Simplified diagram of Kynurenine pathway: during neuroinflammation, 95% of the dietary tryptophan is metabolized along the KP within the brain
Simplified diagram of Kynurenine pathway: during neuroinflammation, 95% of the dietary tryptophan is metabolized along the KP within the brain. The remaining 5% serves as a precursor to the synthesis of the neurotransmitter serotonin. IDO catalyses the initial and rate-limiting step in the degradation of tryptophan through KP that ultimately leads to the production of nicotinamide.
Publication
The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson's Disease. (2011) Anna Zinger, et al. Parkinsons Dis. 2011;2011:716859. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Mus musculus | Rodents | (IDO) | IDO | ncbigene_synonym | Ido1 | 15930 |
| Mus musculus | Rodents | (KAT) | KAT | ncbigene_synonym | Nek1 | 18004 |
| Mus musculus | Rodents | (KAT) | KAT | ncbigene_synonym | Katnb1 | 74187 |
| Mus musculus | Rodents | (KAT) | KAT | ncbigene_synonym | Tstd1 | 226654 |
| Mus musculus | Rodents | (KMO) | KMO | ncbigene_symbol | Kmo | 98256 |
| Mus musculus | Rodents | (3-HAO) | 3HAO | ncbigene_synonym | Haao | 107766 |
| Mus musculus | Rodents | (ACMSD) | ACMSD | ncbigene_symbol | Acmsd | 266645 |
| Mus musculus | Rodents | (QPRT) | QPRT | ncbigene_symbol | Qprt | 67375 |
| Homo sapiens | Primates | (IDO) | IDO | ncbigene_synonym | IDO1 | 3620 |
| Homo sapiens | Primates | (KAT) | KAT | ncbigene_synonym | KATNB1 | 10300 |
| Homo sapiens | Primates | (KAT) | KAT | ncbigene_synonym | F11R | 50848 |
| Homo sapiens | Primates | (KAT) | KAT | ncbigene_synonym | TSTD1 | 100131187 |
| Homo sapiens | Primates | (KMO) | KMO | ncbigene_symbol | KMO | 8564 |
| Homo sapiens | Primates | (3-HAO) | 3HAO | ncbigene_synonym | HAAO | 23498 |
| Homo sapiens | Primates | (ACMSD) | ACMSD | ncbigene_symbol | ACMSD | 130013 |
| Homo sapiens | Primates | (QPRT) | QPRT | ncbigene_symbol | QPRT | 23475 |
| Rattus norvegicus | Rodents | (IDO) | IDO | ncbigene_synonym | Ido1 | 66029 |
| Rattus norvegicus | Rodents | (KMO) | KMO | ncbigene_symbol | Kmo | 59113 |
| Rattus norvegicus | Rodents | (ACMSD) | ACMSD | ncbigene_symbol | Acmsd | 171385 |
| Rattus norvegicus | Rodents | (QPRT) | QPRT | ncbigene_symbol | Qprt | 293504 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Picolinic acid | picolinic acid | mesh:C030614 | picolinic acid | chebi:28747 |
| 5-hydroxy-anthranilic acid | NA | mesh:C031385 | ||
| Anthranilic acid | NA | mesh:C031385 | ||
| 2-amini-3-carboxymuconate | NA | mesh:C558759 | ||
| 2-amino-3-carboxymuconate | NA | mesh:C558759 | ||
| Kynurenic acid | NA | mesh:D007736 | ||
| Nicotinamide | Niacinamide | mesh:D009536 | nicotinamide | chebi:17154 |
| Tryptophan | Tryptophan | mesh:D014364 | L-tryptophan | chebi:16828 |
| 3-hydroxyanthranilic acid | NA | mesh:D015095 | ||
| Quinolinate phosphoribosyl | NA | mesh:D017378 | ||
| Quinolinic acid | NA | mesh:D017378 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|