FAS generates an endogenous ligand for PPARA in liver

FAS generates an endogenous ligand for PPARα in liver. FAS, a homodimer, synthesizes palmitate, which is converted to a CoA species that is incorporated into diacylglycerol (DAG). CDP-choline is generated by the sequential actions of CK (choline kinase) and CCT (CTP:phosphocholine cytidylyltransferase), enzymes in the Kennedy pathway of phosphatidylcholine synthesis. DAG and CDP-choline are converted by the ER protein choline-ethanolamine phosphotransferase-1 (CEPT1) to 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine. This phosphatidylcholine species binds to PPARα, which forms a heterodimer with RXR to activate gene expression.
FAS generates an endogenous ligand for PPARA in liver
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Publication

Lipoexpediency: de novo lipogenesis as a metabolic signal transmitter. () Irfan J. Lodhi, et al. Trends Endocrinol Metab. ;22(1):1-8. Figure: F2.

Gene mentions


Organism Group Word Match Source NCBI Symbol NCBI ID
Homo sapiens Primates FAS FAS ncbigene_symbol FAS 355
Homo sapiens Primates FAS FAS ncbigene_synonym FASN 2194
Homo sapiens Primates CCT CCT ncbigene_symbol CCT 907
Homo sapiens Primates CCT CCT ncbigene_synonym FLVCR2 55640
Homo sapiens Primates CCT CCT famplex_relations CCT2 10576
Homo sapiens Primates CCT CCT famplex_relations CCT3 7203
Homo sapiens Primates CCT CCT famplex_relations CCT4 10575
Homo sapiens Primates CCT CCT famplex_relations CCT5 22948
Homo sapiens Primates CCT CCT famplex_relations CCT6A 908
Homo sapiens Primates CCT CCT famplex_relations CCT6B 10693
Homo sapiens Primates CCT CCT famplex_relations CCT7 10574
Homo sapiens Primates CCT CCT famplex_relations CCT8 10694
Homo sapiens Primates CCT CCT famplex_relations TCP1 6950
Homo sapiens Primates CEPT1 CEPT1 ncbigene_symbol CEPT1 10390
Homo sapiens Primates CDP- CDP ncbigene_synonym CUX1 1523
Homo sapiens Primates CDP- CDP ncbigene_synonym NPPA 4878
Homo sapiens Primates Opo OPO ncbigene_synonym OFCC1 266553
Homo sapiens Primates PPARA PPARA ncbigene_symbol PPARA 5465
Homo sapiens Primates RXR RXR famplex_relations RXRA 6256
Homo sapiens Primates RXR RXR famplex_relations RXRB 6257
Homo sapiens Primates RXR RXR famplex_relations RXRG 6258
Mus musculus Rodents FAS FAS ncbigene_symbol Fas 14102
Mus musculus Rodents FAS FAS ncbigene_synonym Fasn 14104
Mus musculus Rodents CoA COA ncbigene_synonym Hps3 12807
Mus musculus Rodents CCT CCT ncbigene_synonym Tcp1 21454
Mus musculus Rodents CCT CCT ncbigene_synonym Flvcr2 217721
Mus musculus Rodents CEPT1 CEPT1 ncbigene_symbol Cept1 99712
Mus musculus Rodents CDP- CDP ncbigene_synonym Cux1 13047
Mus musculus Rodents Opo OPO ncbigene_synonym Ofcc1 218165
Mus musculus Rodents PPARA PPARA ncbigene_symbol Ppara 19013
Rattus norvegicus Rodents FAS FAS ncbigene_symbol Fas 246097
Rattus norvegicus Rodents CEPT1 CEPT1 ncbigene_symbol Cept1 310773
Rattus norvegicus Rodents CDP- CDP ncbigene_synonym Cux1 116639
Rattus norvegicus Rodents PPARA PPARA ncbigene_symbol Ppara 25747
Capra hircus Mammals FAS FAS ncbigene_symbol FAS 102180451
Capra hircus Mammals FAS FAS ncbigene_synonym FASN 100861286
Capra hircus Mammals CEPT1 CEPT1 ncbigene_symbol CEPT1 102182086
Capra hircus Mammals PPARA PPARA ncbigene_symbol PPARA 100861393
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym Fas2 31364
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym FASN1 33524
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym Fas3 35097
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym fand 36514
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym tei 36521
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym rg 44531
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym FASN2 117361
Drosophila melanogaster Invertebrates FAS FAS ncbigene_synonym FASN3 3355111
Drosophila melanogaster Invertebrates CK CK ncbigene_symbol ck 34882
Drosophila melanogaster Invertebrates CoA COA ncbigene_symbol Coa 248135
Drosophila melanogaster Invertebrates CCT CCT ncbigene_synonym beat-Ia 34947
Drosophila melanogaster Invertebrates CCT CCT ncbigene_synonym Pcyt1 117353
Drosophila melanogaster Invertebrates Opo OPO ncbigene_synonym opm 32435

Chemical mentions

Word Match MeSH Name ChEBI
Choline Choline mesh:D002794 choline chebi:15354
CDP Cytidine Diphosphate mesh:D003565 CDP chebi:17239
Palmitoyl-CoA Palmitoyl Coenzyme A mesh:D010171 palmitoyl-CoA chebi:15525
3-phosphocholine Phosphorylcholine mesh:D010767 phosphocholine chebi:18132
Phosphocholine Phosphorylcholine mesh:D010767 phosphocholine chebi:18132

Disease mentions

Word Match MeSH Name DOID