Snail repressor is required for PMC ingression in the sea urchin embryo

Pmar1 de-repression system initiates the entire PMC specification program, and activates Alx1, Ets1 and other PMC regulatory genes (light blue oval), which in turn regulate skeletogenic differentiation genes (dark blue box). Alx1 regulates Snail (and other unknown EMT genes, denoted as X), and Snail represses Cadherin to attenuate the cell-cell adhesion, which allows PMCs to ingress into the blastocoele. Ets1 also regulates PMC ingression via unidentified EMT genes (denoted as Y). A subnetwork of EMT genes (light blue square box) regulates the EMT process of PMCs. The developmental stages shown on the left correspond to the chronological sequences of PMC developmental processes shown on the right.
Snail repressor is required for PMC ingression in the sea urchin embryo
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Publication

The Snail repressor is required for PMC ingression in the sea urchin embryo. () Shu-Yu Wu, et al. Development. ;134(6):1061-1070. Figure: F9.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates Alx1 ALX1 ncbigene_symbol ALX1 8092
Homo sapiens Primates (Hnf6, HNF6 ncbigene_synonym ONECUT1 3175
Homo sapiens Primates Ets1 ETS1 ncbigene_symbol ETS1 2113
Homo sapiens Primates HB HB ncbigene_synonym GSTM1 2944
Homo sapiens Primates EMT EMT ncbigene_synonym ITK 3702
Homo sapiens Primates EMT EMT ncbigene_synonym SLC22A3 6581
Homo sapiens Primates Snail SNAIL ncbigene_synonym SNAI1 6615
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH1 999
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH10 1008
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH11 1009
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH12 1010
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH13 1012
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH15 1013
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH16 1014
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH17 1015
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH18 1016
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH19 28513
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH2 1000
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH20 28316
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH22 64405
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH24 64403
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH3 1001
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH4 1002
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH5 1003
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH6 1004
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH7 1005
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH8 1006
Homo sapiens Primates Cadherin CADHERIN famplex_relations CDH9 1007
Homo sapiens Primates MB MB ncbigene_symbol MB 4151
Homo sapiens Primates P19 P19 ncbigene_synonym CDKN2A 1029
Homo sapiens Primates P19 P19 ncbigene_synonym CDKN2D 1032
Homo sapiens Primates P19 P19 ncbigene_synonym F9 2158
Homo sapiens Primates P19 P19 ncbigene_synonym REG1A 5967
Homo sapiens Primates P19 P19 ncbigene_synonym IL23A 51561
Homo sapiens Primates P19 P19 ncbigene_synonym H3P13 115482685
Drosophila melanogaster Invertebrates mic MIC ncbigene_synonym anon-92Ec 5657347
Drosophila melanogaster Invertebrates Rof ROF ncbigene_synonym norpA 31376
Drosophila melanogaster Invertebrates Tbr, TBR ncbigene_symbol tbr 252806
Drosophila melanogaster Invertebrates Dri) DRI ncbigene_synonym Pka-R1 40305
Drosophila melanogaster Invertebrates Dri) DRI ncbigene_synonym retn 45976
Drosophila melanogaster Invertebrates HB HB ncbigene_symbol hb 41032
Drosophila melanogaster Invertebrates Snail SNAIL ncbigene_synonym sna 34908
Drosophila melanogaster Invertebrates MB MB ncbigene_symbol mb 249737
Drosophila melanogaster Invertebrates MB MB ncbigene_synonym E(spl)mbeta-HLH 43152
Drosophila melanogaster Invertebrates P19 P19 ncbigene_synonym caz 32587
Drosophila melanogaster Invertebrates P19 P19 ncbigene_synonym l(1)20Ca 48279
Danio rerio Vertebrates Alx1 ALX1 ncbigene_symbol alx1 565176
Danio rerio Vertebrates Ets1 ETS1 ncbigene_symbol ets1 280651
Danio rerio Vertebrates Snail SNAI1 ncbigene_synonym snai1a 30273
Danio rerio Vertebrates MB MB ncbigene_symbol mb 393558
Danio rerio Vertebrates P19 P19 ncbigene_synonym nsg2 324971

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID