Simplified cartoon of PRR signaling in epithelial cells showing only the canonical pathway of NFKB activation and some of the key receptors, adaptors, and kinases involved

Simplified cartoon of PRR signaling in epithelial cells showing only the canonical pathway of NF-κB activation and some of the key receptors, adaptors, and kinases involved. After stimulation of TLRs or NLRs by microbial products, the inhibitor of IkB is phosphorylated, leading to its degradation and the translocation of NF-κB into the nucleus where it activates the expression of cytokines and chemokines and other effectors.

Publication

Epithelial crosstalk at the microbiota–mucosal interface. (2011) Jerry M. Wells, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(Suppl 1):4607-4614. Figure: F1. All organisms Mus musculus Homo sapiens Danio rerio

Disease mentions