Model of the RBP-ROH/STRA6/JAK/STAT pathway

Model of the RBP-ROH/STRA6/JAK/STAT pathway. Binding of RBP-ROH to the extracellular moiety of STRA6 triggers tyrosine phosphorylation within an SH2 domain-binding motif in the receptor's cytosolic domain. Phosphorylated STRA6 recruits and activates JAK2, which, in turn, phosphorylates STAT5. Activated STAT5 translocates to the nucleus to regulate the expression of target genes, including SOCS3, which inhibits insulin signaling, and PPARĪ³, which enhances lipid accumulation. The model of STRA6 (GeneID 64220RBP) was generated using software http://bp.nuap.nagoya-u.ac.jp/sosui. The 3D structure of holo-RBP (GenBank accession no. DAA14765.1) was solved as described in ref. .
Model of the RBP-ROH/STRA6/JAK/STAT pathway
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Publication

Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. (2011) Daniel C. Berry, et al. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4340-4345. Figure: F5.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates STRA6 STRA6 ncbigene_symbol STRA6 64220
Homo sapiens Primates JAK2 JAK2 ncbigene_symbol JAK2 3717
Homo sapiens Primates SocS3 SOCS3 ncbigene_symbol SOCS3 9021
Homo sapiens Primates AKT AKT ncbigene_synonym AKT1 207
Homo sapiens Primates AKT AKT famplex_relations AKT2 208
Homo sapiens Primates AKT AKT famplex_relations AKT3 10000
Homo sapiens Primates GluT4 GLUT4 ncbigene_synonym SLC2A4 6517
Homo sapiens Primates STAT5 STAT5 ncbigene_synonym STAT5A 6776
Homo sapiens Primates STAT5 STAT5 ncbigene_synonym STAT5B 6777
Mus musculus Rodents STRA6 STRA6 ncbigene_symbol Stra6 20897
Mus musculus Rodents JAK2 JAK2 ncbigene_symbol Jak2 16452
Mus musculus Rodents SocS3 SOCS3 ncbigene_symbol Socs3 12702
Mus musculus Rodents AKT AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents GluT4 GLUT4 ncbigene_synonym Slc2a4 20528
Mus musculus Rodents STAT5 STAT5 ncbigene_synonym Stat5a 20850

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID