Endothelial growth factor receptor (EGFR) signaling pathway
The endothelial growth factor receptor (EGFR) signaling pathway
Publication
Molecularly Targeted Therapy for Metastatic Colon Cancer: Proven Treatments and Promising New Agents. (2011) Majed El Zouhairi, et al. Gastrointest Cancer Res. 2011 Jan-Feb;4(1):15-21. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | EGF | EGF | ncbigene_synonym | Egfr | 37455 |
| Drosophila melanogaster | Invertebrates | Grb2 | GRB2 | ncbigene_synonym | drk | 36497 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K21B | 33203 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K59F | 37733 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K68D | 39329 |
| Drosophila melanogaster | Invertebrates | PI3K | PI3K | ncbigene_synonym | Pi3K92E | 42446 |
| Drosophila melanogaster | Invertebrates | sos | SOS | ncbigene_symbol | Sos | 34790 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | Ras | RAS | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | AKT | AKT | ncbigene_symbol | Akt | 41957 |
| Drosophila melanogaster | Invertebrates | PKC | PKC | ncbigene_synonym | inaC | 36897 |
| Drosophila melanogaster | Invertebrates | PKC | PKC | ncbigene_synonym | Pkc98E | 43428 |
| Drosophila melanogaster | Invertebrates | PKC | PKC | ncbigene_synonym | aPKC | 47594 |
| Drosophila melanogaster | Invertebrates | PKC | PKC | ncbigene_synonym | Pkc53E | 48311 |
| Drosophila melanogaster | Invertebrates | JAK | JAK | ncbigene_synonym | hop | 32080 |
| Drosophila melanogaster | Invertebrates | JAK | JAK | ncbigene_synonym | bsk | 44801 |
| Drosophila melanogaster | Invertebrates | Raf | RAF | ncbigene_symbol | Raf | 31221 |
| Drosophila melanogaster | Invertebrates | MEK | MEK | ncbigene_synonym | Dsor1 | 31872 |
| Drosophila melanogaster | Invertebrates | MEK | MEK | ncbigene_synonym | Mtk | 36708 |
| Drosophila melanogaster | Invertebrates | NFKB | NFKB | ncbigene_synonym | Dif | 35045 |
| Drosophila melanogaster | Invertebrates | NFKB | NFKB | ncbigene_synonym | dl | 35047 |
| Drosophila melanogaster | Invertebrates | NFKB | NFKB | ncbigene_synonym | Rel | 41087 |
| Drosophila melanogaster | Invertebrates | (STAT | STAT | ncbigene_synonym | Stat92E | 42428 |
| Drosophila melanogaster | Invertebrates | (MTOR | MTOR | ncbigene_symbol | Mtor | 36264 |
| Drosophila melanogaster | Invertebrates | (MTOR | MTOR | ncbigene_synonym | Tor | 47396 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | Erk7 | 31877 |
| Drosophila melanogaster | Invertebrates | ERK | ERK | ncbigene_synonym | rl | 3354888 |
| Drosophila melanogaster | Invertebrates | Cycle | CYCLE | ncbigene_synonym | CycE | 34924 |
| Drosophila melanogaster | Invertebrates | Cycle | CYCLE | ncbigene_synonym | cyc | 40162 |
| Homo sapiens | Primates | EGF | EGF | ncbigene_symbol | EGF | 1950 |
| Homo sapiens | Primates | EGFR | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | Grb2 | GRB2 | ncbigene_symbol | GRB2 | 2885 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CA | 5290 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CB | 5291 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CD | 5293 |
| Homo sapiens | Primates | PI3K | PI3K | ncbigene_synonym | PIK3CG | 5294 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R3 | 8503 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R4 | 30849 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R5 | 23533 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R6 | 146850 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R1 | 5295 |
| Homo sapiens | Primates | PI3K | PI3K | famplex_relations | PIK3R2 | 5296 |
| Homo sapiens | Primates | sos | SOS | ncbigene_synonym | XYLT2 | 64132 |
| Homo sapiens | Primates | sos | SOS | famplex_relations | SOS1 | 6654 |
| Homo sapiens | Primates | sos | SOS | famplex_relations | SOS2 | 6655 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | Ras | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | AKT | AKT | ncbigene_synonym | AKT1 | 207 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT2 | 208 |
| Homo sapiens | Primates | AKT | AKT | famplex_relations | AKT3 | 10000 |
| Homo sapiens | Primates | PKC | PKC | ncbigene_synonym | PRRT2 | 112476 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCA | 5578 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCB | 5579 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCD | 5580 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCE | 5581 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCG | 5582 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCH | 5583 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCI | 5584 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCQ | 5588 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKCZ | 5590 |
| Homo sapiens | Primates | PKC | PKC | famplex_relations | PRKD3 | 23683 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK1 | 3716 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK2 | 3717 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | JAK3 | 3718 |
| Homo sapiens | Primates | JAK | JAK | famplex_relations | TYK2 | 7297 |
| Homo sapiens | Primates | Raf | RAF | ncbigene_synonym | ZHX2 | 22882 |
| Homo sapiens | Primates | Raf | RAF | famplex_relations | ARAF | 369 |
| Homo sapiens | Primates | Raf | RAF | famplex_relations | BRAF | 673 |
| Homo sapiens | Primates | Raf | RAF | famplex_relations | RAF1 | 5894 |
| Homo sapiens | Primates | MEK | MEK | ncbigene_synonym | MAP2K7 | 5609 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K1 | 5604 |
| Homo sapiens | Primates | MEK | MEK | famplex_relations | MAP2K2 | 5605 |
| Homo sapiens | Primates | NFKB | NFKB | ncbigene_synonym | NFKB1 | 4790 |
| Homo sapiens | Primates | NFKB | NFKB | famplex_relations | RELA | 5970 |
| Homo sapiens | Primates | NFKB | NFKB | famplex_relations | RELB | 5971 |
| Homo sapiens | Primates | NFKB | NFKB | famplex_relations | REL | 5966 |
| Homo sapiens | Primates | NFKB | NFKB | famplex_relations | NFKB2 | 4791 |
| Homo sapiens | Primates | (STAT | STAT | ncbigene_synonym | SOAT1 | 6646 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT1 | 6772 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT2 | 6773 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT3 | 6774 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT4 | 6775 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT6 | 6778 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT5A | 6776 |
| Homo sapiens | Primates | (STAT | STAT | famplex_relations | STAT5B | 6777 |
| Homo sapiens | Primates | (MTOR | MTOR | ncbigene_symbol | MTOR | 2475 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | EPHB2 | 2048 |
| Homo sapiens | Primates | ERK | ERK | ncbigene_synonym | MAPK1 | 5594 |
| Homo sapiens | Primates | ERK | ERK | famplex_relations | MAPK3 | 5595 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Tipifarnib | tipifarnib | mesh:C402769 | tipifarnib | chebi:141969 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA | |||
| Cardiomyopathy | NA | |||
| Lung cancer | NA | |||
| Noonan syndrome | NA |