The Fanconi Anemia and Breast Cancer Susceptibility Pathways

After DNA damage, the Ataxia Telangiectasia and Rad3-related kinase (ATR) activates FA core complex (FANCA/B/C/E/F/G/L/M). The FA core complex then functions as an E3 ubiquitin ligase and monoubiquitinates FANCD2 and FANCI. The Monoubiquitinated FANCD2/FANCI complex is then targeted to chromatin where it forms complex with additional FA proteins and other DNA repair proteins. The USP1 and UAF1 protein complex then deubiquitinates FANCD2/FANCI complex, allowing their release from chromatin. USP1 is also required for localization of FANCD2/FANCI into DNA repair foci.
The Fanconi Anemia and Breast Cancer Susceptibility Pathways
Download JPG
View figure at PMC Read paper at PMC
PMC

Publication

The Fanconi Anemia and Breast Cancer Susceptibility Pathways. () D. Alan, et al. N Engl J Med. ;362(20):1909-1919. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Mus musculus Rodents ATR ATR ncbigene_symbol Atr 245000
Mus musculus Rodents ATR ATR ncbigene_synonym Mmab 77697
Mus musculus Rodents FA FA ncbigene_symbol fa 14072
Mus musculus Rodents USP1 USP1 ncbigene_symbol Usp1 230484
Mus musculus Rodents UAF1 UAF1 ncbigene_synonym Wdr48 67561
Mus musculus Rodents deubiquitinatesFANCD2/FANCI FANCI ncbigene_symbol Fanci 208836
Mus musculus Rodents FANCD2 FANCD2 ncbigene_symbol Fancd2 211651
Mus musculus Rodents BRCA2) BRCA2 ncbigene_symbol Brca2 12190
Homo sapiens Primates ATR ATR ncbigene_symbol ATR 545
Homo sapiens Primates ATR ATR ncbigene_synonym ANTXR1 84168
Homo sapiens Primates ATR ATR ncbigene_synonym MMAB 326625
Homo sapiens Primates ATR ATR ncbigene_synonym SERPINA2 390502
Homo sapiens Primates USP1 USP1 ncbigene_symbol USP1 7398
Homo sapiens Primates UAF1 UAF1 ncbigene_synonym WDR48 57599
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-8 619465
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-10 100616101
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-9 100616102
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-21 100616103
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-18 100775105
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-25 100862683
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-24 100862684
Homo sapiens Primates protease PROTEASE ncbigene_synonym ERVK-19 105376906
Homo sapiens Primates deubiquitinatesFANCD2/FANCI FANCI ncbigene_symbol FANCI 55215
Homo sapiens Primates FANCD2 FANCD2 ncbigene_symbol FANCD2 2177
Homo sapiens Primates BRCA2) BRCA2 ncbigene_symbol BRCA2 675
Drosophila melanogaster Invertebrates E3 E3 ncbigene_symbol E3 5658048
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym mei-41 32608
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym put 41772
Drosophila melanogaster Invertebrates ATR ATR ncbigene_synonym RYa-R 43253
Drosophila melanogaster Invertebrates USP1 USP1 ncbigene_symbol Usp1 43462
Drosophila melanogaster Invertebrates deubiquitinatesFANCD2/FANCI FANCI ncbigene_symbol FANCI 35895
Drosophila melanogaster Invertebrates FANCD2 FANCD2 ncbigene_symbol Fancd2 2768674
Drosophila melanogaster Invertebrates BRCA2) BRCA2 ncbigene_symbol Brca2 37916
Drosophila melanogaster Invertebrates and AND ncbigene_synonym CkIIbeta 32132
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Andorra 32798
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Anp 43595
Drosophila melanogaster Invertebrates and AND ncbigene_synonym Acam 44913
Drosophila melanogaster Invertebrates forms FORM ncbigene_synonym form3 3346238
Danio rerio Vertebrates ATR ATR ncbigene_symbol atr 567770
Danio rerio Vertebrates USP1 USP1 ncbigene_symbol usp1 322007
Danio rerio Vertebrates deubiquitinatesFANCD2/FANCI FANCI ncbigene_symbol fanci 324185
Danio rerio Vertebrates FANCD2 FANCD2 ncbigene_symbol fancd2 394241
Danio rerio Vertebrates BRCA2) BRCA2 ncbigene_symbol brca2 566758

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID