Schematic overview of the MDM2 and p53 signalling pathway

Schematic overview of the MDM2 and p53 signalling pathway

Schematic overview of the MDM2 and p53 signalling pathway. The induction of MDM2 leads to suppression of p53 by proteasomal degradation. The inhibition of the tumor suppressor gene p53 leads to suppression of the mitochondrial apoptotic pathway and to survival of the cells.

Publication

Rare Cause of Dysphagy: Giant Polypoid Esophageal Well-Differentiated Liposarcoma. (2007) Ladislav Mica, et al. Case Rep Gastroenterol. 2007;1(1):7-14. Figure: F6.

Gene mentions

Organism	Group	Word	Match	Source	NCBI Symbol	NCBI ID
Homo sapiens	Primates	Myc	MYC	ncbigene_symbol	MYC	4609
Homo sapiens	Primates	ARF	ARF	ncbigene_synonym	CDKN2A	1029
Homo sapiens	Primates	MDM-2	MDM2	ncbigene_symbol	MDM2	4193
Homo sapiens	Primates	p53	P53	ncbigene_synonym	TP53	7157
Homo sapiens	Primates	p53	P53	famplex_relations	TP63	8626
Homo sapiens	Primates	p53	P53	famplex_relations	TP73	7161
Homo sapiens	Primates	Bax	BAX	ncbigene_symbol	BAX	581
Homo sapiens	Primates	Bcl-2	BCL-2	ncbigene_synonym	BCL2	596
Drosophila melanogaster	Invertebrates	Myc	MYC	ncbigene_symbol	Myc	31310
Drosophila melanogaster	Invertebrates	ARF	ARF	ncbigene_synonym	Arl1	39745
Drosophila melanogaster	Invertebrates	ARF	ARF	ncbigene_synonym	Arf1	40506
Drosophila melanogaster	Invertebrates	ARF	ARF	ncbigene_synonym	Arl2	40993
Drosophila melanogaster	Invertebrates	p53	P53	ncbigene_symbol	p53	2768677
Drosophila melanogaster	Invertebrates	p53	P53	ncbigene_synonym	betaTub60D	37888
Drosophila melanogaster	Invertebrates	p53	P53	ncbigene_synonym	hth	41273
Drosophila melanogaster	Invertebrates	Bcl-2	BCL-2	ncbigene_synonym	Debcl	53585

Chemical mentions

Word	Match	MeSH	Name	ChEBI

Disease mentions

Word	Match	MeSH	Name	DOID