mTOR regulation pathway involved in hypoxia

mTOR regulation pathway involved in hypoxia. Everolimus combines with FKBP12, and obstructs the function of mTOR. p-mTOR (phosphorylated-mTOR) is inhibited by everolimus. Inhibition of mTOR increases the binding of 4E-BP1 to elF-4E, consequently leading to inactivation of HIF-1α mRNA translation. HIF-1 composed of α unit and β unit binds to hypoxia response elements (HREs), resulting in the upregulation of hypoxia-related factors such as VEGF (vascular endothelial growth factor), GLUT-1 (glucose transporter-1), and EPO (erythropoietin).
mTOR regulation pathway involved in hypoxia
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Publication

Analysis of mTOR Inhibition-Involved Pathway in Ovarian Clear Cell Adenocarcinoma. (2011) Makiko Harasawa, et al. Acta Histochem Cytochem. 2011 Apr 28;44(2):113-118. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents MTOR MTOR ncbigene_symbol Mtor 56717
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents HIF-la HIF1A ncbigene_symbol Hif1a 15251
Mus musculus Rodents 4E-BP1 4E-BP1 ncbigene_synonym Eif4ebp1 13685
Mus musculus Rodents EIF4E EIF4E ncbigene_symbol Eif4e 13684
Mus musculus Rodents FKBP12 FKBP12 ncbigene_synonym Fkbp1a 14225
Mus musculus Rodents HIF-1B HIF1B ncbigene_synonym Arnt 11863
Mus musculus Rodents VHL VHL ncbigene_symbol Vhl 22346
Mus musculus Rodents EPO EPO ncbigene_symbol Epo 13856
Mus musculus Rodents EPO EPO ncbigene_synonym Epx 13861
Mus musculus Rodents GLUT-1, GLUT-1 ncbigene_synonym Slc1a3 20512
Mus musculus Rodents GLUT-1, GLUT-1 ncbigene_synonym Slc2a1 20525
Mus musculus Rodents VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym Vegfa 22339
Rattus norvegicus Rodents MTOR MTOR ncbigene_symbol Mtor 56718
Rattus norvegicus Rodents Akt AKT ncbigene_synonym Akt1 24185
Rattus norvegicus Rodents HIF-la HIF1A ncbigene_symbol Hif1a 29560
Rattus norvegicus Rodents EIF4E EIF4E ncbigene_symbol Eif4e 117045
Rattus norvegicus Rodents FKBP12 FKBP12 ncbigene_synonym Fkbp1a 25639
Rattus norvegicus Rodents VHL VHL ncbigene_symbol Vhl 24874
Rattus norvegicus Rodents EPO EPO ncbigene_symbol Epo 24335
Rattus norvegicus Rodents GLUT-1, GLUT-1 ncbigene_synonym Slc1a3 29483
Rattus norvegicus Rodents VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym Vegfa 83785
Capra hircus Mammals MTOR MTOR ncbigene_symbol MTOR 100860902
Capra hircus Mammals HIF-la HIF1A ncbigene_symbol HIF1A 100861391
Capra hircus Mammals 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 100861234
Capra hircus Mammals EIF4E EIF4E ncbigene_symbol EIF4E 102184413
Capra hircus Mammals VHL VHL ncbigene_symbol VHL 102182921
Capra hircus Mammals EPO EPO ncbigene_symbol EPO 102180175
Capra hircus Mammals GLUT-1, GLUT1 ncbigene_synonym SLC2A1 102174800
Capra hircus Mammals VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym VEGFA 100860957
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates HIF-la HIF-1A ncbigene_synonym HIF1A 3091
Homo sapiens Primates 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 1978
Homo sapiens Primates EIF4E EIF4E ncbigene_symbol EIF4E 1977
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E2 9470
Homo sapiens Primates EIF4E EIF4E famplex_relations EIF4E3 317649
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1A 2280
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP1 2282
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP2 2283
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP3 2284
Homo sapiens Primates FKBP12 FKBP12 ncbigene_synonym FKBP1AP4 2285
Homo sapiens Primates HIF-1B HIF-1B ncbigene_synonym ARNT 405
Homo sapiens Primates VHL VHL ncbigene_symbol VHL 7428
Homo sapiens Primates HIF-1 HIF-1 ncbigene_synonym SETD2 29072
Homo sapiens Primates EPO EPO ncbigene_symbol EPO 2056
Homo sapiens Primates EPO EPO ncbigene_synonym TIMP1 7076
Homo sapiens Primates EPO EPO ncbigene_synonym EPX 8288
Homo sapiens Primates GLUT-1, GLUT-1 ncbigene_synonym SLC2A1 6513
Homo sapiens Primates VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym VEGFA 7422
Homo sapiens Primates VEGF,GLUT-1,EPOetc... VEGF famplex_relations VEGFB 7423
Homo sapiens Primates VEGF,GLUT-1,EPOetc... VEGF famplex_relations VEGFC 7424
Homo sapiens Primates VEGF,GLUT-1,EPOetc... VEGF famplex_relations VEGFD 2277
Homo sapiens Primates VEGF,GLUT-1,EPOetc... VEGF famplex_relations PGF 5228
Oryctolagus cuniculus Mammals MTOR MTOR ncbigene_symbol MTOR 100356164
Oryctolagus cuniculus Mammals HIF-la HIF-1A ncbigene_synonym HIF1A 100009579
Oryctolagus cuniculus Mammals EIF4E EIF4E ncbigene_symbol EIF4E 100009338
Oryctolagus cuniculus Mammals FKBP12 FKBP12 ncbigene_synonym FKBP1A 100328942
Oryctolagus cuniculus Mammals VHL VHL ncbigene_symbol VHL 100350053
Oryctolagus cuniculus Mammals EPO EPO ncbigene_symbol EPO 100008786
Oryctolagus cuniculus Mammals GLUT-1, GLUT1 ncbigene_synonym SLC2A1 100125988
Oryctolagus cuniculus Mammals VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym VEGFA 100008899
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates HIF-la HIF-1A ncbigene_synonym sima 43580
Drosophila melanogaster Invertebrates 4E-BP1 4E-BP1 ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E7 31059
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E4 38743
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E5 38878
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E3 38923
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E6 43422
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4E1 45525
Drosophila melanogaster Invertebrates EIF4E EIF4E ncbigene_synonym eIF4EHP 326255
Drosophila melanogaster Invertebrates FKBP12 FKBP12 ncbigene_symbol Fkbp12 37214
Drosophila melanogaster Invertebrates HIF-1B HIF-1B ncbigene_synonym tgo 41084
Drosophila melanogaster Invertebrates VHL VHL ncbigene_symbol Vhl 53433
Drosophila melanogaster Invertebrates GLUT-1, GLUT-1 ncbigene_synonym Glut1 38109
Drosophila melanogaster Invertebrates VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym Pvf1 32876
Drosophila melanogaster Invertebrates VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym Pvf2 33994
Drosophila melanogaster Invertebrates VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym Pvf3 33995
Drosophila melanogaster Invertebrates VEGF,GLUT-1,EPOetc... VEGF ncbigene_synonym Pvr 34127

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID