Model showing the regulation of PPARA by metabolism and PAR bZip transcription factors

Model showing the regulation of PPARα by metabolism and PAR bZip transcription factors. (Left) Under normal diet conditions, the expression of ACOTs are under the control of circadian PAR bZip transcription factors. These transcription factors thus control the release of free FA from acyl-CoA thioesters, and the free FAs stimulate PPARα activity. The activated PPARα then stimulates transcription of Acot and Lpl, and in a feed-forward loop reinforces its own expression and activity. (Right) Under a fat-free diet, all free FAs are derived from the de novo synthesis pathway. Under these conditions, PPARα activity is not dependent on PAR bZip transcription factors.

Publication

Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor α (PPARα) activity. (2011) Frédéric Gachon, et al. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4794-4799. Figure: F5. All organisms Mus musculus Homo sapiens

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