Major pathways of lipid metabolism in yeast

Major pathways of lipid metabolism in yeast. The pathways are color coded: (tan) glycerophospholipid pathway (violet) glycerol pathway, (yellow) phosphoinositides and inositol phosphates pathway, (blue) ceramide and sphingolipid pathway and (gray) sterol and TAG pathways. Solid arrows represent routes of metabolic conversion. Dotted lines represent multistep metabolic conversions. The names of structural genes (italicized) encoding enzymes catalyzing specific metabolic conversions are shown adjacent to arrows. An asterisk next to the gene name indicates genes regulated by inositol. Mutations in genes colored in green confer an overproduction of inositol (Opi−) phenotype due to elevated PA levels (). Mutations in genes colored in red confer an Ino− phenotype. An allele of the essential PIS1 gene (white letters on red background) has an Ino− phenotype. Genes enclosed in a rectangle are essential. Metabolites are indicated in plain text: DHAP dihydroxyacetone phosphate, DHA dihydroxyacetone, Gro-3-P glycerol 3-phosphate, G-6-P glucose 6-phosphate, I-3-P inositol 3-phosphate, lyso-PA lyso-phosphatidic acid, PA phosphatidic acid, DAG diacylglycerol, TAG triacylglycerol, CDP-DAG cytidine-diphosphate diacylglycerol, PS phosphatidylserine, PE phosphatidylethanolamine, SAM S-adenosyl methionine, PMME phosphatidyl-N-monomethylethanolamine, PDME phosphatidyl-N,N-dimethylethanolamine, PC phosphatidylcholine, Gro-PCho glycerophosphocholine, FFA free fatty acids, CDP-Cho cytidine-diphosphate-choline, Cho-P choline-phosphate, PI phosphatidylinositol, PI3P phosphatidylinositol 3-phosphate, PI4P phosphatidylinositol 4-phosphate, PI(3,5)P2, phosphatidylinositol 3,5-bisphosphate, PI(4,5)P2, phosphatidylinositol 4,5-bisphosphate, IP3 inositol 1,4,5-triphosphate, IP5 inositol 1,3,4,5,6-pentakisphosphate, IP6 inositol 1,2,3,4,5,6-hexakisphosphate, IP7 diphosphoinositol pentakisphosphate, IP8 bis-diphosphoinositol tetrakisphosphate, 3-KDHS 3-ketodihydrosphingosine, DHS dihydrosphingosine, PHS phytosphingosine, DHSP dihydrosphingosine 1-phosphate, PHSP phytosphingosine 1-phosphate, E-P ethanolamine-phosphate, α-HPhyto-Cer alpha-hydroxyphytoceramide, IPC inositol-phosphoceramide, MIPC mannose-inositol-phosphoceramide, M(IP)2C mannosyl-diinositol-phosphorylceramide

Publication

Genome-wide screen for inositol auxotrophy in Saccharomyces cerevisiae implicates lipid metabolism in stress response signaling. () Manuel J. Villa-García, et al. Mol Genet Genomics. ;285(2):125-149. Figure: F5. All organisms Saccharomyces cerevisiae S288C Homo sapiens

Disease mentions