Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway

Summary of the cascades of events triggered by CsA. .CsA enhances TAK1 by activating TGFβ-dependent signaling . CsA also augments the expression of upstream kinases ZMP and AMPK in addition to IRAK. The enhancement in the expression/activity of these signaling proteins contributes to MAP kinase and NFkB activation, which together triggers proliferation, reduced apoptosis and enhanced angiogenesis.
Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway
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Procarcinogenic Effects of Cyclosporine A are Mediated through the Activation of TAK1/TAB1 Signaling Pathway. () Jianmin Xu, et al. Biochem Biophys Res Commun. ;408(3):363-368. Figure: F4.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates (TAK1) TAK1 ncbigene_synonym MAP3K7 6885
Homo sapiens Primates (TAK1) TAK1 ncbigene_synonym NR2C2 7182
Homo sapiens Primates TGFB TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGFB TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGFB TGFB famplex_relations TGFB3 7043
Homo sapiens Primates (TAB1 TAB1 ncbigene_symbol TAB1 10454
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates Ubcl UBCL ncbigene_synonym UBE2L1 283556
Homo sapiens Primates Ubcl UBC1 ncbigene_synonym UBE2K 3093
Homo sapiens Primates ECSIT ECSIT ncbigene_symbol ECSIT 51295
Homo sapiens Primates UEV1A UEV1A ncbigene_synonym UBE2V1 7335
Homo sapiens Primates ERK1 ERK1 ncbigene_synonym MAPK3 5595
Homo sapiens Primates ERK1/2 ERK2 ncbigene_synonym MAPK1 5594
Homo sapiens Primates ßt SST ncbigene_symbol SST 6750
Homo sapiens Primates IKKA/ßt IKKA ncbigene_synonym CHUK 1147
Homo sapiens Primates p65 P65 ncbigene_synonym RELA 5970
Homo sapiens Primates p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates p50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Homo sapiens Primates p-Hsp-27 HSP27 ncbigene_synonym HSPB1 3315
Homo sapiens Primates p-Hsp-27 HSP27 ncbigene_synonym HSPB2 3316
Homo sapiens Primates Bcl2 BCL2 ncbigene_symbol BCL2 596
Mus musculus Rodents (TAK1) TAK1 ncbigene_synonym Nr2c2 22026
Mus musculus Rodents (TAK1) TAK1 ncbigene_synonym Map3k7 26409
Mus musculus Rodents TGFB TGFB ncbigene_synonym Tgfb1 21803
Mus musculus Rodents TGFB TGFB ncbigene_synonym Ltbp1 268977
Mus musculus Rodents (TAB1 TAB1 ncbigene_symbol Tab1 66513
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents ECSIT ECSIT ncbigene_symbol Ecsit 26940
Mus musculus Rodents ERK1 ERK1 ncbigene_synonym Mapk3 26417
Mus musculus Rodents ERK1/2 ERK2 ncbigene_synonym Mapk1 26413
Mus musculus Rodents ßt SST ncbigene_symbol Sst 20604
Mus musculus Rodents ßt SST ncbigene_synonym Lmx1a 110648
Mus musculus Rodents IKKA/ßt IKKA ncbigene_synonym Chuk 12675
Mus musculus Rodents p65 P65 ncbigene_synonym Rela 19697
Mus musculus Rodents p65 P65 ncbigene_synonym Gorasp1 74498
Mus musculus Rodents p50 P50 ncbigene_synonym Cdc37 12539
Mus musculus Rodents p50 P50 ncbigene_synonym Lsp1 16985
Mus musculus Rodents p50 P50 ncbigene_synonym Nfkb1 18033
Mus musculus Rodents p50 P50 ncbigene_synonym Pold2 18972
Mus musculus Rodents p50 P50 ncbigene_synonym Cd40 21939
Mus musculus Rodents p50 P50 ncbigene_synonym Dctn2 69654
Mus musculus Rodents IKB IKB ncbigene_synonym Nfkbib 18036
Mus musculus Rodents p-Hsp-27 HSP27 ncbigene_synonym Hspb2 69253
Mus musculus Rodents Bcl2 BCL2 ncbigene_symbol Bcl2 12043
Bos taurus Mammals (TAB1 TAB1 ncbigene_symbol TAB1 519958
Bos taurus Mammals TRAF6 TRAF6 ncbigene_symbol TRAF6 539124
Bos taurus Mammals ECSIT ECSIT ncbigene_symbol ECSIT 507245
Bos taurus Mammals ERK1 ERK1 ncbigene_synonym MAPK3 531391
Bos taurus Mammals ERK1/2 ERK2 ncbigene_synonym MAPK1 327672
Bos taurus Mammals ßt SST ncbigene_symbol SST 280932
Bos taurus Mammals Bcl2 BCL2 ncbigene_symbol BCL2 281020
Drosophila melanogaster Invertebrates (TAK1) TAK1 ncbigene_symbol Tak1 39659
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym dpp 33432
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym gbb 37778
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates TGFB TGFB ncbigene_synonym mav 43804
Drosophila melanogaster Invertebrates TRAF6 TRAF6 ncbigene_symbol Traf6 31746
Drosophila melanogaster Invertebrates ECSIT ECSIT ncbigene_symbol ECSIT 40732
Drosophila melanogaster Invertebrates UEV1A UEV1A ncbigene_symbol Uev1A 38613
Drosophila melanogaster Invertebrates ERK1 ERK1 ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates ßt SST ncbigene_synonym MAGE 40860
Drosophila melanogaster Invertebrates p65 P65 ncbigene_synonym dl 35047
Drosophila melanogaster Invertebrates p65 P65 ncbigene_synonym wash 36311
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym Hrb27C 33968
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym betaTub60D 37888
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym Rpt5 42805
Drosophila melanogaster Invertebrates p50 P50 ncbigene_synonym DCTN2-p50 44086
Drosophila melanogaster Invertebrates p-Hsp-27 HSP-27 ncbigene_synonym Hsp27 39078
Drosophila melanogaster Invertebrates Bcl2 BCL2 ncbigene_synonym Debcl 53585

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID