Outline of UDP-GlcNAc synthetic pathways

Outline of UDP-GlcNAc synthetic pathways. UDP-GlcNAc is synthesized by three glucose metabolic pathways, such as the pentose phosphate pathway and subsequent nucleotide synthesis, hexosamine biosynthetic pathway, and glycolysis, supplying UTP, glcosamine and acetyl group, respectively. GLUT, Glucose transporter; Glc, glucose; P, phosphate; R, ribose; CTP, cytidine triphosphate; GTP, guanosine triphosphate; UTP, uridine triphosphate; GnT, N-acetylglucosaminyltransferase; OGT, O-linked GnT; Fruc, fructose; GlcN, glucosamine; GlcNAc, N-acetylglucosamine; CoA, coenzyme A; ManNAc, N-acetylmannose; NeuAc, N-acetylneuraminic acid; G6PD, glucose-6-phosphate dyhydrogenase; GFAT, glutamine-Fruc-6-P amidotransferase; GNA, Glc-6-P N-acetyltransferase; UAP, UDP-GlcNAc pyrophosphorylase; PFK, phosphofructokinase; GNE, UDP-GlcNAc 2-epimerase/ManNAc kinase.
Outline of UDP-GlcNAc synthetic pathways
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Publication

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle. (2011) Ken Shirato, et al. J Clin Biochem Nutr. 2011 Jan;48(1):20-25. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates GLUT GLUT ncbigene_synonym SLC2A1 6513
Homo sapiens Primates Glc-1-P GLC1P ncbigene_symbol GLC1P 101448070
Homo sapiens Primates PFK PFK famplex_relations PFKL 5211
Homo sapiens Primates PFK PFK famplex_relations PFKM 5213
Homo sapiens Primates PFK PFK famplex_relations PFKP 5214
Homo sapiens Primates G6PD G6PD ncbigene_symbol G6PD 2539
Homo sapiens Primates G6PD G6PD ncbigene_synonym UBL4A 8266
Homo sapiens Primates GFAT GFAT ncbigene_synonym GFPT1 2673
Homo sapiens Primates GFAT GFAT ncbigene_synonym GFPT2 9945
Homo sapiens Primates CTP CTP ncbigene_synonym SLC25A1 6576
Homo sapiens Primates GTP GTP ncbigene_synonym MTG1 92170
Homo sapiens Primates UAP UAP ncbigene_synonym UBAP1 51271
Homo sapiens Primates GNE GNE ncbigene_symbol GNE 10020
Homo sapiens Primates OGT OGT ncbigene_symbol OGT 8473
Homo sapiens Primates OGT OGT famplex_relations EOGT 285203
Homo sapiens Primates OGT OGT famplex_relations POMGNT1 55624
Homo sapiens Primates OGT OGT famplex_relations POMGNT2 84892
Rattus norvegicus Rodents GLUT GLUT ncbigene_synonym Gls 24398
Rattus norvegicus Rodents G6PD G6PD ncbigene_symbol G6pd 24377
Rattus norvegicus Rodents GFAT GFAT ncbigene_synonym Gfpt1 297417
Rattus norvegicus Rodents CTP CTP ncbigene_synonym Slc25a1 29743
Rattus norvegicus Rodents CTP CTP ncbigene_synonym Pcyt1a 140544
Rattus norvegicus Rodents GTP GTP ncbigene_synonym Pck1 362282
Rattus norvegicus Rodents GNE GNE ncbigene_symbol Gne 114711
Rattus norvegicus Rodents OGT OGT ncbigene_symbol Ogt 26295
Mus musculus Rodents GLUT GLUT ncbigene_synonym Slc1a3 20512
Mus musculus Rodents Glc-1-P GLC-1 ncbigene_synonym Gmcl1 23885
Mus musculus Rodents G6PD G6PD ncbigene_synonym G6pdx 14381
Mus musculus Rodents GFAT GFAT ncbigene_synonym Gfpt1 14583
Mus musculus Rodents CTP CTP ncbigene_synonym Slc25a1 13358
Mus musculus Rodents COA COA ncbigene_synonym Hps3 12807
Mus musculus Rodents GNE GNE ncbigene_symbol Gne 50798
Mus musculus Rodents OGT OGT ncbigene_symbol Ogt 108155
Mus musculus Rodents GnT GNT ncbigene_synonym Gcnt7 654821
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Eaat1 34251
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut1 38109
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut4EF 41217
Drosophila melanogaster Invertebrates GLUT GLUT ncbigene_synonym Glut3 42036
Drosophila melanogaster Invertebrates PFK PFK ncbigene_symbol Pfk 36060
Drosophila melanogaster Invertebrates PFK PFK ncbigene_synonym CG15812 38379
Drosophila melanogaster Invertebrates G6PD G6PD ncbigene_synonym Zw 32974
Drosophila melanogaster Invertebrates GFAT GFAT ncbigene_synonym Gfat1 3354921
Drosophila melanogaster Invertebrates CTP CTP ncbigene_symbol ctp 31405
Drosophila melanogaster Invertebrates COA COA ncbigene_symbol Coa 248135
Drosophila melanogaster Invertebrates OGT OGT ncbigene_synonym sxc 35486

Chemical mentions

Word Match MeSH Name ChEBI
ManNAc-6-P NA mesh:C430285
Glucose Glucose mesh:D005947 D-glucopyranose chebi:4167
Pentose phosphate Pentoses mesh:D010429 pentose chebi:25901
Pyruvate NA mesh:D011773
UDP Uridine Diphosphate mesh:D014530 UDP chebi:17659
UTP Uridine Triphosphate mesh:D014544 UTP chebi:15713

Disease mentions

Word Match MeSH Name DOID