Glycine synthesis and degradation
Glycine synthesis and degradation. The figure shows a schematic representation of glycine synthesis and degradation. SHMTs are the two serine hydroxymethyltransferase isoforms that catalyze the synthesis of glycine from serine, a reaction coupled with the conversion of tetrahydrofolate (THF) to 5,10-methylene THF. AMT, aminomethyltransferase; DLD, dihydrolipoamide dehydrogenase; GCSH, glycine cleavage system protein H and GLDC, glycine dehydrogenase, are components of the multiple-enzyme glycine cleavage system, the major pathway for glycine degradation.
Publication
Glycine and a Glycine Dehydrogenase (GLDC) SNP as Citalopram/Escitalopram Response Biomarkers in Depression: Pharmacometabolomics-informed Pharmacogenomics. () Yuan Ji, et al. Clin Pharmacol Ther. ;89(1):97-104. Figure: F3.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Homo sapiens | Primates | AMT | AMT | ncbigene_symbol | AMT | 275 |
| Homo sapiens | Primates | DLD | DLD | ncbigene_symbol | DLD | 1738 |
| Homo sapiens | Primates | DLD | DLD | ncbigene_synonym | FAM3A | 60343 |
| Homo sapiens | Primates | DLD | DLD | ncbigene_synonym | LDHD | 197257 |
| Homo sapiens | Primates | GCSH | GCSH | ncbigene_symbol | GCSH | 2653 |
| Homo sapiens | Primates | GLDC | GLDC | ncbigene_symbol | GLDC | 2731 |
| Danio rerio | Vertebrates | AMT | AMT | ncbigene_symbol | amt | 450000 |
| Danio rerio | Vertebrates | DLD | DLD | ncbigene_symbol | dld | 30138 |
| Danio rerio | Vertebrates | DLD | DLD | ncbigene_synonym | ldhd | 334208 |
| Danio rerio | Vertebrates | GLDC | GLDC | ncbigene_symbol | gldc | 321621 |
| Word | Match | MeSH | Name | ChEBI |
|---|---|---|---|---|
| Glycine | Glycine | mesh:D005998 | glycine | chebi:15428 |
| Serine | Serine | mesh:D012694 | L-serine | chebi:17115 |
Disease mentions
| Word | Match | MeSH | Name | DOID |
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