Anticoagulant properties of endothelial cells
Anticoagulant properties of endothelial cells. Heparan-sulphate (HS) is expressed on the endothelial surface and accelerates the interaction between antithrombin (AT) and its target enzymes, among which factor Xa and thrombin (IIa). Thrombomodulin (TM) and endothelial protein C receptor (EPCR) are also membrane proteins and are involved in protein C (PC) activation. Tissue factor pathway inhibitor (TFPI) and protein S (PS) are released into blood. TFPI, after combining with factor Xa, binds to and neutralizes the TF/VIIa complex on cell surfaces. Protein S is the cofactor of activated protein C (APC) which degrades factors Va and VIIIa. Micro-organisms and inflammatory mediators down-regulate the anticoagulant properties of the endothelium in different ways (see text).
Publication
Sepsis-Associated Disseminated Intravascular Coagulation and Thromboembolic Disease. (2010) Nicola Semeraro, et al. Mediterr J Hematol Infect Dis. 2010;2(3):e2010024. Figure: F2.| Organism | Group | Word | Match | Source | NCBI Symbol | NCBI ID |
|---|---|---|---|---|---|---|
| Drosophila melanogaster | Invertebrates | Va | VA | ncbigene_symbol | Va | 247258 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_symbol | Apc | 44642 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Apc2 | 42871 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Axn | 43565 |
| Drosophila melanogaster | Invertebrates | APC | APC | ncbigene_synonym | Fs(3)Apc | 49116 |
| Drosophila melanogaster | Invertebrates | PS | PS | ncbigene_symbol | ps | 44258 |
| Drosophila melanogaster | Invertebrates | TF | TF | ncbigene_symbol | tf | 252813 |
| Drosophila melanogaster | Invertebrates | dD | DD | ncbigene_symbol | Dd | 33107 |
| Drosophila melanogaster | Invertebrates | PC | PC | ncbigene_symbol | Pc | 40358 |
| Homo sapiens | Primates | Ila | ILA | ncbigene_synonym | TNFRSF9 | 3604 |
| Homo sapiens | Primates | APC | APC | ncbigene_symbol | APC | 324 |
| Homo sapiens | Primates | APC | APC | ncbigene_synonym | PROC | 5624 |
| Homo sapiens | Primates | TF | TF | ncbigene_symbol | TF | 7018 |
| Homo sapiens | Primates | TFPI | TFPI | ncbigene_symbol | TFPI | 7035 |
| Homo sapiens | Primates | PC | PC | ncbigene_symbol | PC | 5091 |
| Homo sapiens | Primates | EPCR | EPCR | ncbigene_synonym | PROCR | 10544 |
| Homo sapiens | Primates | TFP | TFP | ncbigene_synonym | TRIM39 | 56658 |
| Homo sapiens | Primates | TFP | TFP | ncbigene_synonym | INHCAP | 100129696 |
| Word | Match | MeSH | Name | ChEBI |
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Disease mentions
| Word | Match | MeSH | Name | DOID |
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