Proteins encoding the CAF and tumor stroma-associated genes from seven different epithelial tumors share common involvement in the MAPK signaling pathway and focal adhesion

Proteins encoding the CAF and tumor stroma-associated genes from seven different epithelial tumors share common involvement in the MAPK signaling pathway and focal adhesion. CAF/tumor stroma characteristic gene signatures from seven studies were mapped to PPIs. In the resulting PPI network, 55 proteins interacting with multiple NSCLC stroma and CAF proteins identified in this study (NSCLC; top) and additional tumor stroma/CAF studies from breast cancer, cholangiocarcinoma (CCA), and basal cell carcinoma (BCC) show significant enrichment in focal adhesion and the MAPK pathway (P = 1.7 × 10−4 and P = 7.7 × 10−4, respectively). Shapes (nodes) represent proteins, and lines (edges) indicate physical PPIs, colored based on annotation to KEGG focal adhesion (hsa04510; yellow). PPI network was visualized with NAViGaTOR 2.1.14; indirectly linked proteins and interactions are faded-out to reduce image complexity.

Publication

Prognostic gene-expression signature of carcinoma-associated fibroblasts in non-small cell lung cancer. (2011) Roya Navab, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7160-7165. Figure: F4. All organisms Mus musculus Homo sapiens Danio rerio

Disease mentions