Upper panel

Upper panel. In normal cells, alternative NHEJ pathway (Alt NHEJ) is a minor DSB repair pathway compared with DNA-PK-dependent NHEJ (Classic NHEJ). Lower panel. In cancer cells, the steady state levels of key DNA-PK-dependent NHEJ proteins are reduced whereas the steady state levels of key alternative NHEJ are increased. This results in increased activity of the Alt NHEJ pathway and reduced activity of the DNA-PK-dependent NHEJ (CNHEJ) pathway.
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Publication

Targeting abnormal DNA double strand break repair in cancer. () Feyruz V. Rassool, et al. Cell Mol Life Sci. ;67(21):3699-3710. Figure: F3.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates DSB DSB ncbigene_symbol dsb 38252
Drosophila melanogaster Invertebrates Alt ALT ncbigene_symbol alt 42127
Drosophila melanogaster Invertebrates Alt ALT ncbigene_synonym CG1640 32292
Drosophila melanogaster Invertebrates Alt A1T ncbigene_synonym Ca-alpha1T 31550
Drosophila melanogaster Invertebrates Alt A1T ncbigene_synonym alphaTub84B 40848
Drosophila melanogaster Invertebrates Art ART ncbigene_symbol art 250198
Drosophila melanogaster Invertebrates Art ART ncbigene_synonym Dll 37973
Drosophila melanogaster Invertebrates MRN MRN ncbigene_symbol mrn 39688
Drosophila melanogaster Invertebrates Ku70 KU70 ncbigene_synonym Blm 41366
Drosophila melanogaster Invertebrates Ku70 KU70 ncbigene_synonym Irbp 117419
Drosophila melanogaster Invertebrates PKcs PKC ncbigene_synonym inaC 36897
Drosophila melanogaster Invertebrates PKcs PKC ncbigene_synonym Pkc98E 43428
Drosophila melanogaster Invertebrates PKcs PKC ncbigene_synonym aPKC 47594
Drosophila melanogaster Invertebrates PKcs PKC ncbigene_synonym Pkc53E 48311
Drosophila melanogaster Invertebrates PARP PARP ncbigene_symbol Parp 3355109
Drosophila melanogaster Invertebrates Ligl LIG1 ncbigene_synonym DNAlig1 37791
Drosophila melanogaster Invertebrates XRCC1 XRCC1 ncbigene_symbol XRCC1 31451
Drosophila melanogaster Invertebrates XRCC4 XRCC4 ncbigene_synonym CG12728 31526
Drosophila melanogaster Invertebrates LigaseIV LIGASEIV ncbigene_synonym DNAlig4 32322
Homo sapiens Primates Alt ALT ncbigene_synonym GPT 2875
Homo sapiens Primates Alt AIT ncbigene_synonym SLC5A8 160728
Homo sapiens Primates Art ART ncbigene_synonym AGRP 181
Homo sapiens Primates Art ART ncbigene_synonym ARTN 9048
Homo sapiens Primates MRN MRN famplex_relations MRE11 4361
Homo sapiens Primates MRN MRN famplex_relations NBN 4683
Homo sapiens Primates MRN MRN famplex_relations RAD50 10111
Homo sapiens Primates MRN MRN famplex_relations WDCP 80304
Homo sapiens Primates Ku70 KU70 ncbigene_synonym XRCC6 2547
Homo sapiens Primates Ku86 KU86 ncbigene_synonym XRCC5 7520
Homo sapiens Primates PKcs PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKcs PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKcs PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKcs PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKcs PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKcs PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKcs PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKcs PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKcs PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKcs PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKcs PKC famplex_relations PRKD3 23683
Homo sapiens Primates PARP PARP ncbigene_synonym PARP1 142
Homo sapiens Primates PARP PARP ncbigene_synonym COL11A2 1302
Homo sapiens Primates PARP PARP famplex_relations PARP2 10038
Homo sapiens Primates PARP PARP famplex_relations PARP3 10039
Homo sapiens Primates PARP PARP famplex_relations PARP4 143
Homo sapiens Primates PARP PARP famplex_relations PARP6 56965
Homo sapiens Primates PARP PARP famplex_relations PARP8 79668
Homo sapiens Primates PARP PARP famplex_relations PARP9 83666
Homo sapiens Primates PARP PARP famplex_relations PARP10 84875
Homo sapiens Primates PARP PARP famplex_relations PARP11 57097
Homo sapiens Primates PARP PARP famplex_relations PARP12 64761
Homo sapiens Primates PARP PARP famplex_relations PARP14 54625
Homo sapiens Primates PARP PARP famplex_relations PARP15 165631
Homo sapiens Primates PARP PARP famplex_relations PARP16 54956
Homo sapiens Primates PARP PARP famplex_relations TNKS 8658
Homo sapiens Primates PARP PARP famplex_relations TNKS2 80351
Homo sapiens Primates PARP PARP famplex_relations TIPARP 25976
Homo sapiens Primates Ligl LIG1 ncbigene_symbol LIG1 3978
Homo sapiens Primates Ligl LIG1 ncbigene_synonym LRIG1 26018
Homo sapiens Primates XRCC1 XRCC1 ncbigene_symbol XRCC1 7515
Homo sapiens Primates (WRN WRN ncbigene_symbol WRN 7486
Homo sapiens Primates XRCC4 XRCC4 ncbigene_symbol XRCC4 7518
Homo sapiens Primates XLF XLF ncbigene_synonym NHEJ1 79840

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID