERCC2 ERCC2 ncbigene_symbol ercc2 393900
Danio rerio Vertebrates TP53 TP53 ncbigene_symbol tp53 30590
Danio rerio Vertebrates CAT CAT ncbigene_symbol cat 30068

Chemical mentions

Word Match MeSH Name ChEBI
Doxorubicin Doxorubicin mesh:D004317 doxorubicin chebi:28748

Disease mentions

Word Match MeSH Name DOID