Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling

Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling. (a) The protein domain structures of Fas and TNFR-1. Each receptor has cysteine-rich domains (CRD) in the ligand binding region, characteristic of members of the TNF superfamily of receptors. There is a death domain in the intracellular portion of each receptor. (b) Fas death signaling patheways. (c) TNFR-1 signaling pathways. See text for details.
Mediators of the extrinsic pathway of PCD by Fas and TNFR-1 signaling
Download JPG
View figure at PMC Read paper at PMC Open at NDEx
PMC
NDEx

Publication

Programmed cell death and new discoveries in the genetics of parkinsonism. () Robert E. Burke. J Neurochem. ;104(4):875-890. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Fas FAS ncbigene_symbol FAS 355
Homo sapiens Primates Fas FAS ncbigene_synonym FASN 2194
Homo sapiens Primates TNFR-1 TNFR1 ncbigene_synonym TNFRSF1A 7132
Homo sapiens Primates CRD CRD ncbigene_synonym CRX 1406
Homo sapiens Primates CRD CRD ncbigene_synonym RPGR 6103
Homo sapiens Primates Fasl FASL ncbigene_synonym FASLG 356
Homo sapiens Primates TNF TNF ncbigene_symbol TNF 7124
Homo sapiens Primates TRADD TRADD ncbigene_symbol TRADD 8717
Homo sapiens Primates FADD FADD ncbigene_symbol FADD 8772
Homo sapiens Primates Daxx DAXX ncbigene_symbol DAXX 1616
Homo sapiens Primates ASK-1 ASK1 ncbigene_synonym MAP3K5 4217
Homo sapiens Primates Bid BID ncbigene_symbol BID 637
Homo sapiens Primates JNK JNK ncbigene_synonym MAPK8 5599
Homo sapiens Primates JNK JNK famplex_relations MAPK9 5601
Homo sapiens Primates JNK JNK famplex_relations MAPK10 5602

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID