The molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling

Schematic representation of the molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling. Activation of the Ras/MAPK pathway stimulates mTORC1 activity through the coordinated action of the kinases ERK1/2 and RSK on the TSC protein complex upstream mTORC1, and on Raptor, an important partner of mTOR within mTORC1.
The molecular mechanisms employed by the Ras/MAPK pathway to regulate mTORC1 signaling
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Publication

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1). (2011) Audrey Carriere, et al. J Biol Chem. 2011 Jan 7;286(1):567-577. Figure: F8.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Drosophila melanogaster Invertebrates Ras RAS ncbigene_symbol ras 43873
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras64B 38494
Drosophila melanogaster Invertebrates Ras RAS ncbigene_synonym Ras85D 41140
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K21B 33203
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K59F 37733
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K68D 39329
Drosophila melanogaster Invertebrates PI3K PI3K ncbigene_synonym Pi3K92E 42446
Drosophila melanogaster Invertebrates Akt AKT ncbigene_symbol Akt 41957
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym MKP-4 32963
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym p38b 34780
Drosophila melanogaster Invertebrates MAPK MAPK ncbigene_synonym rl 3354888
Drosophila melanogaster Invertebrates TSC1 TSC1 ncbigene_symbol Tsc1 42862
Drosophila melanogaster Invertebrates Raf RAF ncbigene_symbol Raf 31221
Drosophila melanogaster Invertebrates TSC2 TSC2 ncbigene_synonym gig 40201
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Dsor1 31872
Drosophila melanogaster Invertebrates MEK MEK ncbigene_synonym Mtk 36708
Drosophila melanogaster Invertebrates Rheb RHEB ncbigene_symbol Rheb 117332
Drosophila melanogaster Invertebrates RSK RSK ncbigene_synonym S6kII 33139
Drosophila melanogaster Invertebrates ERK ERK ncbigene_synonym Erk7 31877
Drosophila melanogaster Invertebrates MNK MNK ncbigene_synonym lok 35288
Drosophila melanogaster Invertebrates MTORC1 MTORC1 ncbigene_synonym Crtc 39970
Drosophila melanogaster Invertebrates PRAS40 PRAS40 ncbigene_symbol PRAS40 26067067
Drosophila melanogaster Invertebrates Raptor RAPTOR ncbigene_symbol raptor 31543
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_symbol Mtor 36264
Drosophila melanogaster Invertebrates MTOR MTOR ncbigene_synonym Tor 47396
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4E7 31059
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4E4 38743
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4E5 38878
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4E3 38923
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4E6 43422
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4E1 45525
Drosophila melanogaster Invertebrates EIF4E) EIF4E ncbigene_synonym eIF4EHP 326255
Drosophila melanogaster Invertebrates 4E-BP1 4E-BP1 ncbigene_synonym Thor 33569
Drosophila melanogaster Invertebrates S6K S6K ncbigene_symbol S6k 38654
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT1 284
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT2 285
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations ANGPT4 51378
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations AREG 374
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations BDNF 627
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations CSF1 1435
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA1 1942
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA2 1943
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA3 1944
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA4 1945
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EFNA5 1946
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EGF 1950
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations EREG 2069
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF1 2246
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF10 2255
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF16 8823
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF17 8822
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF18 8817
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF19 9965
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF2 2247
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF20 26281
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF21 26291
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF22 27006
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF23 8074
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF3 2248
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF4 2249
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF5 2250
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF6 2251
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF7 2252
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF8 2253
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FGF9 2254
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations FLT3LG 2323
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations HGF 3082
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations IGF1 3479
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations IGF2 3481
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations INS 3630
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations KITLG 4254
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NGF 4803
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NTF3 4908
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations NTF4 4909
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFA 5154
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFB 5155
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFC 56034
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PDGFD 80310
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations PGF 5228
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations TGFA 7039
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFA 7422
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFB 7423
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFC 7424
Homo sapiens Primates GrowthFactors GROWTHFACTOR famplex_relations VEGFD 2277
Homo sapiens Primates Ras RAS famplex_relations KRAS 3845
Homo sapiens Primates Ras RAS famplex_relations HRAS 3265
Homo sapiens Primates Ras RAS famplex_relations NRAS 4893
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R1 5295
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R2 5296
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates MAPK MAPK famplex_relations MAPK1 5594
Homo sapiens Primates MAPK MAPK famplex_relations MAPK3 5595
Homo sapiens Primates MAPK MAPK famplex_relations MAPK11 5600
Homo sapiens Primates MAPK MAPK famplex_relations MAPK12 6300
Homo sapiens Primates MAPK MAPK famplex_relations MAPK13 5603
Homo sapiens Primates MAPK MAPK famplex_relations MAPK14 1432
Homo sapiens Primates MAPK MAPK famplex_relations MAPK8 5599
Homo sapiens Primates MAPK MAPK famplex_relations MAPK9 5601
Homo sapiens Primates MAPK MAPK famplex_relations MAPK10 5602
Homo sapiens Primates TSC1 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates Raf RAF ncbigene_synonym ZHX2 22882
Homo sapiens Primates Raf RAF famplex_relations ARAF 369
Homo sapiens Primates Raf RAF famplex_relations BRAF 673
Homo sapiens Primates Raf RAF famplex_relations RAF1 5894
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates MEK MEK ncbigene_synonym MAP2K7 5609
Homo sapiens Primates MEK MEK famplex_relations MAP2K1 5604
Homo sapiens Primates MEK MEK famplex_relations MAP2K2 5605
Homo sapiens Primates Rheb RHEB ncbigene_symbol RHEB 6009
Homo sapiens Primates Rheb RHEB ncbigene_synonym RHEBP1 6008
Homo sapiens Primates RSK RSK ncbigene_synonym RPS6KA1 6195
Homo sapiens Primates RSK RSK ncbigene_synonym RPS6KA2 6196
Homo sapiens Primates RSK RSK ncbigene_synonym RPS6KA3 6197
Homo sapiens Primates RSK RSK famplex_relations RPS6KA4 8986
Homo sapiens Primates RSK RSK famplex_relations RPS6KA5 9252
Homo sapiens Primates RSK RSK famplex_relations RPS6KA6 27330
Homo sapiens Primates RSK RSK famplex_relations RPS6KB1 6198
Homo sapiens Primates RSK RSK famplex_relations RPS6KB2 6199
Homo sapiens Primates ERK ERK ncbigene_synonym EPHB2 2048
Homo sapiens Primates MNK MNK ncbigene_synonym ATP7A 538
Homo sapiens Primates MTORC1 MTORC1 famplex_relations MTOR 2475
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates PRAS40 PRAS40 ncbigene_synonym AKT1S1 84335
Homo sapiens Primates EIF4E) EIF4E ncbigene_symbol EIF4E 1977
Homo sapiens Primates EIF4E) EIF4E famplex_relations EIF4E2 9470
Homo sapiens Primates EIF4E) EIF4E famplex_relations EIF4E3 317649
Homo sapiens Primates 4E-BP1 4E-BP1 ncbigene_synonym EIF4EBP1 1978

Chemical mentions

Word Match MeSH Name ChEBI

Disease mentions

Word Match MeSH Name DOID
Cancer NA
Cardiomyopathy NA
Lung cancer NA
Noonan syndrome NA