Top-scoring network created by Ingenuity Pathway Analysis

The top-scoring network created by Ingenuity Pathway Analysis. This network exhibited metastatic potential associated abundance changes for at least 27 of the 35 proteins in this network. Shaded genes are those identified in this study with color intensities representative of abundance changes in highly metastatic melanoma cells as follows: red ≥ 100-fold increase; shades of pink 2- to 100-fold increase; dark green ≥ 100-fold decrease; shades of green 2- to 100-fold decrease. The meaning of node shapes is defined in the insert. Some networks include metabolites as indicated by the symbols legend. The orange outlines on pathway shapes highlight proteins (genes) previously implicated in cancer. The software and/or the proteomics data did not consistently distinguish between protein family members and therefore in a few cases proteins were highlighted if a closely homologous protein was identified in the 3-D analysis.

Publication

A systems biology analysis of metastatic melanoma using in-depth three-dimensional protein profiling. () Mee-Jung Han, et al. Proteomics. ;10(24):4450-4462. Figure: F3. All organisms Homo sapiens Mus musculus Danio rerio

Disease mentions