FBPA clustering on gene expression after direct irradiation

Pathway analysis of FBPA clustering on gene expression after direct irradiation. FBPA clusters 1 and 3 are shown here as networks generated by mapping genes using Agilent IDs and using the "grow" tool in IPA to identify potential transcriptional regulators upstream of genes in each cluster. Arrows indicate the direction of activity of a protein (empty node) interacting with the gene or gene product that is differentially expressed (colored node). Nodes are colored by log2 gene expression ratios in irradiated cells at 4 hours. On the scale bar, red indicates up-regulation and green, down-regulation of mRNA compared to sham-irradiated controls. Highlighted nodes indicate known transcriptional regulators involved in the radiation gene response in IMR-90 fibroblasts (violet outline) and potential new regulators of transcription (orange outline) suggested by the IPA analyses.
FBPA clustering on gene expression after direct irradiation
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Publication

Time-series clustering of gene expression in irradiated and bystander fibroblasts: an application of FBPA clustering. (2011) Shanaz A Ghandhi, et al. BMC Genomics. 2011;12:2-2. Figure: F7.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates ATF3 ATF3 ncbigene_symbol ATF3 467
Homo sapiens Primates LRDD LRDD ncbigene_synonym PIDD1 55367
Homo sapiens Primates ERG ERG ncbigene_symbol ERG 2078
Homo sapiens Primates SP100 SP100 ncbigene_symbol SP100 6672
Homo sapiens Primates KDM5B KDM5B ncbigene_symbol KDM5B 10765
Homo sapiens Primates HDAC2 HDAC2 ncbigene_symbol HDAC2 3066
Homo sapiens Primates CITED2 CITED2 ncbigene_symbol CITED2 10370
Homo sapiens Primates MYC MYC ncbigene_symbol MYC 4609
Homo sapiens Primates SMAD4 SMAD4 ncbigene_symbol SMAD4 4089
Homo sapiens Primates BTG3 BTG3 ncbigene_symbol BTG3 10950
Homo sapiens Primates DKK1 DKK1 ncbigene_symbol DKK1 22943
Homo sapiens Primates BATF3 BATF3 ncbigene_symbol BATF3 55509
Homo sapiens Primates FOXP) FOXP famplex_relations FOXP1 27086
Homo sapiens Primates FOXP) FOXP famplex_relations FOXP2 93986
Homo sapiens Primates FOXP) FOXP famplex_relations FOXP3 50943
Homo sapiens Primates FOXP) FOXP famplex_relations FOXP4 116113
Homo sapiens Primates TAF4B TAF4B ncbigene_symbol TAF4B 6875
Homo sapiens Primates TAF4B TAF4B ncbigene_synonym PAPPA-AS1 493913
Homo sapiens Primates E2F1 E2F1 ncbigene_symbol E2F1 1869
Homo sapiens Primates E2F1 E2F1 ncbigene_synonym UBE2L3 7332
Homo sapiens Primates TP73 TP73 ncbigene_symbol TP73 7161
Homo sapiens Primates PML PML ncbigene_symbol PML 5371
Homo sapiens Primates FOXO3 FOXO3 ncbigene_symbol FOXO3 2309
Homo sapiens Primates *MOM2 MOM2 ncbigene_synonym ATP5F1A 498
Homo sapiens Primates IRF3 IRF3 ncbigene_symbol IRF3 3661
Homo sapiens Primates NOTCH1 NOTCH1 ncbigene_symbol NOTCH1 4851
Homo sapiens Primates PERI PERI ncbigene_synonym PLIN1 5346
Homo sapiens Primates ETS2 ETS2 ncbigene_symbol ETS2 2114
Homo sapiens Primates ETS1 ETS1 ncbigene_symbol ETS1 2113
Homo sapiens Primates EPAS1 EPAS1 ncbigene_symbol EPAS1 2034
Homo sapiens Primates IRF1 IRF1 ncbigene_symbol IRF1 3659
Homo sapiens Primates JUN JUN ncbigene_symbol JUN 3725
Homo sapiens Primates JUN JUN famplex_relations JUNB 3726
Homo sapiens Primates JUN JUN famplex_relations JUND 3727
Homo sapiens Primates STAT STAT ncbigene_synonym SOAT1 6646
Homo sapiens Primates STAT STAT famplex_relations STAT1 6772
Homo sapiens Primates STAT STAT famplex_relations STAT2 6773
Homo sapiens Primates STAT STAT famplex_relations STAT3 6774
Homo sapiens Primates STAT STAT famplex_relations STAT4 6775
Homo sapiens Primates STAT STAT famplex_relations STAT6 6778
Homo sapiens Primates STAT STAT famplex_relations STAT5A 6776
Homo sapiens Primates STAT STAT famplex_relations STAT5B 6777
Homo sapiens Primates CAM CAM ncbigene_synonym CALM1 801
Homo sapiens Primates CAM CAM ncbigene_synonym CALM2 805
Homo sapiens Primates CAM CAM ncbigene_synonym CALM3 808
Homo sapiens Primates CAM CAM ncbigene_synonym KRIT1 889
Homo sapiens Primates CAM CAM ncbigene_synonym CAMKMT 79823
Homo sapiens Primates IRF2 IRF2 ncbigene_symbol IRF2 3660
Homo sapiens Primates DACH1 DACH1 ncbigene_symbol DACH1 1602
Homo sapiens Primates REL REL ncbigene_symbol REL 5966
Homo sapiens Primates COX2 COX2 ncbigene_symbol COX2 4513
Homo sapiens Primates COX2 COX2 ncbigene_synonym PTGS2 5743
Homo sapiens Primates COX2 COX2 ncbigene_synonym MTCO2P12 107075310
Homo sapiens Primates RELA RELA ncbigene_symbol RELA 5970
Homo sapiens Primates SERPINB2 SERPINB2 ncbigene_symbol SERPINB2 5055
Homo sapiens Primates NAB2 NAB2 ncbigene_symbol NAB2 4665
Homo sapiens Primates FOXL2 FOXL2 ncbigene_symbol FOXL2 668
Homo sapiens Primates EGR1 EGR1 ncbigene_symbol EGR1 1958
Homo sapiens Primates NFKBIZ NFKBIZ ncbigene_symbol NFKBIZ 64332
Homo sapiens Primates CEBPB CEBPB ncbigene_symbol CEBPB 1051
Homo sapiens Primates IL8 IL8 ncbigene_synonym CXCL8 3576
Homo sapiens Primates MEOX2 MEOX2 ncbigene_symbol MEOX2 4223
Homo sapiens Primates MAP10 MAP10 ncbigene_symbol MAP10 54627
Homo sapiens Primates CXCL3 CXCL3 ncbigene_symbol CXCL3 2921
Homo sapiens Primates RED RED ncbigene_synonym IK 3550
Homo sapiens Primates RED RED ncbigene_synonym DYRK3 8444
Homo sapiens Primates CXCL2 CXCL2 ncbigene_symbol CXCL2 2920
Homo sapiens Primates NFKBIE NFKBIE ncbigene_symbol NFKBIE 4794
Homo sapiens Primates BMP2 BMP2 ncbigene_symbol BMP2 650
Homo sapiens Primates ELF4 ELF4 ncbigene_symbol ELF4 2000
Homo sapiens Primates KLF2 KLF2 ncbigene_symbol KLF2 10365
Homo sapiens Primates RELB RELB ncbigene_symbol RELB 5971
Homo sapiens Primates AHR AHR ncbigene_symbol AHR 196
Homo sapiens Primates HOXAS HOXAS ncbigene_synonym HOTAIR 100124700
Homo sapiens Primates NKRF NKRF ncbigene_symbol NKRF 55922

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA