An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy

Cell surface receptors (FGFR or EGFR) activate RAS/MAPK or PI3K signaling pathways through FGFR substrate 2 (FRS2) and culminate in the activation of CREB3L2, which in turn stimulates transcription of ATF5. ATF5 then antagonizes apoptosis by directly up-regulating expression of the anti-apoptotic factor MCL1. Commercially available pharmacological inhibitors of several components of the ATF5-mediated survival pathway are indicated in gray.
An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy
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Publication

An Activating Transcription Factor 5-Mediated Survival Pathway as a Target for Cancer Therapy. (2010) Zhi Sheng, et al. Oncotarget. 2010 Oct;1(6):457-460. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates FRS2 FRS2 ncbigene_symbol FRS2 10818
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates RAS RAS famplex_relations KRAS 3845
Homo sapiens Primates RAS RAS famplex_relations HRAS 3265
Homo sapiens Primates RAS RAS famplex_relations NRAS 4893
Homo sapiens Primates PAK1 PAK1 ncbigene_symbol PAK1 5058
Homo sapiens Primates PAK1 PAK1 ncbigene_synonym PKN1 5585
Homo sapiens Primates RAF RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates RAF RAF famplex_relations ARAF 369
Homo sapiens Primates RAF RAF famplex_relations BRAF 673
Homo sapiens Primates RAF RAF famplex_relations RAF1 5894
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates CREB3L2 CREB3L2 ncbigene_symbol CREB3L2 64764
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates ERK ERK ncbigene_synonym MAPK1 5594
Homo sapiens Primates ERK ERK famplex_relations MAPK3 5595
Homo sapiens Primates ATF5 ATF5 ncbigene_symbol ATF5 22809
Homo sapiens Primates MCL1 MCL1 ncbigene_symbol MCL1 4170

Chemical mentions

Word Match MeSH Name ChEBI
Manumycin A Manumycin A mesh:C054474 manumycin chebi:29623
LY294002 NA mesh:C085911
U0126H U0126 mesh:C113580 U 0126 chebi:90693
PD173074 PD173074 mesh:C115711 PD 173074 chebi:63448

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA