Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression

Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression. In osteoblasts, in the absence of IGF1/insulin signaling, Foxo1 binds to Runx2 and inhibits Runx2 DNA binding to the OSE2 sites of the Bglap2 promoter, resulting in a reduction of osteocalcin (Ocn) expression. In the presence of IGF1/insulin signaling, Foxo1 is phosphorylated via the PI3K/AKT pathway and translocated from the nucleus to the cytoplasm where it binds to the 14-3-3 protein, thus eliminating the inhibition of Runx2. Runx2 serves as a transcriptional activator that binds to the Bglap2 promoter and increases osteocalcin expression, which favors glucose metabolism.
Molecular model of Foxo1 and IGF1/insulin regulation of osteocalcin expression
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Publication

Foxo1 Mediates Insulin-like Growth Factor 1 (IGF1)/Insulin Regulation of Osteocalcin Expression by Antagonizing Runx2 in Osteoblasts. (2011) Shengyong Yang, et al. J Biol Chem. 2011 May 27;286(21):19149-19158. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Insulin,IGF1 IGF1 ncbigene_symbol IGF1 3479
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates Foxo1-P FOXO1 ncbigene_symbol FOXO1 2308
Homo sapiens Primates 14-3-3 14-3-3 ncbigene_synonym YWHAQ 10971
Homo sapiens Primates Runx2 RUNX2 ncbigene_symbol RUNX2 860
Homo sapiens Primates Ocn OCN ncbigene_synonym BGLAP 632
Mus musculus Rodents Insulin,IGF1 IGF1 ncbigene_symbol Igf1 16000
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents PTEN PTEN ncbigene_symbol Pten 19211
Mus musculus Rodents Foxo1-P FOXO1 ncbigene_symbol Foxo1 56458
Mus musculus Rodents 14-3-3 14-3-3 ncbigene_synonym Sfn 55948
Mus musculus Rodents Runx2 RUNX2 ncbigene_symbol Runx2 12393
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates PTEN PTEN ncbigene_symbol Pten 43991
Drosophila melanogaster Invertebrates Foxo1-P FOXO1 ncbigene_synonym foxo 41709
Drosophila melanogaster Invertebrates 14-3-3 14-3-3 ncbigene_synonym 14-3-3zeta 36059
Drosophila melanogaster Invertebrates 14-3-3 14-3-3 ncbigene_synonym 14-3-3epsilon 42186
Drosophila melanogaster Invertebrates Ocn OCN ncbigene_symbol ocn 43567

Chemical mentions

Word Match MeSH Name ChEBI
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167

Disease mentions

Word Match MeSH Name DOID
Cancer NA