TGFB signaling pathway

The TGF-β signaling pathway. The TGF-β signaling pathway is activated by binding of TGF-β to a type II receptor, which facilitates the recruitment and phosphorylation of the type I receptor. This pTGF-βRI activates either SMAD2 or SMAD3 by phosphorylation. The phosphorylated SMAD2/3 forms a complex with SMAD4 and transports to the nucleus where it influences SMAD target gene transcription. SMAD7 can inhibit TGF-β signaling through inhibition of TGF-βRI phosphorylation.
TGFB signaling pathway
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Publication

Molecular Characteristics of Pancreatic Ductal Adenocarcinoma. (2011) Niki A. Ottenhof, et al. Patholog Res Int. 2011;2011:620601. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates TGFB TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGFB TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGFB TGFB famplex_relations TGFB3 7043
Homo sapiens Primates TGFØRII TGFR2 ncbigene_synonym TGFBR2 7048
Homo sapiens Primates SMAD7 SMAD7 ncbigene_symbol SMAD7 4092
Homo sapiens Primates SMAD2 SMAD2 ncbigene_symbol SMAD2 4087
Homo sapiens Primates SMAD2/3 SMAD3 ncbigene_symbol SMAD3 4088
Homo sapiens Primates SMAD4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates SMAD SMAD famplex_relations SMAD1 4086
Homo sapiens Primates SMAD SMAD famplex_relations SMAD5 4090
Homo sapiens Primates SMAD SMAD famplex_relations SMAD6 4091
Homo sapiens Primates SMAD SMAD famplex_relations SMAD9 4093
Mus musculus Rodents TGFB TGFB ncbigene_synonym Tgfb1 21803
Mus musculus Rodents TGFB TGFB ncbigene_synonym Ltbp1 268977
Mus musculus Rodents SMAD7 SMAD7 ncbigene_symbol Smad7 17131
Mus musculus Rodents SMAD2 SMAD2 ncbigene_symbol Smad2 17126
Mus musculus Rodents SMAD2/3 SMAD3 ncbigene_symbol Smad3 17127
Mus musculus Rodents SMAD4 SMAD4 ncbigene_symbol Smad4 17128

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID