Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells

IPA was performed for validated targets of miR-295 from this and prior studies , , , and identified the network, “Cell Death, Cell Cycle, Cellular Function and Maintenance,” which centers around p53. Solid lines indicate direct interactions and dashed lines indicate indirect interactions. Validated targets of miR-295 are shown in red and computationally predicted targets are shown in orange.
Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells
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Publication

A Latent Pro-Survival Function for the Mir-290-295 Cluster in Mouse Embryonic Stem Cells. (2011) Grace X. Y. Zheng, et al. PLoS Genet. 2011 May;7(5):e1002054. Figure: F6.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates GAS2 GAS2 ncbigene_symbol GAS2 2620
Homo sapiens Primates PTP4A3 PTP4A3 ncbigene_symbol PTP4A3 11156
Homo sapiens Primates CCNG1 CCNG1 ncbigene_symbol CCNG1 900
Homo sapiens Primates ERCC3 ERCC3 ncbigene_symbol ERCC3 2071
Homo sapiens Primates CASP2 CASP2 ncbigene_symbol CASP2 835
Homo sapiens Primates ZBTB17 ZBTB17 ncbigene_symbol ZBTB17 7709
Homo sapiens Primates SCMH1 SCMH1 ncbigene_symbol SCMH1 22955
Homo sapiens Primates CRADD CRADD ncbigene_symbol CRADD 8738
Homo sapiens Primates LATS2 LATS2 ncbigene_symbol LATS2 26524
Homo sapiens Primates CDK4/6-CyclinD1 CDK4 ncbigene_symbol CDK4 1019
Homo sapiens Primates LRDD LRDD ncbigene_synonym PIDD1 55367
Homo sapiens Primates BIRC6 BIRC6 ncbigene_symbol BIRC6 57448
Homo sapiens Primates CDKN2D CDKN2D ncbigene_symbol CDKN2D 1032
Homo sapiens Primates DDB2 DDB2 ncbigene_symbol DDB2 1643
Homo sapiens Primates Top2 TOP2 ncbigene_synonym TOP2A 7153
Homo sapiens Primates Top2 TOP2 famplex_relations TOP2B 7155
Homo sapiens Primates NDN NDN ncbigene_symbol NDN 4692
Homo sapiens Primates CDKN1A CDKN1A ncbigene_symbol CDKN1A 1026
Homo sapiens Primates CDKN1A CDKN1A ncbigene_synonym CDPF1 150383
Homo sapiens Primates RBL2 RBL2 ncbigene_symbol RBL2 5934
Homo sapiens Primates TGFBI TGFBI ncbigene_symbol TGFBI 7045
Homo sapiens Primates TP53 TP53 ncbigene_symbol TP53 7157
Homo sapiens Primates PRIM2 PRIM2 ncbigene_symbol PRIM2 5558
Homo sapiens Primates TBX2 TBX2 ncbigene_symbol TBX2 6909
Homo sapiens Primates CTCF CTCF ncbigene_symbol CTCF 10664
Homo sapiens Primates TP53INP1 TP53INP1 ncbigene_symbol TP53INP1 94241
Homo sapiens Primates CKS1B CKS1B ncbigene_symbol CKS1B 1163
Homo sapiens Primates BRF1 BRF1 ncbigene_symbol BRF1 2972
Homo sapiens Primates BRF1 BRF1 ncbigene_synonym ZFP36L1 677
Homo sapiens Primates BRF1 BRF1 ncbigene_synonym MST1L 11223
Homo sapiens Primates KDM2B KDM2B ncbigene_symbol KDM2B 84678
Homo sapiens Primates EI24 EI24 ncbigene_symbol EI24 9538
Homo sapiens Primates ZNF346 ZNF346 ncbigene_symbol ZNF346 23567
Homo sapiens Primates CLIC4 CLIC4 ncbigene_symbol CLIC4 25932
Homo sapiens Primates PEG3 PEG3 ncbigene_symbol PEG3 5178
Oryctolagus cuniculus Mammals GAS2 GAS2 ncbigene_symbol GAS2 100350627
Oryctolagus cuniculus Mammals PTP4A3 PTP4A3 ncbigene_symbol PTP4A3 100342107
Oryctolagus cuniculus Mammals CCNG1 CCNG1 ncbigene_symbol CCNG1 100357563
Oryctolagus cuniculus Mammals ERCC3 ERCC3 ncbigene_symbol ERCC3 100348395
Oryctolagus cuniculus Mammals CASP2 CASP2 ncbigene_symbol CASP2 100101590
Oryctolagus cuniculus Mammals ZBTB17 ZBTB17 ncbigene_symbol ZBTB17 100348036
Oryctolagus cuniculus Mammals SCMH1 SCMH1 ncbigene_symbol SCMH1 100358694
Oryctolagus cuniculus Mammals CRADD CRADD ncbigene_symbol CRADD 100354517
Oryctolagus cuniculus Mammals LATS2 LATS2 ncbigene_symbol LATS2 100356876
Oryctolagus cuniculus Mammals CDK4/6-CyclinD1 CDK4 ncbigene_symbol CDK4 100009039
Oryctolagus cuniculus Mammals BIRC6 BIRC6 ncbigene_symbol BIRC6 100342432
Oryctolagus cuniculus Mammals CDKN2D CDKN2D ncbigene_symbol CDKN2D 100349461
Oryctolagus cuniculus Mammals DDB2 DDB2 ncbigene_symbol DDB2 100352386
Oryctolagus cuniculus Mammals NDN NDN ncbigene_symbol NDN 100342225
Oryctolagus cuniculus Mammals CDKN1A CDKN1A ncbigene_symbol CDKN1A 100348489
Oryctolagus cuniculus Mammals RBL2 RBL2 ncbigene_symbol RBL2 100339977
Oryctolagus cuniculus Mammals TGFBI TGFBI ncbigene_symbol TGFBI 100009230
Oryctolagus cuniculus Mammals TP53 TP53 ncbigene_symbol TP53 100009292
Oryctolagus cuniculus Mammals PRIM2 PRIM2 ncbigene_symbol PRIM2 100347242
Oryctolagus cuniculus Mammals TBX2 TBX2 ncbigene_symbol TBX2 100359075
Oryctolagus cuniculus Mammals CTCF CTCF ncbigene_symbol CTCF 100350641
Oryctolagus cuniculus Mammals TP53INP1 TP53INP1 ncbigene_symbol TP53INP1 100358157
Oryctolagus cuniculus Mammals CKS1B CKS1B ncbigene_symbol CKS1B 100346466
Oryctolagus cuniculus Mammals BRF1 BRF1 ncbigene_symbol BRF1 100350146
Oryctolagus cuniculus Mammals KDM2B KDM2B ncbigene_symbol KDM2B 127482665
Oryctolagus cuniculus Mammals EI24 EI24 ncbigene_symbol EI24 100351308
Oryctolagus cuniculus Mammals ZNF346 ZNF346 ncbigene_symbol ZNF346 100355025
Oryctolagus cuniculus Mammals CLIC4 CLIC4 ncbigene_symbol CLIC4 100355635
Oryctolagus cuniculus Mammals PEG3 PEG3 ncbigene_symbol PEG3 100341995
Mus musculus Rodents GAS2 GAS2 ncbigene_symbol Gas2 14453
Mus musculus Rodents PTP4A3 PTP4A3 ncbigene_symbol Ptp4a3 19245
Mus musculus Rodents CCNG1 CCNG1 ncbigene_symbol Ccng1 12450
Mus musculus Rodents ERCC3 ERCC3 ncbigene_symbol Ercc3 13872
Mus musculus Rodents CASP2 CASP2 ncbigene_symbol Casp2 12366
Mus musculus Rodents ZBTB17 ZBTB17 ncbigene_symbol Zbtb17 22642
Mus musculus Rodents SCMH1 SCMH1 ncbigene_symbol Scmh1 29871
Mus musculus Rodents CRADD CRADD ncbigene_symbol Cradd 12905
Mus musculus Rodents LATS2 LATS2 ncbigene_symbol Lats2 50523
Mus musculus Rodents CDK4/6-CyclinD1 CDK4 ncbigene_symbol Cdk4 12567
Mus musculus Rodents LRDD LRDD ncbigene_synonym Pidd1 57913
Mus musculus Rodents BIRC6 BIRC6 ncbigene_symbol Birc6 12211
Mus musculus Rodents CDKN2D CDKN2D ncbigene_symbol Cdkn2d 12581
Mus musculus Rodents DDB2 DDB2 ncbigene_symbol Ddb2 107986
Mus musculus Rodents Top2 TOP2 ncbigene_synonym Top2a 21973
Mus musculus Rodents Top2 TOP2 ncbigene_synonym Top2b 21974
Mus musculus Rodents NDN NDN ncbigene_symbol Ndn 17984
Mus musculus Rodents CDKN1A CDKN1A ncbigene_symbol Cdkn1a 12575
Mus musculus Rodents RBL2 RBL2 ncbigene_symbol Rbl2 19651
Mus musculus Rodents TGFBI TGFBI ncbigene_symbol Tgfbi 21810
Mus musculus Rodents TP53 TP53 ncbigene_synonym Trp53 22059
Mus musculus Rodents PRIM2 PRIM2 ncbigene_symbol Prim2 19076
Mus musculus Rodents TBX2 TBX2 ncbigene_symbol Tbx2 21385
Mus musculus Rodents CTCF CTCF ncbigene_symbol Ctcf 13018
Mus musculus Rodents TP53INP1 TP53INP1 ncbigene_synonym Trp53inp1 60599
Mus musculus Rodents CKS1B CKS1B ncbigene_symbol Cks1b 54124
Mus musculus Rodents BRF1 BRF1 ncbigene_symbol Brf1 72308
Mus musculus Rodents BRF1 BRF1 ncbigene_synonym Zfp36l1 12192
Mus musculus Rodents CDC2B CDC2B ncbigene_symbol Cdc2b 107833
Mus musculus Rodents KDM2B KDM2B ncbigene_symbol Kdm2b 30841
Mus musculus Rodents EI24 EI24 ncbigene_symbol Ei24 13663
Mus musculus Rodents ZNF346 ZNF346 ncbigene_synonym Zfp346 26919
Mus musculus Rodents SERPINA3K SERPINA3K ncbigene_symbol Serpina3k 20714
Mus musculus Rodents CLIC4 CLIC4 ncbigene_symbol Clic4 29876
Mus musculus Rodents PEG3 PEG3 ncbigene_symbol Peg3 18616
Mus musculus Rodents PEG3 PEG3 ncbigene_synonym Aggf1 66549
Rattus norvegicus Rodents GAS2 GAS2 ncbigene_symbol Gas2 499156
Rattus norvegicus Rodents GAS2 GAS2 ncbigene_synonym Gas2l2 287570
Rattus norvegicus Rodents PTP4A3 PTP4A3 ncbigene_symbol Ptp4a3 362930
Rattus norvegicus Rodents CCNG1 CCNG1 ncbigene_symbol Ccng1 25405
Rattus norvegicus Rodents ERCC3 ERCC3 ncbigene_symbol Ercc3 291703
Rattus norvegicus Rodents CASP2 CASP2 ncbigene_symbol Casp2 64314
Rattus norvegicus Rodents ZBTB17 ZBTB17 ncbigene_symbol Zbtb17 313666
Rattus norvegicus Rodents SCMH1 SCMH1 ncbigene_symbol Scmh1 362581
Rattus norvegicus Rodents CRADD CRADD ncbigene_symbol Cradd 314756
Rattus norvegicus Rodents LATS2 LATS2 ncbigene_symbol Lats2 305922
Rattus norvegicus Rodents CDK4/6-CyclinD1 CDK4 ncbigene_symbol Cdk4 94201
Rattus norvegicus Rodents CDK4/6-CyclinD1 CDK4 ncbigene_synonym Defb1 83687
Rattus norvegicus Rodents LRDD LRDD ncbigene_synonym Pidd1 293625
Rattus norvegicus Rodents BIRC6 BIRC6 ncbigene_symbol Birc6 313876
Rattus norvegicus Rodents CDKN2D CDKN2D ncbigene_symbol Cdkn2d 494444
Rattus norvegicus Rodents DDB2 DDB2 ncbigene_symbol Ddb2 100362121
Rattus norvegicus Rodents NDN NDN ncbigene_symbol Ndn 308690
Rattus norvegicus Rodents CDKN1A CDKN1A ncbigene_symbol Cdkn1a 114851
Rattus norvegicus Rodents RBL2 RBL2 ncbigene_symbol Rbl2 81758
Rattus norvegicus Rodents TGFBI TGFBI ncbigene_symbol Tgfbi 116487
Rattus norvegicus Rodents TP53 TP53 ncbigene_symbol Tp53 24842
Rattus norvegicus Rodents PRIM2 PRIM2 ncbigene_symbol Prim2 301323
Rattus norvegicus Rodents TBX2 TBX2 ncbigene_symbol Tbx2 303398
Rattus norvegicus Rodents CTCF CTCF ncbigene_symbol Ctcf 83726
Rattus norvegicus Rodents TP53INP1 TP53INP1 ncbigene_symbol Tp53inp1 297822
Rattus norvegicus Rodents CKS1B CKS1B ncbigene_symbol Cks1b 499655
Rattus norvegicus Rodents BRF1 BRF1 ncbigene_symbol Brf1 299347
Rattus norvegicus Rodents BRF1 BRF1 ncbigene_synonym Zfp36l1 29344
Rattus norvegicus Rodents KDM2B KDM2B ncbigene_symbol Kdm2b 304495
Rattus norvegicus Rodents EI24 EI24 ncbigene_symbol Ei24 300514
Rattus norvegicus Rodents SERPINA3K SERPINA3K ncbigene_synonym Serpina3c 24794
Rattus norvegicus Rodents CLIC4 CLIC4 ncbigene_symbol Clic4 83718
Rattus norvegicus Rodents PEG3 PEG3 ncbigene_symbol Peg3 103691034
Rattus norvegicus Rodents PEG3 PEG3 ncbigene_synonym Ppp1r15a 171071
Drosophila melanogaster Invertebrates ERCC3 ERCC3 ncbigene_synonym hay 39202
Drosophila melanogaster Invertebrates CDK4/6-CyclinD1 CDK4 ncbigene_symbol Cdk4 36854
Drosophila melanogaster Invertebrates Top2 TOP2 ncbigene_symbol Top2 35225
Drosophila melanogaster Invertebrates PRIM2 PRIM2 ncbigene_symbol Prim2 44915
Drosophila melanogaster Invertebrates TBX2 TBX2 ncbigene_synonym bi 31379
Drosophila melanogaster Invertebrates CTCF CTCF ncbigene_symbol CTCF 38817
Drosophila melanogaster Invertebrates BRF1 BRF1 ncbigene_synonym Brf 42087
Caenorhabditis elegans Invertebrates CDK4/6-CyclinD1 CDK4 ncbigene_symbol cdk-4 181472
Caenorhabditis elegans Invertebrates Top2 TOP2 ncbigene_symbol top-2 174825
Caenorhabditis elegans Invertebrates TBX2 TBX2 ncbigene_symbol tbx-2 175698
Caenorhabditis elegans Invertebrates BRF1 BRF1 ncbigene_symbol brf-1 174199
Danio rerio Vertebrates GAS2 GAS2 ncbigene_symbol gas2 557312
Danio rerio Vertebrates GAS2 GAS2 ncbigene_synonym gas2b 567205
Danio rerio Vertebrates PTP4A3 PTP4A3 ncbigene_synonym ptp4a3a 406460
Danio rerio Vertebrates CCNG1 CCNG1 ncbigene_symbol ccng1 171473
Danio rerio Vertebrates ERCC3 ERCC3 ncbigene_symbol ercc3 324323
Danio rerio Vertebrates CASP2 CASP2 ncbigene_symbol casp2 373118
Danio rerio Vertebrates ZBTB17 ZBTB17 ncbigene_symbol zbtb17 564967
Danio rerio Vertebrates SCMH1 SCMH1 ncbigene_symbol scmh1 100037329
Danio rerio Vertebrates CRADD CRADD ncbigene_symbol cradd 450046
Danio rerio Vertebrates LATS2 LATS2 ncbigene_symbol lats2 567674
Danio rerio Vertebrates CDK4/6-CyclinD1 CDK4 ncbigene_symbol cdk4 777730
Danio rerio Vertebrates BIRC6 BIRC6 ncbigene_symbol birc6 796547
Danio rerio Vertebrates CDKN2D CDKN2D ncbigene_symbol cdkn2d 100333252
Danio rerio Vertebrates DDB2 DDB2 ncbigene_symbol ddb2 100004133
Danio rerio Vertebrates CDKN1A CDKN1A ncbigene_symbol cdkn1a 100151416
Danio rerio Vertebrates RBL2 RBL2 ncbigene_symbol rbl2 100331892
Danio rerio Vertebrates TGFBI TGFBI ncbigene_symbol tgfbi 321421
Danio rerio Vertebrates TP53 TP53 ncbigene_symbol tp53 30590
Danio rerio Vertebrates PRIM2 PRIM2 ncbigene_symbol prim2 407653
Danio rerio Vertebrates TBX2 TBX2 ncbigene_synonym tbx2b 30253
Danio rerio Vertebrates CTCF CTCF ncbigene_symbol ctcf 415104
Danio rerio Vertebrates TP53INP1 TP53INP1 ncbigene_symbol tp53inp1 568021
Danio rerio Vertebrates CKS1B CKS1B ncbigene_symbol cks1b 445199
Danio rerio Vertebrates BRF1 BRF1 ncbigene_synonym brf1a 334402
Danio rerio Vertebrates KDM2B KDM2B ncbigene_synonym kdm2bb 100536129
Danio rerio Vertebrates EI24 EI24 ncbigene_symbol ei24 550597
Danio rerio Vertebrates ZNF346 ZNF346 ncbigene_symbol znf346 560756
Danio rerio Vertebrates CLIC4 CLIC4 ncbigene_symbol clic4 368255
Danio rerio Vertebrates PEG3 PEG3 ncbigene_synonym znf271 793549

Chemical mentions

Word Match MeSH Name ChEBI
retinoic acid Tretinoin mesh:D014212 all-trans-retinoic acid chebi:15367

Disease mentions

Word Match MeSH Name DOID