NFKB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28

NF-κB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28. TNFR1, TLR4 and TCR/CD28 engagement trigger the K63-linked ubiquitination of RIP1, TRAF6 and MALT1, respectively. Each of these ubiquitinated signaling molecules are targeted for deubiquitination by either A20, CYLD, Cezanne or USP21, as indicated. MALT1 cleaves A20 to inactivate its function. CYLD also removes polyubiquitin chains from TAK1 in the TCR pathway.
NFKB signaling pathways downstream of TNFR1, TLR4 and TCR/CD28
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Publication

Deubiquitinases in the regulation of NF-κB signaling. (2011) Edward W Harhaj, et al. Cell Res. 2011 Jan;21(1):22-39. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Rattus norvegicus Rodents TNF-a TNF-A ncbigene_synonym Tnf 24835
Rattus norvegicus Rodents TLR4 TLR4 ncbigene_symbol Tlr4 29260
Rattus norvegicus Rodents CD28 CD28 ncbigene_symbol Cd28 25660
Rattus norvegicus Rodents TNFR1 TNFR1 ncbigene_synonym Tnfrsf1a 25625
Rattus norvegicus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 116551
Rattus norvegicus Rodents PI3K PI3K ncbigene_synonym Pik3cg 298947
Rattus norvegicus Rodents (Lck LCK ncbigene_symbol Lck 313050
Rattus norvegicus Rodents TRADD TRADD ncbigene_symbol Tradd 246756
Rattus norvegicus Rodents TRAF2 TRAF2 ncbigene_symbol Traf2 311786
Rattus norvegicus Rodents (MyD88 MYD88 ncbigene_symbol Myd88 301059
Rattus norvegicus Rodents IRAK4 IRAK4 ncbigene_symbol Irak4 300177
Rattus norvegicus Rodents ZAP-70 ZAP70 ncbigene_symbol Zap70 301348
Rattus norvegicus Rodents (IRAK1 IRAK1 ncbigene_symbol Irak1 363520
Rattus norvegicus Rodents Bcl10 BCL10 ncbigene_symbol Bcl10 83477
Rattus norvegicus Rodents MALT1 MALT1 ncbigene_symbol Malt1 307366
Rattus norvegicus Rodents (TRAF6 TRAF6 ncbigene_symbol Traf6 311245
Rattus norvegicus Rodents TAB1 TAB1 ncbigene_symbol Tab1 315139
Rattus norvegicus Rodents TAB2 TAB2 ncbigene_symbol Tab2 308267
Rattus norvegicus Rodents TAB2/3 TAB3 ncbigene_symbol Tab3 317546
Rattus norvegicus Rodents CYLD CYLD ncbigene_symbol Cyld 312937
Rattus norvegicus Rodents TAK1 TAK1 ncbigene_synonym Map3k7 313121
Rattus norvegicus Rodents (IKKA IKKA ncbigene_synonym Chuk 309361
Rattus norvegicus Rodents USP21 USP21 ncbigene_symbol Usp21 688466
Rattus norvegicus Rodents p65 P65 ncbigene_synonym Syt1 25716
Homo sapiens Primates TNF-a TNF-A ncbigene_synonym TNF 7124
Homo sapiens Primates LPS LPS ncbigene_synonym IRF6 3664
Homo sapiens Primates TCR TCR ncbigene_synonym TRBV20OR9-2 6962
Homo sapiens Primates TCR TCR famplex_relations TRA 6955
Homo sapiens Primates TCR TCR famplex_relations TRB 6957
Homo sapiens Primates TCR TCR famplex_relations TRD 6964
Homo sapiens Primates TCR TCR famplex_relations TRG 6965
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates CD28 CD28 ncbigene_symbol CD28 940
Homo sapiens Primates TNFR1 TNFR1 ncbigene_synonym TNFRSF1A 7132
Homo sapiens Primates Carma1 CARMA1 ncbigene_synonym CARD11 84433
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates (Lck LCK ncbigene_symbol LCK 3932
Homo sapiens Primates TRADD TRADD ncbigene_symbol TRADD 8717
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates CIAP1,2 CIAP2 ncbigene_synonym BIRC3 330
Homo sapiens Primates CIAP1,2 CIAP1 ncbigene_synonym BIRC2 329
Homo sapiens Primates (MyD88 MYD88 ncbigene_symbol MYD88 4615
Homo sapiens Primates IRAK4 IRAK4 ncbigene_symbol IRAK4 51135
Homo sapiens Primates PLC-) PLC ncbigene_synonym HSPG2 3339
Homo sapiens Primates PLC-) PLC famplex_relations PLCE1 51196
Homo sapiens Primates PLC-) PLC famplex_relations PLCZ1 89869
Homo sapiens Primates PLC-) PLC famplex_relations PLCB1 23236
Homo sapiens Primates PLC-) PLC famplex_relations PLCB2 5330
Homo sapiens Primates PLC-) PLC famplex_relations PLCB3 5331
Homo sapiens Primates PLC-) PLC famplex_relations PLCB4 5332
Homo sapiens Primates PLC-) PLC famplex_relations PLCD1 5333
Homo sapiens Primates PLC-) PLC famplex_relations PLCD3 113026
Homo sapiens Primates PLC-) PLC famplex_relations PLCD4 84812
Homo sapiens Primates PLC-) PLC famplex_relations PLCG1 5335
Homo sapiens Primates PLC-) PLC famplex_relations PLCG2 5336
Homo sapiens Primates ZAP-70 ZAP-70 ncbigene_synonym ZAP70 7535
Homo sapiens Primates (IRAK1 IRAK1 ncbigene_symbol IRAK1 3654
Homo sapiens Primates Bcl10 BCL10 ncbigene_symbol BCL10 8915
Homo sapiens Primates MALT1 MALT1 ncbigene_symbol MALT1 10892
Homo sapiens Primates (TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Homo sapiens Primates A20 A20 ncbigene_synonym TNFAIP3 7128
Homo sapiens Primates A20 A20 ncbigene_synonym IGKV1-27 28935
Homo sapiens Primates TAB1 TAB1 ncbigene_symbol TAB1 10454
Homo sapiens Primates TAB2 TAB2 ncbigene_symbol TAB2 23118
Homo sapiens Primates TAB2/3 TAB3 ncbigene_symbol TAB3 257397
Homo sapiens Primates CYLD CYLD ncbigene_symbol CYLD 1540
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym MAP3K7 6885
Homo sapiens Primates TAK1 TAK1 ncbigene_synonym NR2C2 7182
Homo sapiens Primates Cezanne CEZANNE ncbigene_synonym OTUD7B 56957
Homo sapiens Primates IKKY IKKG ncbigene_synonym IKBKG 8517
Homo sapiens Primates IKKB IKKB ncbigene_synonym IKBKB 3551
Homo sapiens Primates (IKKA IKKA ncbigene_synonym CHUK 1147
Homo sapiens Primates USP21 USP21 ncbigene_symbol USP21 27005
Homo sapiens Primates USP21 USP21 ncbigene_synonym USP25 29761
Homo sapiens Primates IKK@ IKK famplex_relations IKBKE 9641
Homo sapiens Primates IKK@ IKK famplex_relations TBK1 29110
Homo sapiens Primates IKBa IKBA ncbigene_synonym NFKBIA 4792
Homo sapiens Primates p65 P65 ncbigene_synonym RELA 5970
Homo sapiens Primates p65 P65 ncbigene_synonym SYT1 6857
Homo sapiens Primates p65 P65 ncbigene_synonym GORASP1 64689
Homo sapiens Primates p65 P65 ncbigene_synonym WNK1 65125
Homo sapiens Primates p50 P50 ncbigene_synonym CD40 958
Homo sapiens Primates p50 P50 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p50 P50 ncbigene_synonym ASCC1 51008
Homo sapiens Primates p50 P50 ncbigene_synonym H3P40 115482723
Mus musculus Rodents TNF-a TNF-A ncbigene_synonym Tnf 21926
Mus musculus Rodents LPS LPS ncbigene_synonym Tlr4 21898
Mus musculus Rodents TCR TCR ncbigene_synonym Trav6-3 328483
Mus musculus Rodents CD28 CD28 ncbigene_symbol Cd28 12487
Mus musculus Rodents TNFR1 TNFR1 ncbigene_synonym Tnfrsf1a 21937
Mus musculus Rodents TNFR1 TNFR1 ncbigene_synonym Tnfrsf1b 21938
Mus musculus Rodents Carma1 CARMA1 ncbigene_synonym Card11 108723
Mus musculus Rodents PDK1 PDK1 ncbigene_symbol Pdk1 228026
Mus musculus Rodents PDK1 PDK1 ncbigene_synonym Pdpk1 18607
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents (Lck LCK ncbigene_symbol Lck 16818
Mus musculus Rodents TRADD TRADD ncbigene_symbol Tradd 71609
Mus musculus Rodents TRAF2 TRAF2 ncbigene_symbol Traf2 22030
Mus musculus Rodents CIAP1,2 CIAP2 ncbigene_synonym Birc3 11796
Mus musculus Rodents CIAP1,2 CIAP2 ncbigene_synonym Birc2 11797
Mus musculus Rodents (MyD88 MYD88 ncbigene_symbol Myd88 17874
Mus musculus Rodents IRAK4 IRAK4 ncbigene_symbol Irak4 266632
Mus musculus Rodents PLC-) PLC ncbigene_synonym Hspg2 15530
Mus musculus Rodents PKCO PKC0 ncbigene_synonym Prkcq 18761
Mus musculus Rodents ZAP-70 ZAP-70 ncbigene_synonym Zap70 22637
Mus musculus Rodents (IRAK1 IRAK1 ncbigene_symbol Irak1 16179
Mus musculus Rodents Bcl10 BCL10 ncbigene_symbol Bcl10 12042
Mus musculus Rodents MALT1 MALT1 ncbigene_symbol Malt1 240354
Mus musculus Rodents (TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Mus musculus Rodents A20 A20 ncbigene_synonym Tnfaip3 21929
Mus musculus Rodents TAB1 TAB1 ncbigene_symbol Tab1 66513
Mus musculus Rodents TAB2 TAB2 ncbigene_symbol Tab2 68652
Mus musculus Rodents TAB2/3 TAB3 ncbigene_symbol Tab3 66724
Mus musculus Rodents CYLD CYLD ncbigene_symbol Cyld 74256
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Nr2c2 22026
Mus musculus Rodents TAK1 TAK1 ncbigene_synonym Map3k7 26409
Mus musculus Rodents Cezanne CEZANNE ncbigene_synonym Otud7b 229603
Mus musculus Rodents IKKB IKKB ncbigene_synonym Ikbkb 16150
Mus musculus Rodents (IKKA IKKA ncbigene_synonym Chuk 12675
Mus musculus Rodents USP21 USP21 ncbigene_symbol Usp21 30941
Mus musculus Rodents p65 P65 ncbigene_synonym Rela 19697
Mus musculus Rodents p65 P65 ncbigene_synonym Gorasp1 74498
Mus musculus Rodents p50 P50 ncbigene_synonym Cdc37 12539
Mus musculus Rodents p50 P50 ncbigene_synonym Lsp1 16985
Mus musculus Rodents p50 P50 ncbigene_synonym Nfkb1 18033
Mus musculus Rodents p50 P50 ncbigene_synonym Pold2 18972
Mus musculus Rodents p50 P50 ncbigene_synonym Cd40 21939
Mus musculus Rodents p50 P50 ncbigene_synonym Dctn2 69654
Danio rerio Vertebrates TNF-a TNF-A ncbigene_synonym tnfb 554167
Danio rerio Vertebrates CD28 CD28 ncbigene_symbol cd28 101886406
Danio rerio Vertebrates PDK1 PDK1 ncbigene_symbol pdk1 555840
Danio rerio Vertebrates (Lck LCK ncbigene_symbol lck 414333
Danio rerio Vertebrates TRADD TRADD ncbigene_symbol tradd 58130
Danio rerio Vertebrates (MyD88 MYD88 ncbigene_symbol myd88 403145
Danio rerio Vertebrates IRAK4 IRAK4 ncbigene_symbol irak4 393132
Danio rerio Vertebrates ZAP-70 ZAP70 ncbigene_symbol zap70 553615
Danio rerio Vertebrates (IRAK1 IRAK1 ncbigene_symbol irak1 569226
Danio rerio Vertebrates Bcl10 BCL10 ncbigene_symbol bcl10 100334750
Danio rerio Vertebrates MALT1 MALT1 ncbigene_symbol malt1 561914
Danio rerio Vertebrates MALT1 MALT1 ncbigene_synonym malt2 259196
Danio rerio Vertebrates (TRAF6 TRAF6 ncbigene_symbol traf6 554561
Danio rerio Vertebrates TAB1 TAB1 ncbigene_symbol tab1 403084
Danio rerio Vertebrates TAB2 TAB2 ncbigene_symbol tab2 494163
Danio rerio Vertebrates TAB2/3 TAB3 ncbigene_symbol tab3 566547
Danio rerio Vertebrates CYLD CYLD ncbigene_synonym cylda 556823
Danio rerio Vertebrates USP21 USP21 ncbigene_symbol usp21 563546
Danio rerio Vertebrates p65 P65 ncbigene_synonym rela 415099
Danio rerio Vertebrates p50 P50 ncbigene_synonym nfkb1 565756

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID