Human Th17 differentiation: IL‐1 signaling appears to cooperate with a pathway driven by TGF‐B+ IL‐6/IL‐21/IL‐23 to induce human Th17 cells, associated with expression of ROR‐c and Stat3

Model of human Th17 differentiation: IL‐1 signaling appears to cooperate with a pathway driven by TGF‐β+ IL‐6/IL‐21/IL‐23 to induce human Th17 cells, associated with expression of ROR‐c and Stat3. IL‐23 might promote differentiation of human Th17 cells to a pathogenic phenotype, which contribute to autoimmune pathology. Human Th17 cells, depending on the stage of development, might lose Th17 phenotype or be redirected to Th1 cells by IFN‐γ/IL‐27/IL‐12, Th2 cells by IL‐4, or Tregs by IL‐2.
Human Th17 differentiation: IL‐1 signaling appears to cooperate with a pathway driven by TGF‐B+ IL‐6/IL‐21/IL‐23 to induce human Th17 cells, associated with expression of ROR‐c and Stat3
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Publication

Are Th17 Cells an Appropriate New Target in the Treatment of Rheumatoid Arthritis?. (2010) Hiroshi Kato, et al. Clin Transl Sci. 2010 Dec;3(6):319-326. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Danio rerio Vertebrates ROR-c RORC ncbigene_symbol rorc 100004847
Danio rerio Vertebrates ROR-c RORC ncbigene_synonym rorca 559245
Danio rerio Vertebrates Stat3 STAT3 ncbigene_symbol stat3 30767
Danio rerio Vertebrates IL-6 IL6 ncbigene_symbol il6 100885851
Danio rerio Vertebrates IL-21 IL21 ncbigene_symbol il21 100150203
Danio rerio Vertebrates IL-4 IL-4 ncbigene_synonym il13 794053
Danio rerio Vertebrates IL-4 IL-4 ncbigene_synonym il4 100188894
Danio rerio Vertebrates Th2 TH2 ncbigene_symbol th2 414844
Homo sapiens Primates IL-23 IL-23 ncbigene_synonym IL37 27178
Homo sapiens Primates IL-23 IL-23 ncbigene_synonym IL23A 51561
Homo sapiens Primates IL-1 IL-1 ncbigene_synonym IL1B 3553
Homo sapiens Primates ROR-c RORC ncbigene_symbol RORC 6097
Homo sapiens Primates Stat3 STAT3 ncbigene_symbol STAT3 6774
Homo sapiens Primates IL-6 IL-6 ncbigene_synonym IL6 3569
Homo sapiens Primates IL-21 IL-21 ncbigene_synonym IL22 50616
Homo sapiens Primates IL-21 IL-21 ncbigene_synonym IL21 59067
Homo sapiens Primates TGF-B TGFB ncbigene_synonym TGFB1 7040
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB2 7042
Homo sapiens Primates TGF-B TGFB famplex_relations TGFB3 7043
Homo sapiens Primates IL-27, IL-27 ncbigene_synonym IL27 246778
Homo sapiens Primates IL-12 IL12 famplex_relations IL12A 3592
Homo sapiens Primates IL-12 IL12 famplex_relations IL12B 3593
Homo sapiens Primates IL-2 IL-2 ncbigene_synonym IL2 3558
Homo sapiens Primates IL-4 IL-4 ncbigene_synonym IL4 3565
Homo sapiens Primates Th1 TH1 ncbigene_synonym NELFCD 51497

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID