Antiviral apoptotic pathway is mediated by IRF-3 and Bax

Antiviral apoptotic pathway is mediated by IRF-3 and Bax. Many innate immune signaling pathways cause activation of IRF-3 as a transcription factor. Cytoplasmic dsRNA signals through RIG-I and IPS-1 to trigger both transcriptional and apoptotic antiviral pathways. For apoptosis, IRF-3 binds to Bax, activates it and translocates it to mitochondria, which cause cytochrome c release to the cytoplasm followed by caspase activation and apoptosis. Both pathways contribute to the antiviral state. Viruses employ many evasion strategies to block various steps of these pathways.
Antiviral apoptotic pathway is mediated by IRF-3 and Bax
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Publication

IRF-3 and Bax. () Saurabh Chattopadhyay, et al. Cell Cycle. ;9(13):2479-2480. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Nod2 NOD2 ncbigene_symbol NOD2 64127
Homo sapiens Primates TRIF TRIF ncbigene_synonym TRIM69 140691
Homo sapiens Primates TRIF TRIF ncbigene_synonym TICAM1 148022
Homo sapiens Primates Pol POL ncbigene_synonym ERVW-4 100616496
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates RIG-I RIG-I ncbigene_synonym RIGI 23586
Homo sapiens Primates IPS-1 IPS-1 ncbigene_synonym ISYNA1 51477
Homo sapiens Primates IPS-1 IPS-1 ncbigene_synonym MAVS 57506
Homo sapiens Primates DAI DAI ncbigene_synonym ZBP1 81030
Homo sapiens Primates TRAF3 TRAF3 ncbigene_symbol TRAF3 7187
Homo sapiens Primates TBK1 TBK1 ncbigene_symbol TBK1 29110
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates Bax BAX ncbigene_symbol BAX 581
Homo sapiens Primates IRF-3 IRF3 ncbigene_symbol IRF3 3661
Homo sapiens Primates Caspase CASPASE famplex_relations CASP1 834
Homo sapiens Primates Caspase CASPASE famplex_relations CASP2 835
Homo sapiens Primates Caspase CASPASE famplex_relations CASP4 837
Homo sapiens Primates Caspase CASPASE famplex_relations CASP5 838
Homo sapiens Primates Caspase CASPASE famplex_relations CASP6 839
Homo sapiens Primates Caspase CASPASE famplex_relations CASP8 841
Homo sapiens Primates Caspase CASPASE famplex_relations CASP9 842
Homo sapiens Primates Caspase CASPASE famplex_relations CASP10 843
Homo sapiens Primates Caspase CASPASE famplex_relations CASP12 100506742
Homo sapiens Primates Caspase CASPASE famplex_relations CASP14 23581
Homo sapiens Primates Caspase CASPASE famplex_relations CASP3 836
Homo sapiens Primates Caspase CASPASE famplex_relations CASP7 840
Homo sapiens Primates An AN ncbigene_symbol AN 100187761
Homo sapiens Primates TLR4 TLR4 ncbigene_symbol TLR4 7099
Homo sapiens Primates TLR3 TLR3 ncbigene_symbol TLR3 7098
Homo sapiens Primates TRAF2 TRAF2 ncbigene_symbol TRAF2 7186
Homo sapiens Primates TRAF2 TRAF2 ncbigene_synonym TANK 10010
Homo sapiens Primates TRAF6 TRAF6 ncbigene_symbol TRAF6 7189
Mus musculus Rodents Nod2 NOD2 ncbigene_symbol Nod2 257632
Mus musculus Rodents TRIF TRIF ncbigene_synonym Rnf138 56515
Mus musculus Rodents TRIF TRIF ncbigene_synonym Trim69 70928
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam1 106759
Mus musculus Rodents TRIF TRIF ncbigene_synonym Ticam2 225471
Mus musculus Rodents Pol POL ncbigene_synonym Mela 17276
Mus musculus Rodents Pol POL ncbigene_synonym Gm42368 105247234
Mus musculus Rodents PI3K PI3K ncbigene_synonym Pik3r1 18708
Mus musculus Rodents RIG-I RIG-I ncbigene_synonym Rigi 230073
Mus musculus Rodents IPS-1 IPS-1 ncbigene_synonym Mavs 228607
Mus musculus Rodents DAI DAI ncbigene_synonym Zbp1 58203
Mus musculus Rodents TRAF3 TRAF3 ncbigene_symbol Traf3 22031
Mus musculus Rodents TBK1 TBK1 ncbigene_symbol Tbk1 56480
Mus musculus Rodents Akt AKT ncbigene_synonym Akt1 11651
Mus musculus Rodents Bax BAX ncbigene_symbol Bax 12028
Mus musculus Rodents Bax BAX ncbigene_synonym Nkx3-1 18095
Mus musculus Rodents IRF-3 IRF-3 ncbigene_synonym Irf3 54131
Mus musculus Rodents TLR4 TLR4 ncbigene_symbol Tlr4 21898
Mus musculus Rodents TLR3 TLR3 ncbigene_symbol Tlr3 142980
Mus musculus Rodents TRAF2 TRAF2 ncbigene_symbol Traf2 22030
Mus musculus Rodents TRAF6 TRAF6 ncbigene_symbol Traf6 22034
Danio rerio Vertebrates Nod2 NOD2 ncbigene_symbol nod2 777696
Danio rerio Vertebrates TRIF TRIF ncbigene_synonym ticam1 403147
Danio rerio Vertebrates RIG-I RIG-I ncbigene_synonym rigi 100333797
Danio rerio Vertebrates TRAF3 TRAF3 ncbigene_symbol traf3 445119
Danio rerio Vertebrates TBK1 TBK1 ncbigene_symbol tbk1 692289
Danio rerio Vertebrates Bax BAX ncbigene_synonym baxa 58081
Danio rerio Vertebrates IRF-3 IRF3 ncbigene_symbol irf3 564854
Danio rerio Vertebrates TLR3 TLR3 ncbigene_symbol tlr3 403126
Danio rerio Vertebrates TRAF6 TRAF6 ncbigene_symbol traf6 554561

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID