PI3 kinase signaling pathway in glioma

PI3 kinase signaling pathway in glioma. Class I PI3 kinases are activated by upstream signals from receptor tyrosine kinases (RTKs) including EGFR and other RTKs. PI3 kinase catalyzes production of the second messenger PIP3, which actives both Akt and PKC. Akt and PKC phosphorylate multiple downstream substrates. We found Akt was dispensable for mitogenic signaling between EGFR and mTOR in glioma cells, whereas PKC was critical (33). PIP3 is negatively regulated by the tumor suppressor PTEN, a phosphatase driving dephosphorylation of PIP3
PI3 kinase signaling pathway in glioma
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Publication

Targeting the RTK-PI3K-mTOR Axis in Malignant Glioma: Overcoming Resistance. () Qi-Wen Fan, et al. Curr Top Microbiol Immunol. ;347:279-296. Figure: F1.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates RTKS(EGFR,IGF-1R) IGF1R ncbigene_symbol IGF1R 3480
Homo sapiens Primates (EGFR, EGFR ncbigene_symbol EGFR 1956
Homo sapiens Primates p85 P85 ncbigene_synonym PIK3R1 5295
Homo sapiens Primates p85 P85 ncbigene_synonym PIK3R2 5296
Homo sapiens Primates p85 P85 ncbigene_synonym ARHGEF7 8874
Homo sapiens Primates p85 P85 ncbigene_synonym CBFA2T2 9139
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R13B 23368
Homo sapiens Primates p85 P85 ncbigene_synonym PPP1R12C 54776
Homo sapiens Primates P110 P110 ncbigene_synonym CUX1 1523
Homo sapiens Primates P110 P110 ncbigene_synonym SART3 9733
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CA 5290
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CB 5291
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CD 5293
Homo sapiens Primates PI3K PI3K ncbigene_synonym PIK3CG 5294
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R3 8503
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R4 30849
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R5 23533
Homo sapiens Primates PI3K PI3K famplex_relations PIK3R6 146850
Homo sapiens Primates PTEN PTEN ncbigene_symbol PTEN 5728
Homo sapiens Primates PDK1 PDK1 ncbigene_symbol PDK1 5163
Homo sapiens Primates PDK1 PDK1 ncbigene_synonym PDPK1 5170
Homo sapiens Primates PDK PDK famplex_relations PDK2 5164
Homo sapiens Primates PDK PDK famplex_relations PDK3 5165
Homo sapiens Primates PDK PDK famplex_relations PDK4 5166
Homo sapiens Primates Akt AKT ncbigene_synonym AKT1 207
Homo sapiens Primates Akt AKT famplex_relations AKT2 208
Homo sapiens Primates Akt AKT famplex_relations AKT3 10000
Homo sapiens Primates PKC PKC ncbigene_synonym PRRT2 112476
Homo sapiens Primates PKC PKC famplex_relations PRKCA 5578
Homo sapiens Primates PKC PKC famplex_relations PRKCB 5579
Homo sapiens Primates PKC PKC famplex_relations PRKCD 5580
Homo sapiens Primates PKC PKC famplex_relations PRKCE 5581
Homo sapiens Primates PKC PKC famplex_relations PRKCG 5582
Homo sapiens Primates PKC PKC famplex_relations PRKCH 5583
Homo sapiens Primates PKC PKC famplex_relations PRKCI 5584
Homo sapiens Primates PKC PKC famplex_relations PRKCQ 5588
Homo sapiens Primates PKC PKC famplex_relations PRKCZ 5590
Homo sapiens Primates PKC PKC famplex_relations PRKD3 23683
Homo sapiens Primates FKHR FKHR ncbigene_synonym FOXO1 2308
Homo sapiens Primates GSK3B GSK3B ncbigene_symbol GSK3B 2932
Homo sapiens Primates BAD BAD ncbigene_symbol BAD 572
Homo sapiens Primates TSC2 TSC2 ncbigene_symbol TSC2 7249
Homo sapiens Primates TSC1/TSC2 TSC1 ncbigene_symbol TSC1 7248
Homo sapiens Primates TSC1/TSC2 TSC1 ncbigene_synonym CCL26 10344
Homo sapiens Primates Fasl FASL ncbigene_synonym FASLG 356
Homo sapiens Primates Fasl FAS1 ncbigene_synonym FAS 355
Homo sapiens Primates Bcl-2 BCL-2 ncbigene_synonym BCL2 596
Homo sapiens Primates CyclinD1 CCND1 ncbigene_symbol CCND1 595
Homo sapiens Primates MTOR MTOR ncbigene_symbol MTOR 2475
Homo sapiens Primates MTORC1 MTORC1 famplex_relations RPTOR 57521
Homo sapiens Primates Rictor RICTOR ncbigene_symbol RICTOR 253260
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MAPKAP1 79109
Homo sapiens Primates MTORC2 MTORC2 famplex_relations MLST8 64223
Homo sapiens Primates S6K S6K ncbigene_synonym RPS6KB1 6198

Chemical mentions

Word Match MeSH Name ChEBI
Ser Serine mesh:D012694 L-serine chebi:17115

Disease mentions

Word Match MeSH Name DOID
Cancer NA