Negative regulation of the IMD pathway
Negative regulation of the IMD pathway. Basal negative regulators (green) prevent the constitutive activation of the IMD pathway. Inducible negative regulators (red) (PGRP-LF excepted) modulate the amplitude of the IMD response. The PVR/RAS MAPK may inhibit the IMD pathway by upregulating the expression of the PIRK negative regulator. Arrows: positive interaction; dashed arrows: indirect activation; red boxes: interactions taking place in the gut epithelium; ROS: reactive oxygen species; DAP-PGN: diaminopimelic acid peptidoglycan.
Publication
Negative regulation of immune responses on the fly. (2011) Kwang-Zin Lee, et al. EMBO J. 2011 Mar 16;30(6):988-990. Figure: F1.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | PGRP-SC | PGRP-SC | ncbigene_synonym | PGRP-SC1a | 35859 |
| Drosophila melanogaster | Invertebrates | PGRP-SC | PGRP-SC | ncbigene_synonym | PGRP-SC1b | 35861 |
| Drosophila melanogaster | Invertebrates | PGRP-SC | PGRP-SC | ncbigene_synonym | PGRP-SC2 | 35862 |
| Drosophila melanogaster | Invertebrates | PGRP-LB | PGRP-LB | ncbigene_symbol | PGRP-LB | 41379 |
| Drosophila melanogaster | Invertebrates | Keren | KEREN | ncbigene_synonym | Krn | 326198 |
| Drosophila melanogaster | Invertebrates | Spitz | SPITZ | ncbigene_synonym | spi | 35253 |
| Drosophila melanogaster | Invertebrates | Vein | VEIN | ncbigene_synonym | vn | 38657 |
| Drosophila melanogaster | Invertebrates | PVF1,2,3 | PVF2 | ncbigene_symbol | Pvf2 | 33994 |
| Drosophila melanogaster | Invertebrates | PVF1,2,3 | PVF3 | ncbigene_symbol | Pvf3 | 33995 |
| Drosophila melanogaster | Invertebrates | PVF1,2,3 | PVF1 | ncbigene_symbol | Pvf1 | 32876 |
| Drosophila melanogaster | Invertebrates | Red | RED | ncbigene_symbol | red | 41738 |
| Drosophila melanogaster | Invertebrates | Red | RED | ncbigene_synonym | trc | 40165 |
| Drosophila melanogaster | Invertebrates | PGRP-LF | PGRP-LF | ncbigene_symbol | PGRP-LF | 39064 |
| Drosophila melanogaster | Invertebrates | IMD | IMD | ncbigene_symbol | imd | 44339 |
| Drosophila melanogaster | Invertebrates | PVR | PVR | ncbigene_symbol | Pvr | 34127 |
| Drosophila melanogaster | Invertebrates | EGFR? | EGFR | ncbigene_symbol | Egfr | 37455 |
| Drosophila melanogaster | Invertebrates | PGRP-LC | PGRP-LC | ncbigene_symbol | PGRP-LC | 39063 |
| Drosophila melanogaster | Invertebrates | Blue | BLUE | ncbigene_synonym | Neurl4 | 39558 |
| Drosophila melanogaster | Invertebrates | PVR/Ras/MAPK | RAS | ncbigene_symbol | ras | 43873 |
| Drosophila melanogaster | Invertebrates | PVR/Ras/MAPK | RAS | ncbigene_synonym | Ras64B | 38494 |
| Drosophila melanogaster | Invertebrates | PVR/Ras/MAPK | RAS | ncbigene_synonym | Ras85D | 41140 |
| Drosophila melanogaster | Invertebrates | PVR/Ras/MAPK | MAPK | ncbigene_synonym | MKP-4 | 32963 |
| Drosophila melanogaster | Invertebrates | PVR/Ras/MAPK | MAPK | ncbigene_synonym | p38b | 34780 |
| Drosophila melanogaster | Invertebrates | PVR/Ras/MAPK | MAPK | ncbigene_synonym | rl | 3354888 |
| Drosophila melanogaster | Invertebrates | PIRK | PIRK | ncbigene_symbol | pirk | 37468 |
| Drosophila melanogaster | Invertebrates | FADD | FADD | ncbigene_symbol | Fadd | 42594 |
| Drosophila melanogaster | Invertebrates | DREDD | DREDD | ncbigene_symbol | Dredd | 31011 |
| Drosophila melanogaster | Invertebrates | DUSP36 | DUSP36 | ncbigene_synonym | scny | 38648 |
| Drosophila melanogaster | Invertebrates | Pole | POLE | ncbigene_synonym | PolE1 | 42758 |
| Drosophila melanogaster | Invertebrates | POSH | POSH | ncbigene_symbol | POSH | 36990 |
| Drosophila melanogaster | Invertebrates | TAB2 | TAB2 | ncbigene_symbol | Tab2 | 37216 |
| Drosophila melanogaster | Invertebrates | DIAP2 | DIAP2 | ncbigene_symbol | Diap2 | 36748 |
| Drosophila melanogaster | Invertebrates | TAK1 | TAK1 | ncbigene_symbol | Tak1 | 39659 |
| Drosophila melanogaster | Invertebrates | DSOR | DSOR | ncbigene_synonym | Dsor1 | 31872 |
| Drosophila melanogaster | Invertebrates | UEV1A | UEV1A | ncbigene_symbol | Uev1A | 38613 |
| Drosophila melanogaster | Invertebrates | KEY | KEY | ncbigene_symbol | key | 37967 |
| Drosophila melanogaster | Invertebrates | EFF | EFF | ncbigene_symbol | eff | 41785 |
| Drosophila melanogaster | Invertebrates | Caspar | CASPAR | ncbigene_synonym | casp | 36769 |
| Drosophila melanogaster | Invertebrates | C-Relish | RELISH | ncbigene_synonym | Rel | 41087 |
| Drosophila melanogaster | Invertebrates | CYLD | CYLD | ncbigene_symbol | CYLD | 34380 |
| Drosophila melanogaster | Invertebrates | Pointed | POINTED | ncbigene_synonym | pnt | 42757 |
| Drosophila melanogaster | Invertebrates | SLMB | SLMB | ncbigene_symbol | slmb | 42504 |
| Drosophila melanogaster | Invertebrates | SKPA/SLMB | SKPA | ncbigene_symbol | SkpA | 31016 |
| Drosophila melanogaster | Invertebrates | DCUL1 | DCUL1 | ncbigene_synonym | Cul1 | 35742 |
| Drosophila melanogaster | Invertebrates | AMP | AMP | ncbigene_synonym | Amph | 36383 |
| Drosophila melanogaster | Invertebrates | Caudal | CAUDAL | ncbigene_synonym | cad | 35341 |
| Homo sapiens | Primates | Red | RED | ncbigene_synonym | IK | 3550 |
| Homo sapiens | Primates | Red | RED | ncbigene_synonym | DYRK3 | 8444 |
| Homo sapiens | Primates | PVR | PVR | ncbigene_symbol | PVR | 5817 |
| Homo sapiens | Primates | EGFR? | EGFR | ncbigene_symbol | EGFR | 1956 |
| Homo sapiens | Primates | PVR/Ras/MAPK | RAS | famplex_relations | KRAS | 3845 |
| Homo sapiens | Primates | PVR/Ras/MAPK | RAS | famplex_relations | HRAS | 3265 |
| Homo sapiens | Primates | PVR/Ras/MAPK | RAS | famplex_relations | NRAS | 4893 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK1 | 5594 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK3 | 5595 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK11 | 5600 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK12 | 6300 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK13 | 5603 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK14 | 1432 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK8 | 5599 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK9 | 5601 |
| Homo sapiens | Primates | PVR/Ras/MAPK | MAPK | famplex_relations | MAPK10 | 5602 |
| Homo sapiens | Primates | FADD | FADD | ncbigene_symbol | FADD | 8772 |
| Homo sapiens | Primates | hole | HOLE | ncbigene_synonym | TMEM121 | 80757 |
| Homo sapiens | Primates | Pole | POLE | ncbigene_symbol | POLE | 5426 |
| Homo sapiens | Primates | POSH | POSH | ncbigene_synonym | SH3RF1 | 57630 |
| Homo sapiens | Primates | TAB2 | TAB2 | ncbigene_symbol | TAB2 | 23118 |
| Homo sapiens | Primates | TAK1 | TAK1 | ncbigene_synonym | MAP3K7 | 6885 |
| Homo sapiens | Primates | TAK1 | TAK1 | ncbigene_synonym | NR2C2 | 7182 |
| Homo sapiens | Primates | UEV1A | UEV1A | ncbigene_synonym | UBE2V1 | 7335 |
| Homo sapiens | Primates | CYLD | CYLD | ncbigene_symbol | CYLD | 1540 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | APRT | 353 |
| Homo sapiens | Primates | AMP | AMP | ncbigene_synonym | MFAP1 | 4236 |
| Homo sapiens | Primates | ISCS | ISCS | ncbigene_synonym | NFS1 | 9054 |
| Word | Match | MeSH | Name | ChEBI |
|---|
Disease mentions
| Word | Match | MeSH | Name | DOID |
|---|---|---|---|---|
| Cancer | NA |