Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing

Important genes involved in sia synthesis, activation, conjugation and breakdown are depicted in the boxes. Sialic acid synthesis starts in the cytosole and then sia is activated in the nucleus. Activated sia is transported to Golgi for conjugation and modification. These sialylated conjugates are cleaved by neuraminidases found in the lysosomes, cytosole and the cell membrane. The genes expressed in Holstein/Jersey milk are underlined. Among the expressed genes only ST8SIA1 (marked with an asterisk) had a higher expression in the transition milk. All other genes had higher expression in late lactation.
Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing
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Publication

Transcriptome Profiling of Bovine Milk Oligosaccharide Metabolism Genes Using RNA-Sequencing. (2011) Saumya Wickramasinghe, et al. PLoS One. 2011;6(4):e18895. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ST3GAL1 ST3GAL1 ncbigene_symbol ST3GAL1 6482
Homo sapiens Primates ST3GAL2 ST3GAL2 ncbigene_symbol ST3GAL2 6483
Homo sapiens Primates ST3GAL3 ST3GAL3 ncbigene_symbol ST3GAL3 6487
Homo sapiens Primates ST3GAL4 ST3GAL4 ncbigene_symbol ST3GAL4 6484
Homo sapiens Primates ST3GAL5 ST3GAL5 ncbigene_symbol ST3GAL5 8869
Homo sapiens Primates ST3GAL6 ST3GAL6 ncbigene_symbol ST3GAL6 10402
Homo sapiens Primates ST6GAL1 ST6GAL1 ncbigene_symbol ST6GAL1 6480
Homo sapiens Primates GNE GNE ncbigene_symbol GNE 10020
Homo sapiens Primates SLC35A1 SLC35A1 ncbigene_symbol SLC35A1 10559
Homo sapiens Primates ST6GAL2 ST6GAL2 ncbigene_symbol ST6GAL2 84620
Homo sapiens Primates ST6GALNAC1 ST6GALNAC1 ncbigene_symbol ST6GALNAC1 55808
Homo sapiens Primates ST6GALNAC2 ST6GALNAC2 ncbigene_symbol ST6GALNAC2 10610
Homo sapiens Primates ST6GALNAC5 ST6GALNAC5 ncbigene_symbol ST6GALNAC5 81849
Homo sapiens Primates CMAH CMAH ncbigene_synonym CMAHP 8418
Homo sapiens Primates ST6GALNAC6 ST6GALNAC6 ncbigene_symbol ST6GALNAC6 30815
Homo sapiens Primates ST8SIA1* ST8SIA1 ncbigene_symbol ST8SIA1 6489
Homo sapiens Primates NANS NANS ncbigene_symbol NANS 54187
Homo sapiens Primates Neu3 NEU3 ncbigene_symbol NEU3 10825
Homo sapiens Primates ST8SIA2 ST8SIA2 ncbigene_symbol ST8SIA2 8128
Homo sapiens Primates ST8SIA3 ST8SIA3 ncbigene_symbol ST8SIA3 51046
Homo sapiens Primates Neu4 NEU4 ncbigene_symbol NEU4 129807
Homo sapiens Primates ST8SIA4 ST8SIA4 ncbigene_symbol ST8SIA4 7903
Homo sapiens Primates ST8SIA5 ST8SIA5 ncbigene_symbol ST8SIA5 29906
Homo sapiens Primates ST8SIA6 ST8SIA6 ncbigene_symbol ST8SIA6 338596
Homo sapiens Primates NANP NANP ncbigene_symbol NANP 140838
Homo sapiens Primates Neu1 NEU1 ncbigene_symbol NEU1 4758
Homo sapiens Primates Neu1 NEU1 ncbigene_synonym NEURL1 9148
Homo sapiens Primates Neu1 NEU1 ncbigene_synonym EGFL7 51162
Homo sapiens Primates Neu2 NEU2 ncbigene_symbol NEU2 4759
Homo sapiens Primates CMAS CMAS ncbigene_symbol CMAS 55907
Homo sapiens Primates SLC17A5 SLC17A5 ncbigene_symbol SLC17A5 26503

Chemical mentions

Word Match MeSH Name ChEBI
ManNAc-6-P NA mesh:C430285
CMP-Neu5Ac NA mesh:C561601
UDP Uridine Diphosphate mesh:D014530 UDP chebi:17659

Disease mentions

Word Match MeSH Name DOID