Fanconi anemia pathway and ICL repair: implications for cancer therapy

Hypothetical localization of the different FA subcomplexes at a replication fork encountering an interstrand crosslink (red line). The core complex together with the E2 ligase UBE2, mono-ubiquitylate FANCI and FANCD2 (ID complex), thus triggering its association to damaged chromatin. Several FA proteins are phosphorylated in response to DNA damage by the checkpoint kinases ATM, ATR and CHK1. In addition, FANCM and FANCG are phosphorylated in mitosis (See text for details). Note: a color version of the figure is available online.
Fanconi anemia pathway and ICL repair: implications for cancer therapy
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Publication

The Fanconi anemia pathway and ICL repair: implications for cancer therapy. () Lily C Wang, et al. Crit Rev Biochem Mol Biol. ;45(5):424-439. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Danio rerio Vertebrates ATR ATR ncbigene_symbol atr 567770
Danio rerio Vertebrates UBE2T UBE2T ncbigene_symbol ube2t 768152
Danio rerio Vertebrates ATM ATM ncbigene_symbol atm 403064
Danio rerio Vertebrates FANCI FANCI ncbigene_symbol fanci 324185
Danio rerio Vertebrates FANCL FANCL ncbigene_symbol fancl 406255
Danio rerio Vertebrates FANCD2 FANCD2 ncbigene_symbol fancd2 394241
Danio rerio Vertebrates FAAP24 FAAP24 ncbigene_symbol faap24 559470
Danio rerio Vertebrates FAAP100 FAAP100 ncbigene_symbol faap100 100001169
Danio rerio Vertebrates USP1 USP1 ncbigene_symbol usp1 322007
Danio rerio Vertebrates FANCD1 FANCD1 ncbigene_synonym brca2 566758
Danio rerio Vertebrates FANCJ FANCJ ncbigene_synonym brip1 794038
Danio rerio Vertebrates FANCN FANCN ncbigene_synonym palb2 558923
Danio rerio Vertebrates RAD51C RAD51C ncbigene_symbol rad51c 450081
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates CHK1 CHK1 ncbigene_synonym CHEK1 1111
Homo sapiens Primates UBE2T UBE2T ncbigene_symbol UBE2T 29089
Homo sapiens Primates ATM ATM ncbigene_symbol ATM 472
Homo sapiens Primates FANCI FANCI ncbigene_symbol FANCI 55215
Homo sapiens Primates FANCL FANCL ncbigene_symbol FANCL 55120
Homo sapiens Primates FANCD2 FANCD2 ncbigene_symbol FANCD2 2177
Homo sapiens Primates FAAP24 FAAP24 ncbigene_symbol FAAP24 91442
Homo sapiens Primates FAAP100 FAAP100 ncbigene_symbol FAAP100 80233
Homo sapiens Primates UbP UBP ncbigene_synonym USP1 7398
Homo sapiens Primates UbP UBP ncbigene_synonym USP3 9960
Homo sapiens Primates FANCD1 FANCD1 ncbigene_synonym BRCA2 675
Homo sapiens Primates FANCJ FANCJ ncbigene_synonym BRIP1 83990
Homo sapiens Primates FANCN FANCN ncbigene_synonym PALB2 79728
Homo sapiens Primates RAD51C RAD51C ncbigene_symbol RAD51C 5889

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Breast cancer NA
Fanconi anemia NA